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Novaferon Effectively Inhibits Ancestral SARS-CoV-2 and Omicron Variant in Vitro,2022

China CDC weekly 2022年第23期4卷 509-512页

作者： Fei Ye Baoying Huang Li Zhao Yao Deng Jiao Ren Wenjie Tan National Health Commission(NHC)Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:To identify Novaferon(Nova),a novel recombinant protein of interferon(IFN)-α,antiviral activity against ancestral severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and Omicron variant in ***:Vero cells were infected with SARSCoV-2 and Omicron variant in a biosafety level-3 *** viral replications were accessed using quantitative real-time reverse transcription polymerase chain reaction(RT-PCR).Results:Results demonstrated that Nova has effective inhibition against ancestral SARS-CoV-2 and Omicron variant in ***:The in vivo effects of Nova need to be further tested in animal *** large-scale randomized double-blind clinical trials are needed to reveal its potentially clinical application.

关键词： feron interferon clinical

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LIVER AND BILIARY SYSTEM

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China Medical Abstracts(Internal Medicine) 1995年第2期12卷 99-104页

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Hepatitis

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外科研究与新技术 1995年第2期 100-102页

950335 Preliminary study on the treatment of chil-dren HBV associated glomerulonephritis with humanrecombinant α1 interferon（rhiFNα1）.FANG Lijun（方利君）,et *** Hosp,Shanghai Med Univ,Shang-hai,*** J Nephrol 1994;10（6）:*** cases of HBV associated glomerulonephritis（HBV-GN） are treated by human recombinant inter-feron （rhIFNα1） made in *** of these cases havemanifestation of nephrotic *** clinicalcharacteristics,pathological findings and