检索结果-南通市图书馆

ferulic acid mediates prebiotic responses of cereal-derived arabinoxylans on host health

Animal Nutrition 2022年第2期9卷 31-38页

作者： Zeyu Zhang Pan Yang Jinbiao Zhao State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Dietary fiber is named as “the 7th nutrient” for humans, which is beneficial to improve intestinal healthand prevent metabolic disease of the host. Mechanisms of dietary fiber administration on improved hosthealth are mediated by short chain fatty acids (SCFA), which are reported to activate G protein-coupledreceptors (GPR) and suppress activity of histone deacetylase (HDAC) to down-regulate expression ofnuclear factor-к-gene binding (NF-кB) signaling. Arabinoxylan is fermented by gut microbiota to produceSCFA and improved microbial community composition, intestinal barrier functions and host health.Interestingly, the latest publications have observed that ferulic acid combined with the arabinose inarabinoxylans from various cereal grains can be released through gut microbial fermentation. ferulic acidcan improve antioxidase activity and decrease reactive oxygen species (ROS) concentration by activatingthe signaling pathway of Kelch-like ECH-associated protein-1 and nuclear factor E2-related factor-2(Keap1-Nrf2). However, the role of ferulic acid in cooperation with SCFA produced from microbialfermentation of cereal-derived arabinoxylan to regulate the intestinal health and host metabolisms, hasbeen widely unclear. This review summarizes the potential mechanisms of ferulic acid from microbialfermentation of cereal-derived arabinoxylans on immunological functions and physiological metabolismsof the host. The evidence presented in the review indicates that dietary supplementation withcereal-derived arabinoxylans improves antioxidant capacity of intestinal epithelial cells due to theproduction of ferulic acid and SCFA from microbial fermentation. ferulic acid can cooperate with SCFA toregulate intestinal integrity and immunological functions of the host. Peroxisome proliferator activatedreceptorg (PPARg) may play an important role in integrating ferulic acid and SCFA to regulate host healthand metabolism.

关键词： Arabinoxylan Short-chain fatty acid ferulic acid Gut health Energy metabolism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dietary ferulic acid and vanillic acid on inflammation,gut barrier function and growth performance in lipopolysaccharide-challenged piglets

引用

Animal Nutrition 2022年第1期8卷 144-152页

作者： Ruizhi Hu Shusong Wu Baizhen Li Jijun Tan Jiahao Yan Ying Wang Zhiyi Tang Ming Liu Chenxing Fu Hongfu Zhang Jianhua He Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients College of Animal Science and TechnologyHunan Agricultural UniversityChangsha410128China Beijing China-Agri HongKe Bio-Technology Co. Ltd.Beijing102206China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing100193China

ferulic acid(FA)and vanillic acid(VA)are considered as major phenolic metabolites of cyanidin 3-glucoside,a polyphenol that widely exists in plants that possess a protective effect against oxidative stress and inflammation in our previous study.This study aimed to investigate the effect of FA and VA on inflammation,gut barrier function,and growth performance in a weaned piglet model challenged with lipopolysaccharide(LPS).Thirty-six piglets(PIC 337×C48,28 d of age)were randomly allocated into 3 treatments with 6 replicate pens(2 piglets per pen).They were fed with a basal diet or a diet containing 4,000 mg/kg of FA or VA.Dietary supplementation of VA significantly increased average daily gain(ADG)(Pacid reactive substances(TBARS),interlukin(IL)-1β,IL-2,IL-6,and tumor necrosis factor(TNF)-α(P<0.05),and enhanced the expression of tight junction protein oclaudin(P<0.05).Analysis of gut microbiota indicated that both FA and VA increased the Firmicutes/Bacteroidetes ratio alongside reducing the relative abundance of the Prevotellaceae family including Prevotella 9 and Prevotella 2 genera,but enriched the Lachoiraceaea family including the Lachnospiraceae FCS020 group(P<0.05).Moreover,VA reduced the relative abundance of Prevotella 7 and Prevotella 1 but enriched Lachnospira,Eubacterium eligens group,and Eubacterium xylanophilum group(P<0.05),while FA showed a limited effect on these genera.The results demonstrated that both VA and FA could alleviate inflammation and oxidative stress,but only VA has a significant positive effect on the growth performance of LPS-challenged piglets potentially through modulating gut microbiota.

关键词： ferulic acid Vanillic acid Inflammation Gut barrier function Growth performance Piglet

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The release and catabolism of ferulic acid in plant cell wall by rumen microbes:A review

引用

Animal Nutrition 2022年第2期9卷 335-344页

作者： Yan-Lu Wang Wei-Kang Wang Qi-Chao Wu Hong-Jian Yang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

ferulic acid(FA)is one of the most abundant hydroxycinnamic acids in the plant world,especially in the cell wall of grain bran,in comparison with forage and crop residues.Previous studies noted that FA was mainly linked with arabinoxylans and lignin in plant cell walls in ester and ether covalent forms.After forages were ingested by ruminant animals or encountered rumen microbial fermentation in vitro,these cross-linkages form physical and chemical barriers to protect cell-wall carbohydrates from microbial attack and enzymatic hydrolysis.Additionally,increasing studies noted that FA presented some toxic effect on microbial growth in the rumen.In recent decades,many studies have addressed the relationships of ester and/or ether-linked FA with rumen nutrient digestibility,and there is still some controversy whether these linkages could be used as a predicator of forage digestibility in ruminants.The authors in this review summarized the possible relationships between ester and/or ether-linked FA and fiber digestion in ruminants.Rumen microbes,especially bacteria and fungi,were found capable of breaking down the ester linkages within plant cell walls by secreting feruloyl and p-coumaroyl esterase,resulting in the release of free FA and improvement of cell wall digestibility.The increasing evidence noted that these esterases secreted by rumen microbes presented synergistic effects with xylanase and cellulase to effectively hydrolyze forage cell walls.Some released FA were absorbed through the rumen wall directly and entered into blood circulation and presented antioxidant effects on host animals.The others were partially catabolized into volatile fatty acids by rumen microbes,and the possible catabolic pathways discussed.To better understand plant cell wall degradation in the rumen,the metabolic fate of FA along with lignin decomposition mechanisms are needed to be explored via future microbial isolation and incubation studies with aims to maximize dietary fiber intake and enhance fiber digestion in ruminant animals.

关键词： Rumen microbes ferulic acid Fiber digestion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid

引用

Journal of Pharmaceutical Analysis 2023年第12期13卷 1496-1509页

作者： Yanhua Liu Xin Zhang Shu Yang Zhi Zhou Lu Tian Wanfang Li Jinfeng Wei Zeper Abliz Zhonghua Wang Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China) National Ethnic Affairs CommissionBeijing100081China Center for Imaging and Systems Biology College of Life and Environmental SciencesMinzu University of ChinaBeijing100081China New Drug Safety Evaluation Center Institute of Materia MedicaPeking Union Medical CollegeBeijing100050China Key Laboratory of Ethnomedicine of Ministry of Education School of PharmacyMinzu University of ChinaBeijing100081China

Diabetic cardiomyopathy(DCM)is a metabolic disease and a leading cause of heart failure among people with diabetes.Mass spectrometry imaging(MSI)is a versatile technique capable of combining the molecular specificity of mass spectrometry(MS)with the spatial information of imaging.In this study,we used MSI to visualize metabolites in the rat heart with high spatial resolution and sensitivity.We optimized the air flow-assisted desorption electrospray ionization(AFADESI)-MSI platform to detect a wide range of metabolites,and then used matrix-assisted laser desorption ionization(MALDI)-MSI for increasing metabolic coverage and improving localization resolution.AFADESI-MSI detected 214 and 149 metabolites in positive and negative analyses of rat heart sections,respectively,while MALDI-MSI detected 61 metabolites in negative analysis.Our study revealed the heterogenous metabolic profile of the heart in a DCM model,with over 105 region-specific changes in the levels of a wide range of metabolite classes,including carbohydrates,amino acids,nucleotides,and their derivatives,fatty acids,glycerol phospholipids,carnitines,and metal ions.The repeated oral administration of ferulic acid during 20 weeks significantly improved most of the metabolic disorders in the DCM model.Our findings provide novel insights into the molecular mechanisms underlying DCM and the potential of ferulic acid as a therapeutic agent for treating this condition.

关键词： Mass spectrometry imaging Diabetic cardiomyopathy Metabolic reprogramming ferulic acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protective effects of ferulic acid against ionizing radiation-induced oxidative damage in rat lens through activating Nrf2 signal pathway

引用

International Journal of Ophthalmology(English edition) 2023年第5期16卷 687-693页

作者： Yueqin Chen Jiawei Shen Xiaoran Zhang Weiping Gao Qian Cao Feng Yan Chunyan Xue Department of Ophthalmology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Nanjing University of Chinese Medicine Nanjing 210029Jiangsu ProvinceChina Department of Ophthalmology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002Jiangsu ProvinceChina

AIM: To examine the protection of ferulic acid(FA) against ionizing radiation(IR)-induced lens injury in rats, as well as the underlying mechanisms.METHODS: FA(50 mg/kg) was administered to rats for 4 consecutive days before they were given 10 Gy γ-radiation, as well as for 3 consecutive days afterward. Two weeks after radiation, the eye tissues were collected. Histological alterations were evaluated by hematoxylineosin staining. Enzyme linked immunosorbent assay(ELISA) was utilized to assess the activities of glutathione reductase(GR) and superoxide dismutase(SOD), as well as the levels of glutathione(GSH) and malondialdehyde(MDA) in the lenses. The protein and m RNA levels of Bcl-2, caspase-3, Bax, heme oxygenase-1(HO-1), and glutamatecysteine ligase catalytic subunit(GCLC) were quantified using Western blot and quantitative reverse transcription polymerase chain reaction, respectively. With nuclear extracts, the nuclear factor erythroid-2 related factor(Nrf2) protein expressions in the nuclei were also measured.RESULTS: Rats exposed to IR showed lens histological alterations which could be alleviated by FA. FA treatment reversed apoptosis-related markers in IR-induced lens, as evidenced by lower levels of Bax and caspase-3 and higher level of Bcl-2. Furthermore, IR induced oxidative damage manifested by decreased GSH level, increased MDA level, and decreased SOD and GR activities. FA boosted nuclear translocation of Nrf2 and increased the expressions of HO-1 and GCLC to inhibit oxidative stress, as evidenced by an increase in GSH, a decrease in MDA, and an increase in GR and SOD activities.CONCLUSION: FA may work well in preventing and treating IR-induced cataract through promoting the Nrf2 signal pathway to attenuate oxidative damage and cell apoptosis.

关键词： ferulic acid ionizing radiation lens oxidative stress Nrf2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantitative Extraction of p-Coumaric acid and ferulic acid in Different Gramineous Materials and Structural Changes of Residual Alkali Lignin

引用

Journal of Renewable Materials 2023年第2期11卷 555-566页

作者： Tanhao Zhang Shuo Zhang Wu Lan Fengxia Yue State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510640China

ferulic acid(FA)and p-coumaric acid(pCA)in bagasse,wheat straw,corn straw,and corncob were extracted by alkaline hydrolysis and characterized by gas chromatography(GC)and gas chromatography-mass spectrometry(GC-MS).It was found that the FA and most of the pCA in gramineous biomass could be dissociated and released after being treated with 1 M NaOH at 100℃for 4 h.The yields of pCA/FA in bagasse,wheat straw,corn straw,and corncob determined by GC-FID are 39.8/11.5,13.7/11.0,28.0/11.0,and 35.1/14.5 mg/g,respectively.The raw materials and the treated solid residues were characterized by gel-state 2D Heteronuclear Single Quantum Coherence Nuclear Magnetic Resonance(2D HSQC NMR).It was found that only a small amount of lignin was detected in the residue after alkali treatment,indicating that the alkali treatment conditions can effectively cleave the FA and pCA.Additionally,the lignin in the alkali solution was recovered and characterized by 2D HSQC NMR.The FA was not able to be detected by NMR,whereas a small amount of pCA remained in the alkali lignin.This study reveals the structural change of residual lignins during the quantitative isolation of FA and pCA,which is essential for the selective isolation of pCA/FA and valorization of residual alkali lignin.

关键词： Gramineae ferulic acid p-coumaric acid alkali lignin alkaline pretreatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of ferulic acid on Regulating the Neurovascular Unit:Implications for Ischemic Stroke Treatment

引用

World Journal of Traditional Chinese Medicine 2022年第2期8卷 210-217页

作者： Xiang Wang Xin-Ran Liu Ke-Xin Li Xiang Fan Yang Liu Graduate School Tianjin University of Traditional Chinese MedicineTianjinChina School of Chinese Materia Medic Tianjin University of Traditional Chinese MedicineTianjinChina Zhejiang Chinese Medical University ZhejiangChina Chinese Medical College Tianjin University of Traditional Chinese MedicineTianjinChina

ferulic acid(FA)is a phenolic phytochemical with antioxidant and anti-inflammatory pharmacological effects.In recent years,the neuroprotective effects of FA have been studied extensively.Many researchers have attempted to use FA to prevent and treat neurological diseases and have made some progress.This paper mainly collated the study of the protective effect of FA on stroke and summarized the protective effect of FA on ischemic stroke and the potential protective effects of FA on neurovascular units.

关键词： ferulic acid ischemic stroke neuroprotective effects neurovascular unit

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of a new ferulic acid certified reference material for use in clinical chemistry and pharmaceutical analysis

引用

Acta Pharmaceutica Sinica B 2015年第3期5卷 231-237页

作者： Dezhi Yang Fengfeng Wang Li Zhang Ningbo Gong Yang Lv Beijing Key Laboratory of Polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

This study compares the results of three certified methods,namely differential scanning calorimetry(DSC),the mass balance(MB) method and coulometric titrimetry(CT),in the purity assessment of ferulic acid certified reference material(CRM).Purity and expanded uncertainty as determined by the three methods were respectively 99.81%,0.16%;99.79%,0.16%;and 99.81%,0.26%with,in all cases,a coverage factor(k) of 2(P ? 95%).The purity results are consistent indicating that the combination of DSC,the MB method and CT provides a confident assessment of the purity of suitable CRMs like ferulic acid.

关键词： Differential scanning calorimetry Mass balance Coulometric titrimetry Certified reference material Uncertainty ferulic acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ferulic acid alleviates lipopolysaccharide-induced depression-like behavior by inhibiting inflammation and apoptosis

引用

Asian Pacific Journal of Tropical Biomedicine 2020年第12期10卷 523-531页

作者： Xiu-Mei Bo Ruo-Bing Yu Sai-Jun Du Rong-Li Zhang Ling He Medical Biological Experiment Credit Center Basic Medical CollegeXuzhou Medical UniversityXuzhou 221004China The First Clinical Medical College Xuzhou Medical UniversityXuzhou 221004China College of Life Sciences Xuzhou Medical UniversityXuzhou 221004China Department of Chemistry Xuzhou Medical UniversityXuzhou 221004China

Objective:To identify the anti-depressive effect of ferulic acid(FA)in mice exposed to lipopolysaccharide(LPS)and explore its molecular mechanisms.Methods:The mice were divided into 5 groups as follows:Control,LPS,LPS+SP,LPS+FA,and LPS+FA+anisomycin.The LPS+FA and LPS+FA+anisomycin groups were administered with FA(100 mg/kg,i.p.)once daily continuously for 7 days,and the other groups received an equivalent volume of saline.On the 7 th day,LPS(0.1 mg/m L,i.p.)was injected in all mice except the control group 30 min after FA or saline administration.The LPS+SP and LPS+FA+anisomycin groups were intravenously administered with SP600125[c-Jun N-terminal kinase(JNK)inhibitor](100μL/site,i.v.)and anisomycin(JNK activator)(100μL/site,i.v.)15 min before LPS,respectively.The depressive behaviors were assessed by open field test,sucrose preference test,and forced swimming test at 24 h post-LPS administration.Tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)levels in plasma were measured by ELISA.The levels of phospho-JNK,TNF-α,IL-1β,Bcl-2,Bax,cytochrome c and caspase-3 were evaluated by Western blotting.Results:FA alleviated depression symptoms caused by LPS in mice,including increasing sucrose water consumption in sucrose preference test and reducing the immobility time in forced swimming test.FA could inhibit upregulated levels of phospho-JNK,TNF-α,and IL-1β.FA also markedly decreased Bax,caspase-3,and cytochrome c,and increased Bcl-2 levels.Besides,SP600125 showed neuroprotective effect similar to FA which was attenuated by anisomycin.Conclusions:FA attenuates inflammation and apoptosis by inhibiting LPS-induced activation of JNK to alleviate depressionlike behaviors.

关键词： ferulic acid Lipopolysaccharide Depression JNK Inflammation Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design and synthesis of the ring-opened derivative of 3-n-butylphthalide-ferulic acid-glucose trihybrids as potential anti-ischemic agents

引用

Chinese Chemical Letters 2020年第7期31卷 1881-1886页

作者： Jianbing Wu Wei Yin Yinqiu Zhang Hui Ye Yunman Li Jide Tian Zhangjian Huang Yihua Zhang State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Drug DiscoveryChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines Department of PhysiologyChina Pharmaceutical UniversityNanjing 210009China Department of Molecular and Medical Pharmacology University of CaliforniaLos AngelesCA 90095United States

To improve aqueous solubility and anti-ischemic activity of 3-n-butylphthalide(NBP),we designed and synthesized the ring-opened derivative of NBP-ferulic acid-glucose trihybrids(S1-S8).These hybrids inhibited adenosine diphosphate(ADP)-or arachidonic acid(AA)-induced platelet aggregation,among them,S2 was 30-fold more water-soluble,and over 10-fold more potent in inhibition of platelet aggregation,as well as reduced ROS generation and protected primary neuronal cells from OGD/Rinduced damage,in comparison with NB P.Additionally,S2 was more active than its three moieties alone or in combination,suggesting that the activity of S2 may be attributed to the synergistic effects of these moieties.Importantly,in vivo studies indicated that S2 not only possessed good pharmacokinetic profile,but also improved NBP distribution in rodent brain,suggesting that the glucose moiety in S2 may be recognized by glucose transporter 1(GLUT1)on blood-brain barrier(BBB),promoting it to penetrate through BBB.Our findings suggest that S2 may be a promising candidate for the intervention of ischemic stroke,warranting further study.

关键词： 3-n-Butylphthalide ferulic acid Glucose Hybrids Ischemic Brain-blood barrier

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：