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针刺研究 2001年第3期26卷 193-194页

作者：张蔚婷金真罗非张磊崔国红曾亚伟韩济生北京大学神经科学研究所北京100083 解放军306医院磁共振室北京100101

Acupuncture can mobilize endogenous opioid system and produce analgesia. However, there is some variability of the analgesic effect between individuals, which is related with cholecystokin level of the subject. In the present study, we try to use functional magnetic resonance imaging (fmri) to address the question by which neuropathways CCK influences acupuncture induced analgesia. Two different frequencies of transcutaneous electric acupoint stimulation (TEAS) were administered to normal human body. TEAS was used instead of traditional acupuncture for its similar analgesic effect and convenience of parameter adjustment. Our previous studies have indicated that low and high frequency TEAS generated effects through different neuropathways, in which some nuclei of midbrain, thalamus and hypothalamus played an important role. 25 healthy volunteers were randomly divided into two groups to receive low and high frequency TEAS respectively. Data from functional MRI scanning (EPI sequence, TR=3000 ms, TE=45 ms, Flip angle: 90°) were collected at the same time of stimulation. Basal and after TEAS pain thresholds were measured by radiant heat withdrawal test 1～3 days before fmri examination and changes of pain threshold were calculated as the index of analgesic effect of TEAS. Functional data were processed with cross correlation of timecourse and stimulation curve after registration, normalization and detrending. The averaged signal intensity of every interested region was linear regressed according to the change of pain threshold. We found that in low frequency TEAS group, activation intensity of contralateral primary and supplementary motor areas (MI and SMA), bilateral secondary somatosensory area (SⅡ), contralateral thalamus and anterior cingulate cortex (BA 24), ipsilateral superior temporal gyrus, insula had a significant linear correlation with the change of pain threshold. Furthermore, the signal intensity of bilateral hippocampus and the change of pain threshold had

关键词：针刺疗法经皮穴位电刺激大脑 fmri信号镇痛

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国外事件相关功能磁共振成像研究概况

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心理科学 2001年第6期24卷 729-730页

作者：何华张武田苏州大学应用心理学研究所 215021 中科院心理学研究所 100101

尽管正电子放射层描(Positron Emission Tomography,PET)在过去的15年中是主要的脑成像技术,但最近几年,功能磁共振成像(functional Magnetic Resonance Imaging,fmri)在认知神经科学中所具有的优势已超过PET.因为,相对于PET,fmri具有如下优势:1)不需注射放射性同位素的无损伤成像;2)有较好的时、空间分辨率.fmri已迅速成为研究行为神经基础的一种有力的技术工具.本文将介绍国外新出现的一种成像实验设计方法--事件相关功能磁共振成像(Event-Related fmri)和相关的应用研究.

关键词：外国事件相关功能磁共振成像研究概况 fmri信号 “组块” 随机顺序电子放射层描

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