检索结果-南通市图书馆

Repairing whole facial nerve defects with xenogeneic acellular nerve grafts in rhesus monkeys

Neural Regeneration Research 2022年第5期17卷 1131-1137页

作者： Guo-Chen Zhu Da-Jiang Xiao Bi-Wen Zhu Yan Xiao Department of Otorhinolaryngology-Head and Neck Surgery Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical UniversityWuxiJiangsu ProvinceChina Department of Otorhinolaryngology-Head and Neck Surgery Affiliated Wuxi Clinical College of Nantong UniversityWuxiJiangsu ProvinceChina College of Animal Science&Technology Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong ProvinceChina Department of Pathology Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical UniversityWuxiJiangsu ProvinceChina

Acellular nerve allografts conducted via chemical extraction have achieved satisfactory results in bridging whole facial nerve defects clinically,both in terms of branching a single trunk and in connecting multiple branches of an extratemporal ***,in the clinical treatment of facial nerve defects,allogeneic donors are *** this experiment,we exposed the left trunk and multiple branches of the extratemporal segment in six rhesus monkeys and dissected a gap of 25 mm to construct a monkey model of a whole left nerve *** monkeys were randomly assigned to an autograft group or a xenogeneic acellular nerve graft *** the autograft group,the 25-mm whole facial nerve defect was immediately bridged using an autogenous ipsilateral great auricular nerve,and in the xenogeneic acellular nerve graft group,this was done using a xenogeneic acellular nerve graft with *** of facial symmetry,nerve-muscle electrophysiology,retrograde transport of labeled neuronal tracers,and morphology of the regenerated nerve and target muscle at 8 months postoperatively showed that the faces of the monkey appeared to be symmetrical in the static state and slightly asymmetrical during facial movement,and that they could actively close their eyelids *** degree of recovery from facial paralysis reached House-Brackmann grade II in both *** muscle action potentials were recorded and orbicularis oris muscles responded to electro-stimuli on the surgical side in each *** Gold-labeled neurons could be detected in the facial nuclei on the injured *** staining showed abundant neurofilament-200-positive axons and soluble protein-100-positive Schwann cells in the regenerated nerves.A large number of mid-graft myelinated axons were observed via methylene blue staining and a transmission electron *** together,our data indicate that xenogeneic acellular nerve grafts from minipigs are safe and effec

关键词： acellular nerve compound muscle action potentials facial nerve defect facial symmetry monkey nerve graft nerve regeneration retrograde labeling test synaptophysin xenogeneic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

facial reanimation with interposition nerve graft or masseter nerve transfer:a comparative retrospective study

引用

Neural Regeneration Research 2022年第5期17卷 1125-1130页

作者： Wen-Jin Wang Wei-Dong Zhu Mathias Tremp Gang Chen Zhao-Yan Wang Hao Wu Wei Wang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Head and Neck Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases ShanghaiChina Ear Institute Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Plastic ReconstructiveAesthetic and HandsurgeryUniversity Hospital BaselBaselSwitzerland

Both interposition nerve grafts and masseter nerve transfers have been successfully used for facial reanimation after irreversible injuries to the cranial portion of the facial ***,no comparative study of these two procedures has yet been *** this two-site,twoarm,retrospective case review study,32 patients were *** these,17 patients(eight men and nine women,mean age 42.1 years)underwent interposition nerve graft after tumor extirpation or trauma between 2003 and 2006 in the Ear Institute,School of Medicine,Shanghai Jiao Tong University,China,and 15 patients(six men and nine women,mean age 40.6 years)underwent masseter-to-facial nerve transfer after tumor extirpation or trauma between November 2010 and February 2016 in Shanghai Ninth People's Hospital,*** patients achieved House-Brackmann III recovery after masseter nerve repair than interposition nerve graft repair(15/15 vs.12/17).The mean oral commissure excursion ratio was also higher in patients who underwent masseter nerve transfer than in patients subjected to an interposition nerve *** findings suggest that masseter nerve transfer results in strong oral commissure excursion,avoiding obvious synkinesis,while an interposition nerve graft provides better resting *** study was approved by the Institutional Ethics Committee,Shanghai Ninth People's Hospital,China(approval ***9 H-2019-T332-1)on December 12,2019.

关键词： facial palsy facial reanimation facial symmetry House-Brackmann score interposition masseter nerve nerve graft oral commissure excursion resting symmetry synkinesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：