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Monitoring magnesium degradation using microdialysis and fabric-based biosensors

Science China Materials 2018年第4期61卷 643-651页

作者： M.Su Natasha Radha S.P.Malon Dedy H.B.Wicaksono Emma P.Córcoles Hendra Hermawan Faculty of Biosciences and Medical Engineering Universiti Teknologi Malaysia Faculty of Science and Technology Universiti Kebangsaan Malaysia Department of Biomedical Engineering Faculty of Life Sciences and Technology Swiss German University Instituto de Microelectrónica de Barcelona (IMB-CNM) CSIC Campus UAB Department of Mining Metallurgical and Materials Engineering & CHU de Québec Research Center

This paper describes the development of a monitoring system capable of detecting the concentration of magnesium ions(Mg^(2+)) released during the degradation of magnesium implants. The system consists of a microdialysis probe that samples fluid adjacent to the implant and a catalytic biosensor specific to Mg^(2+)ions. The biosensor was fabricated on a cotton fabric platform, in which a mixture of glycerol kinase and glycerol-3-phosphate oxidase enzymes was immobilized on the fabric device via a simple matrix entrapment technique of the cotton fibers. Pure magnesium was used as the implant material. Subsequently, the concentration of ions released from the degradation of the magnesium specimen in Ringer's solution was evaluated using cyclic voltammetry technique. The device demonstrated a pseudo-linear response from 0.005 to 0.1 mmol L^(-1) with a slope of 67.48 μA mmol^(-1) L. Detectable interfering species were lesser than 1%indicating a high selectivity of the fabric device. Furthermore,the device requires only 3 μL of fluid sample to complete the measurement compared to spectroscopic method(±50 μL),hence providing a higher temporal resolution and reduced sampling time. The system could potentially provide a real time assessment of the degradation behavior, a new studied aspect in biodegradable metals research.

关键词： biodegradable metal biosensor fabric device magnesium microdialysis

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