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Pharmacological methods for ovarian function and fertility preservation in women with cancer:A literature review

Oncology Research 2024年第8期32卷 1309-1322页

作者： ANA S.CVETANOVIC MATTEO LAMBERTINI KEVIN PUNIE GORANA G.MATOVINA BRKO NIKOLA D.ZIVKOVIC MAJA J.POPOVIC MARIJANA M.MILOVIC KOVACEVIC LAZAR S.POPOVIC Department for Oncology Medical Faculty NisUniversity of NisNis18000Serbia Clinic of Oncology University Clinical Centre NisNis18000Serbia Department of Internal Medicine and Medical Sciences(DiMI) School of MedicineUniversity of GenovaGenova16100Italy Department of Medical Oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenova16100Italy Department of General Medical Oncology and Multidisciplinary Breast Centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuven3001Belgium Department of Medical Oncology Oncology Institute of VojvodinaSremska Kamenica21208Serbia Department for Pathology Medical Faculty NisUniversity of NisNis18000Serbia Center for Pathology University Clinical Centre NisNis18000Serbia Faculty of Medicine University of Novi SadNovi Sad21000Serbia Department of Medical Oncology Institute of Oncology and Radiology SerbiaBelgrade11000Serbia

Oncofertility is an extremely signiﬁcant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but signiﬁcantly contributes to preserving life *** effect of chemotherapy can range from minimal effects to complete ovarian *** data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and *** ovarian suppression by administering a gonadotropin-releasing hormone agonist(GnRHa)during chemotherapy decreases the gonadotoxic effect of chemotherapy,thereby diminishing the chance of developing premature ovarian insufﬁciency(POI).At present,the concomitant administration of GnRH analogs during chemotherapy is the only accepted pharmacological method for preserving ovarian ***,most randomized studies on the effectiveness of luteinizing hormone-releasing hormone agonists during chemotherapy in preventing POI have been conducted in women with breast cancer,with a considerably small number of studies on patients with hematological ***,most randomized controlled trials on breast cancer have revealed a decrease in treatment-induced POI risk,regardless of the hormone receptor *** addition,studies on hematological malignancies have yielded negative results;nevertheless,theﬁndings must be interpreted with caution owing to numerous *** guidelines from the American Society of Clinical Oncology and ESMO Clinical Practice Guidelines recommend sperm,oocyte,and embryo cryopreservation as a standard practice and only offering GnRHa to patients when proven fertility preservation methods are not *** this manuscript,we present a comprehensive literature overview on the application of ovarian suppression with GnRHa during chemotherapy in patients with cancer by addressing preclinical and clinical data,as well as future perspectives in thisﬁeld

关键词： Gonadotropin-releasing hormone agonists(GnRHa) fertility preservation Premature ovarian insufficiency(POI) Premenopausal patients

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Update Knowledge Assessment and Influencing Predictor of Female fertility preservation in Oncologists

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Current Medical Science 2022年第4期42卷 824-831页

作者： Li-xia ZHU Lei JIN Jing-hang JIANG Liu YANG Zi-shui FANG Meng WANG Ying XIAO Qing-song XI Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Reproductive Medicine Center Jingmen Second People's HospitalJingmen 448000China Cancer Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:This study aims to offer an update assessment of the knowledge of Chinese oncologists on female fertility preservation,and identify the determinants that influence the implementation of fertility ***:A total of 713 Chinese oncologists with different specialties completed the online self-report questionnaire to assess their understanding of fertility risks in cancer treatment,knowledge on female fertility preservation,and perceptions on the barriers in referring patients for fertility ***:Although most oncologists were familiar with fertility risk in cancer treatment,half of them lacked the knowledge for reproduction and preservation *** the multivariable model,oncologists in a hospital with a specialized reproductive institution,positive precaution for fertility risk,and fertility preservation discussion with patients were significantly correlated with the possibility of fertility preservation ***:The intervention targets based on the update evaluation and identified influencing determinants will be helpful for all the oncofertility researchers,oncologists and institutions in future efforts for well-established female fertility preservation services.

关键词： fertility preservation oncologists female infertility neoplasms

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Stem cell-based therapies for fertility preservation in males:Current status and future prospects

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World Journal of Stem Cells 2020年第10期12卷 1097-1112页

作者： Han-Chao Liu Yun Xie Chun-Hua Deng Gui-Hua Liu Department of Andrology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Reproductive Medicine Research Center The Sixth Affiliated Hospital of Sun Yatsen UniversityGuangzhou 510655Guangdong ProvinceChina

With the decline in male fertility in recent years,strategies for male fertility preservation have received increasing *** this study,by reviewing current treatments and recent publications,we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation,focusing on the use of spermatogonial stem cells(SSCs),SSC niches,SSC-based testicular organoids,other stem cell types such as mesenchymal stem cells,and stem cell-derived extracellular *** conclusion,a more comprehensive understanding of the germ cell microenvironment,stem cell-derived extracellular vesicles,and testicular organoids will play an important role in achieving male fertility preservation.

关键词： fertility preservation Sperm cryopreservation Spermatogonial stem cell Testicular organoids Stem cell Extracellular vesicles

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fertility preservation in Cancer Patients

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Reproductive and Developmental Medicine 2021年第1期5卷 44-54页

作者： Yuan-Xue Jing Li-Li Zhang Hong-Xing Li Feng Yue Nai Hui Wang Shi-Long Xue Yi-Qing Wang Xue-Hong Zhang Reproductive Medicine Center The First Hospital of Lanzhou UniversityLanzhou 730000China Key Laboratory for Reproductive Medicine and Embryo of Gansu Lanzhou 730000China

Traditional radiotherapy and chemotherapy often cause irreversible damage to the fertility and endocrine function of cancer *** current methods of fertility preservation include freezing the sperms of adult and adolescent males after puberty;freezing the embryos,oocytes,and ovarian tissue of females;and drug intervention and fertility preservation *** article reviews fertility preservation in cancer patients with respect to current methods,indications,and some more recently developed methods that remain under investigation.

关键词： Cryopreservation of Ovarian Tissue Cryopreservation of Testis Tissue Cryopreserved Embryos and Oocytes fertility preservation In vitro Maturation

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Successful pregnancy in a seminoma patient after fertility preservation

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The Chinese-German Journal of Clinical Oncology 2012年第10期11卷 615-617页

作者： Qjngsong Xi Lixia Zhu Juan Hu Li Wu Xinling Ren Jihui Ai Department of Oncology Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Reproductive Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

The frequency of invasive cancer in young patients is increasing worldwide. For patients about to undergo a surgical procedure or to receive chemical therapy, radiation therapy, loss or impairment of fertility is a major issue. So the need for fertility protection and preservation became more intensity. Sperm banking is a standard accepted procedure for males to circumvent loss or damage to spermatozoa. Here we present a successful pregnancy in a testicular germ cell tumor patient following fertility preservation.

关键词： cryopreservation fertility preservation pregnancy seminoma

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fertility preservation for female patients with childhood and adolescent cancer

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Gynecology and Obstetrics Clinical Medicine 2022年第4期2卷 161-163页

作者： Yanru Hou Li Tian Huai L.Feng Reproductive Medicine Center Department of Obstetrics and GynecologyPeking University People's HospitalPeking University Health Science CenterBeijingChina New York fertility Center New York-Prebyterian Healthcare System Affiliate Weill Cornell Medical CollegeNew YorkUSA

With the significant cancer treatment in the past decades,>85%of children with cancer now survives into adulthood,and fertility preservation has become an important quality-of-life technology for them.1 Cancer treatment may include surgery,chemotherapy,radiotherapy,and/or hematopoietic stem cell transplantation(HSCT).2 Except for non-pelvic surgery,these treatments may affect ovarian function and consequently cause varying degrees of gonadal toxicity.3 Patients cured by anti-cancer treatment have a very high risk of premature ovarian insufficiency(POI).

关键词： fertility preservation Oocyte cryopreservation Ovary cryopreservation Childhood cancer Adolescent cancer

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Conservative laparoscopic surgery of adnex torsion for fertility preservation

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Laparoscopic, Endoscopic and Robotic Surgery 2018年第3期1卷 62-65页

作者： Wei Wei Lingxiu Huang Baijia Li Shaohan Zou Guanghui Song Department of Gynecology and Obstetrics Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Hangzhou Zha Nong Kou Community Health Service Center Hangzhou 310014China

Objectives:To evaluate the safety and efficacy of conservative laparoscopic surgery for adnexal torsion and the feasibility of secondary ***:This is a retrospective study that consists of 17 patients with clinically diagnosed adnexal torsion who have a desire for pregnancy in the *** performed conservative laparoscopic adnexal detorsion operations from January 2014 to June 2016 in Sir Run Run Shaw *** collected data,including age,onset time,maximum diameter of adnexal lesion,local blood flow signal,torsion degree,and recovery of local blood supply after detorsions,were *** blood flow of the lesion side,the antral follicles development,the basal endocrine hormone levels and the menstrual cycle were examined one-month and three-month post *** fertility was investigated ***:All cases had no obvious clinical postoperative *** were no significant changes on menstrual cycle and ovarian function during the follow-up ***:Adnexal torsion in young patients should be carefully treated and fertility reservation should be thoroughly *** decision to remove adnexa needs careful *** laparoscopic surgery is safe and does not increase the occurrence of serious *** is a higher possibility of a long delay between surgery and onset necrosis,but this is not always the *** if there is adnex thromboembolic infarction it does not result in serious complications such as pulmonary *** laparoscopic surgery can be performed first unless the clinician is certain it is already *** should do our best to reserve patients’fertility as much as *** necessary,a secondary surgery can be performed.

关键词： Adnexal torsion Laparoscopic conservative surgery fertility preservation

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Reproductive advance of fertility preservation in patients with early endometrial carcinoma or endometrial atypical hyperplasia

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Gynecology and Obstetrics Clinical Medicine 2022年第4期2卷 186-190页

作者： Jiao Yu Yangyang Zhang Huixia Yang Yang Xu Department of Obstetrics and Gynecology Peking University First HospitalBeijing100034China

Endometrial cancer(EC)is the fourth common cancer in women worldwide with its incidence rising each year.10%–15%young patients are diagnosed of *** patients of childbearing age with early endometrial cancer or atypical hyperplasia,it is necessary to consider surgical removal of uterus after they have given *** is a big challenge for reproductive doctors and oncologists to help such patients get pregnant safely as soon as *** this article,we will review the latest progress in conservative treatment and candidates for fertility preservation,application of molecular detection,the fertility outcome and follow-up treatment which aims to stimulate more thinking.

关键词： Endometrial cancer Atypical endometrial hyperplasia fertility preservation Molecular detection

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fertility preservation in female cancer patients

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The Chinese-German Journal of Clinical Oncology 2011年第1期10卷 1-8页

作者： Rumana Jafarey Reproductive Medical Centre Renmin Hospital of Wuhan University

Cancer is not rare in younger women of reproductive age therefore the preservation of fertility among them has become a significant concern due to aggressive cancer therapy they must *** different strategies for fertility preservation are available in patients at ***,many of these available techniques are still experimental and have limited clinical *** ethical principle,better interdisciplinary cooperation between clinicians and patients,appropriate counseling and further research on cryopreservation and transplantation techniques may enhance their success to preserve fertility of young cancer *** this article,the existing and emerging fertility preserving strategies in young cancer female as well as their safety and ethical issues are discussed.

关键词： cancer transplantation cryopreservation fertility preservation

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Gonadal damage and options for fertility preservation in female and male cancer survivors

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Asian Journal of Andrology 2006年第5期8卷 515-533页

作者： Theodoros Maltaris Heinz Koelbl Rudolf Seufert Franklin Kiesewetter Matthias W. Beckmann Andreas Mueller Ralf Dittrich Department of Obstetrics and Gynecology Johannes Gutenberg University Mainz D-55124 Germany Division of Andrology Erlangen University Hospital University of Erlangen-Nuremberg Erlangen Germany Department of Obstetrics and Gynecology Erlangen University Hospital University of Erlangen-Nuremberg Erlangen Germany

It is estimated that in 2010, 1 in every 250 adults will be a childhood cancer survivor. Today, oncological surgery, radiotherapy and chemotherapy achieve relatively high rates of remission and long-term survival, yet are often detrimental to fertility. Quality of life is increasingly important to long-term survivors of cancer, and one of the major quality-of-life issues is the ability to produce and raise normal children. Developments in the near future in the emerging field of fertility preservation in cancer survivors promise to be very exciting. This article reviews the published literature, discusses the effects of cancer treatment on fertility and presents the options available today thanks to advances in assisted-reproduction technology for maintaining fertility in male and female patients undergoing this type of treatment. The various diagnostic methods of assessing the fertility potential and the efficacy of in vitro fertilization （IVF） after cancer treatment are also presented.

关键词： reproduction cryopreservation male infertility semen preservation fertility preservation cancer treatment ovarian tissue

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