检索结果-南通市图书馆

MPDZ variants associated with epilepsies and/or febrile seizures and the individualized genotype-phenotype correlation

引用

Genes & Diseases 2024年第4期11卷 124-127页

作者： Junxia Luo Yun Li Yong Lv Xin Li Bing Qin Chuanfang Cheng Xiaorong Liu Weiping Liao Jie Wang Zaifen Gao Department of Epilepsy Center Children's Hospital Affiliated to Shandong UniversityJinanShandong 250022China Department of Epilepsy Center Jinan Children's HospitalJinanShandong 250022China Department of Brain Function and Neuroelectrophysiology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Pediatrics The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)HefeiAnhui 230001China Department of Pediatrics The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Epilepsy Center and Department of Neurosurgery The First Affliated Hospital of Jinan UniversityGuangzhouGuangdong 510630China Department of Cardiology The Second Afiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University GuangzhouGuangdong 510260China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China GuangzhouGuangdong 510260China

The multiple PDZ domain crumbs cell polarity complex component gene(MPDZ;MIM:603785),is highly expressed in the brain across the whole lifespan.It encodes the multiple PDZ domain protein,which is a member of the NMDAR signaling complex that may play a role in the control of AMPAR potentiation and synaptic plasticity in excitatory synapses."Previously,MPDZ variants have been demonstrated to be associated with autosomal recessive congenital hydrocephalus-2(HYC2;MIM:615219)which is commonly complicated by brain abnormalities and developmental delay.Seizures were reported in only one case.The association between MPDz and epilepsy requires clarification.

关键词： epilepsy febrile congenital

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Seroprevalence of dengue virus among adults presenting with acute febrile illness at a tertiary care hospital in South India

引用

Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 95-97页

作者： Lavanya Mohanam Priyadarshini Shanmugam Department of Microbiology Chettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkamChennai 603103India

Dengue virus,a member of the Flavivirus genus in the Flaviviridae family,has four serotypes(DEN-1 to DEN-4),and is responsible for both mild and severe dengue fever(dengue hemorrhagic fever and dengue shock syndrome)[1].Dengue cases are under reported in India and the cases are treated clinically based on the clinical triage of symptoms[2].Nonstructural protein(NS1)antigen is a highly conserved glycoprotein found in Flavivirus group such as Dengue,Zika,and Japanese encephalitis virus.Simultaneous detection of NS1 antigen,IgM and IgG antibody in a single cassette is used for testing primary and secondary dengue infection.Early diagnosis of disease progression associated with severe dengue and accessibility to appropriate medical care reduces severe dengue fatality rates to less than 1%.This retrospective study,conducted from January 2021 to December 2021 in the tertiary care hospital,South India,was aimed to determine the seroprevalence of dengue adult patients with acute febrile illness.

关键词： febrile acute diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Next-generation Sequencing Study of Pathogens in Serum from Patients with febrile Jaundice in Sierra Leone

引用

Biomedical and Environmental Sciences 2019年第5期32卷 363-370页

作者： ZHANG Yi YE Fei XIA Lian Xu ZHU Ling Wei IDRISSA Laybohr Kamara HUANG Ke Qiang ZHANG Yong LIU Jun BRIMA Kargbo WANG Ji LIANG Mi Fang SONG Jing Dong MA Xue Jun WU Gui Zhen National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Sierra Leone-China Friendship Biological Safety Laboratory FreetownSierra-Leone National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Chinese Center for Disease Control and Prevention Beijing 102206China Sierra Leone Ministry of Health and Sanitation Freetown Sierra-Leone Key Laboratory of Medical Virology National Health and Family Planning CommissionNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective People in Western Africa suffer greatly from febrile jaundice, which is caused by a variety of pathogens. However, yellow fever virus(YFV) is the only pathogen under surveillance in Sierra Leone owing to the undeveloped medical and public health system there. Most of the results of YFV identification are negative. Elucidation of the pathogen spectrum is required to reduce the prevalence of febrile jaundice. Methods In the present study, we used Ion Torrent semiconductor sequencing to profile the pathogen spectrum in archived YFV‐negative sera from 96 patients in Sierra Leone who presented with unexplained febrile jaundice. Results The most frequently identified sequencing reads belonged to the following pathogens: cytomegalovirus(89.58%), Epstein‐Barr virus(55.21%), hepatitis C virus(34.38%), rhinovirus(28.13%), hepatitis A virus(20.83%), coxsackievirus(10.42%), Ebola virus(8.33%), hepatitis E virus(8.33%), lyssavirus(4.17%), leptospirosis(4.17%), chikungunya virus(2.08%), Crimean‐Congo hemorrhagic fever virus(1.04%), and hepatitis B virus(1.04%). Conclusion The distribution of sequencing reads suggests a broader spectrum of pathogens for consideration in clinical diagnostics and epidemiological surveillance in Sierra Leone.

关键词： Sierra Leone febrile jaundice Next‐generation sequencing Virus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Viral and Bacterial Etiology of Acute febrile Respiratory Syndrome among Patients in Qinghai, China

引用

Biomedical and Environmental Sciences 2019年第6期32卷 438-445页

作者： LIU Gao Shan LI Hong ZHAO Sheng Cang LU Rou Jian NIU Pei Hua TAN Wen Jie NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Center for Disease Control and Prevention of Qinghai Province Xining 810007 Qinghai China

Objective This study was conducted to investigate the viral and bacterial etiology and epidemiology of patients with acute febrile respiratory syndrome(AFRS) in Qinghai using a commercial routine multiplex-ligation-nucleic acid amplification test(NAT)-based assay. Methods A total of 445 nasopharyngeal swabs specimens from patients with AFRS were analyzed using the RespiFinderSmart22 kit(PathoFinder BV, Netherlands) and the LightCycler 480 real-time PCR system. Results Among the 225(225/445, 51%) positive specimens, 329 positive pathogens were detected, including 298(90.58%) viruses and 31(9%) bacteria. The most commonly detected pathogens were influenza virus(IFV;37.39%;123/329), adenovirus(AdV;17.02%;56/329), human coronaviruses(HCoVs;10.94%;36/329), rhinovirus/enterovirus(RV/EV;10.03%;33/329), parainfluenza viruses(PIVs;8.51%;28/329), and Mycoplasma pneumoniae(M. pneu;8.51%;28/329), respectively. Among the co-infected cases(17.53%;78/445), IFV/AdV and IFV/M. pneu were the most common co-infections. Most of the respiratory viruses were detected in summer and fall. Conclusion In our study, IFV-A was the most common respiratory pathogen among 22 detected pathogens, followed by AdV, HCoV, RV/EV, PIV, and M. pneu. Bacteria appeared less frequently than viruses, and co-infection was the most common phenomenon among viral pathogens. Pathogens were distributed among different age groups and respiratory viruses were generally active in July, September, and November. Enhanced surveillance and early detection can be useful in the diagnosis, treatment, and prevention of AFRS, as well as for guiding the development of appropriate public health strategies.

关键词： Acute febrile respiratory syndrome Viral and bacterial etiology Prevalence Seasonal distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

febrile infants:written guidelines to reduce non-essential hospitalizations

引用

World Journal of Pediatrics 2021年第5期17卷 555-556页

作者： Ji Yoon Oh Soo-Young Lee Department of Pediatrics Bucheon St.Mary's HospitalCollege of MedicineThe Catholic University of Korea327 Sosa-roWonmi-guBucheon 14647.Republic of Korea

Management of febrile infants,especially those younger than 3 months of age,is of clinical importance due to the relatively high risk of serious bacterial infection(SBI),such as bacterial meningitis,bacteremia,or urinary tract infection(UTI)[1].Fortunately,reliable guidelines for assessing the risk of SB I in febrile infants have been developed to help determine whether an infant should be hospitalized,undergo lumbar puncture,or be treated with antibiotics[2].However,many hospitals do not have written institutional guidelines,so clinicians often make decisions based on their own experience and knowledge[3-5].For a consistent approach to febrile infants,our hospital plans to introduce written guidelines.In this study,we estimated the expected effects of these guidelines and compared our data with the results of previous domestic studies.

关键词： febrile infection urinary

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Malaria helminth co-infections and their contribution for aneamia in febrile patients attending Azzezo health center,Gondar,Northwest Ethiopia:a cross sectional study

引用

Asian Pacific Journal of Tropical Medicine 2012年第10期5卷 803-809页

作者： Abebe Alemu Yitayal Shiferaw Aklilu Ambachew Halima Hamid School of Biomedical and Laboratory Sciences.College of Medicine and Health Sciences University of GondarGondarEthiopia

Objective:To assess the prevalence of malaria helminth co-infections and their contribution for aneamia in febrile patients attending Azzezo health center,Gondar,Northwest Ethiopia. Methods:A cross section study was conducted among febrile patients attending Azezo health center from February-March 30,2011.Convenient sampling technique was used to select 384 individuals.Both capillary blood and stool were collected.Giemsa stained thick and thin blood film were prepared for identification of Plasmodium species and stool sample was examined by direct wet mount and formalin-ether concentration technique for detection of intestinal helminthes parasites.Haemoglobin concentration was determined using a portable haemoglobin spectrophotometer,Hemocue Hb 201 analyzer.Results:Out of 384 febrile patients examined for malaria parasites,44(11.5%) individuals were positive for malaria parasites,of which Plasmodium vivax accounted for 75.0%(33),Plasmodium falciparum for 20.5%(9| infectious,whereas two person (4.5%) had mixed species infection.Prevalence of malaria was higher in males(28) when compared with prevalence in females(16).More than half(207,53.9%) of study participants had one or more infection.Prevalence was slightly higher in females(109,52.7%) than in males(98,47.3%).About helminths,Ascaris lumbricoides was the predominant isolate(62.1%) followed by hookworms(18.4%). Only 22 participants were co-infected with malaria parasite and helminths and co-infection with Ascaris lumbricoides was predominant(45.0%).The prevalence of anemia was 10.9%and co-infection with Plasmodium and helminth parasites was significantly associated with(P<0.000 1) higher aneamia prevalence compared to individuals without any infection.Conclusions: Prevalence of malaria and soil transmitted helminths is high and the disease is still major health problem in the study area.Hence,simultaneous combat against the two parasitic infections is very crucial to improve health of the affected communities in economically developing countries.

关键词： Malaria Helminth Aneamia febrile

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Winter is coming:care of the febrile children in the time of COVID-19

引用

World Journal of Pediatrics 2021年第1期17卷 6-7页

作者： Nicole Gerber Jonathan S.Farkas Adam J.Ratner Weill Cornell Medical Center New York Presbyterian525 East 68th StreetM-131New YorkNY 10021USA Department of Emergency Medicine Division of Pediatric Emergency Medicine525 East 68th StreetM130New YorkNY 10021USA New York University Langone Health/Bellevue Hospital Center 462 First AveNew YorkNY 10016USA

In the pediatric emergency department(PED),winter seems to arrive earlier each year.After the broken bones and lac-erations of the summer,the winter season brings fevers and respiratory illnesses.Fever is our bread and butter-it is the most common reason for PED visits[1].Fever phobia is ingrained in our society[2].In the pre-vaccine era,a febrile child was cause for concern;those who were ill-appearing had high rates of bacterial meningitis,and even well-appear-ing children could not be rapidly discharged.Occult bac-teremia was a common condition in well-appearing young febrile children and frequently required laboratory evalua-tion and treatment with empiric antibiotics[3].

关键词： febrile winter children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sero diagnosis of dengue activity in an unknown febrile outbreak at the Siliguri Town,District Darjeeling,West Bengal

引用

Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 364-366页

作者： Debjani Taraphdar Arindam Sarkar Mihir Kumar Bhattacharya Shyamalendu Chatterjee ICMR virus unit GB-41st FloorID & BG Hospital57Dr.S.C.Banerjee RoadBeliaghataKolkata-700010 India National Institute of Cholera and Enteric Diseases P-33 C.I.T.RoadScheme XMBeliaghataKolkataIndia

Objective:To investigate the outbreak of unknown fever at Siliguri town,Darjeeling District on request from the State Health Department,Government of West Bengal.Methods: Investigations were made to the affected wards,Sub Divisional Hospital and the nursing homes of Siliguri Town.Duration of illness was 3-5 days.Interesting observations were made in some cases which had gastrointestinal disorders with high serum glutamate pyruvate transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SCOT) levels.A total of 69 blood samples and 7 throat swabs(in Minimum Essential Media) were collected and brought to the ICMR Virus Unit, Kolkata for analysis.Mosquitoes from different affected areas were collected for the identification of the definite vector.Results:Amongst the 69 blood samples,42(60.86%) were positive to IgM antibody against dengue virus by Mac enzyme-linked immunosorbent assay(ELISA) test.No IgM antibody to Japanese encephalitis virus was detected among the collected blood samples.Based on the clinical symptoms,presence of IgM antibody to dengue virus and identification of Aedes mosquito,it amply proves that,the illness of those cases were due to dengue virus infection. Conclusions:Based on clinical-epidemiological observations of the investigations the possibility of a communicable disease of viral origin,the detection of IgM antibody and the identification of Aedes egypti,and the potential circulation of denge virus in Siliguri town for the first time were all suggested.

关键词： Sero diagnosis Dengue febrile West Bengal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Etiologies of tropical acute febrile illness in West Pahang, Malaysia: A prospective observational study

引用

Asian Pacific Journal of Tropical Medicine 2020年第3期13卷 115-122页

作者： Alif Adlan Mohd Thabit Mohd Hatta Abdul Mutalip Wan Mohd Rasis Wan Ahmad Kamil Mohd RamadhanMohd Din Mohan Arumugam Siti Sanaa Wan Azman Roslinda Jaafar Sathvinder Singh Gian Singh RafidahAbdullah Eida Nurhadzira Muhammad Nor Asiah Muhamad Department of Medicine Hospital Bentong BentongPahangMalaysia Institute for Public Health National Institute of HealthMalaysiaMinistry of Health MalaysiaSelangorMalaysia Department of Medicine Hospital Sultan Haji Ahmad Shah TemerlohPahangMalaysia Department of Pathology Hospital Sultan Haji Ahmad Shah TemerlohPahangMalaysia Department of Medicine Hospital Kuala Lipis Kuala LipisPahangMalaysia

Objective: To determine the etiologies of tropical acute febrile illness(TAFI) in West Pahang, Malaysia and to investigate morbidity and mortality factors in relation to TAFI. Methods: A multicenter prospective cohort study was conducted between January and June 2016 in six district hospitals throughout the western part of Pahang State in Peninsular Malaysia. A total of 336 patients answered a standardized questionnaire and blood samples were collected for laboratory confirmation of infectious etiology. Descriptive analysis and logistic regression were performed to identify factors associated with TAFI. Results: A total of 336 patients were included. The patients were mainly Malays(70.2%), males(61.3%), aged(44.6±17.4) years, with more than half(58.9%) presenting with gastrointestinal symptoms. The majority were diagnosed with dengue(35.7%) while malaria(4.5%) was the least frequent. The in-hospital mortality due to TAFI was 9.2%. Patients with meliodosis had five times higher mortality [Adjusted OR: 5.002, 95% CI:(1.233, 20.286)]. Patients with comorbidities such as cardiovascular symptoms(P<0.001) and renal replacement therapy initiation(P<0.001) were significantly associated with in-hospital mortality in all TAFI. Conclusions: The etiology of TAFI in the western Pahang includes dengue, leptospirosis, malaria and melioidosis, which carry the highest risk of in-hospital mortality. The presence of cardiovascular symptoms may be used to assess the disease severity in TAFI, but more studies are needed in the future.

关键词： Comorbidities Mortality Tropical acute febrile illness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arboviruses emerging in Peru: Need for early detection of febrile syndrome during El Ni?o episodes

引用

Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 796-797页

作者： Derek Tantaléan-Yépez José Sánchez-Carbonel Gabriela Ulloa-Urizar Diego Espinoza- Morales Miguel Angel Aguilar-Luis Wilmer Silva-Caso María J.Pons Juana del Valle- Mendoza School of Medicine Health Sciences Faculty Universidad Peruana de Ciencias Aplicadas (UPC) Research Center and Innovation of the Health Sciences Faculty Universidad Peruana de Ciencias Aplicadas (UPC)

The presence of El Ni?o Southern Oscillation(ENSO)implies the presence of fluctuating rains in coastal areas and these changes influence the occurrence of febrile syndromes outbreaks.In Peru,Aedes aegypti is the vector responsible for various viruses such as the dengue,Zika,chikungunya,which is distributed in 18 Peruvian departments.These viruses cause similar clinical characteristics in the host and for this reason rapid,sensitive and specific diagnostic tests are needed so that the patient can receive timely treatment.

关键词： febrile syndrome Dengue Chikungunya Zika

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：