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Enzyme-Triggered fluorescence turn-on： A Probe for Specifically Imaging Ovarian-Cancer-Related γ-Glutamyltranspeptidase

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Chinese Journal of Chemistry 2017年第11期35卷 1711-1716页

作者： Jie Tian Qinglong Yan Ying Zhu Jichao Zhang Jiao Li Ben Shi Ge Xu Chunhai Fan Chunchang Zhao Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science & Technology Shanghai 200237 China Division of Physical Biology & Bioimaging Center Shanghai Synchrotron Radiation Facility CAS Key Laborato- ry of lnterfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China

A fluorescent turn-on probe for specifically targeting γ-glutamyltranspeptidase （GGT） was designed and synthe- sized by integrating boron-dipyrromethene （BODIPY） as a chromophore and glutathione （GSH） as the GGT sub- strate. GGT-catalyzed the cleavage of the γ-glutamyl bond and generated the aromatic hydrocarbon transfer between the sulfur and the nitrogen atom in BODIPY, leading to distinct optical changes. Such specific responsiveness pro- vides an easily distinguishable fluorescence signal to visualize the GGT activity in living cells and differentiate GGT-positive cancer cells from GGT-negative cells.

关键词： fluorescence turn-on GGT the aromatic hydrocarbon transfer living cells specifically targeting

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Direct identification of HMX via guest-induced fluorescence turn-on of molecular cage

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Chinese Chemical Letters 2021年第12期32卷 4006-4010页

作者： Chen Wang Jin Shang Li Tian Hongwei Zhao Peng Wang Kai Feng Guokang He Jefferson Zhe Liu Wei Zhu Guangtao Li Department of Chemistry Tsinghua UniversityBeijing 100084China School of Energy and Environment City University of Hong KongHong KongChina Department of Mechanical Engineering The University of MelbourneParkvilleVIC 3010Australia School of Biology and Biological Engineering South China University of TechnologyGuangzhou 510006China Institute of chemistry Hebrew University of JerusalemJerusalem 91904Israel

Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX) is one of the most widely used powerful explosives. The direct and selective detection of HMX, without the requirement of specialized equipment, remains a great challenge due to its extremely low volatility, unfavorable reduction potential and lack of aromatic rings. Here, we report the first chemical probe of direct identification of HMX at ppb sensitivity based on a designed metal-organic cage(MOC). The cage features two unsaturated dicopper units and four electron donating amino groups inside the cavity, providing multiple binding sites to selectively enhance host-guest events. It was found that compared to other explosive molecules the capture of HMX inside the cavity would strongly modulate the emissive behavior of the host cage, resulting in highly induced fluorescence “turn-on”(160 folds). Based on the density functional theory(DFT) simulation, the mutual fit of both size and binding sites between host and guest leads to the synergistic effects that perturb the ligand-to-metal charge-transfer(LMCT) process, which is probably the origin of such selective HMX-induced turn-on behavior.

关键词： Chemical sensing Explosive detection HMX Molecular cage Host-guest chemistry fluorescence turn-on

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