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Distribution of pathogenic bacteria and antimicrobial sensitivity of eye infections in Suzhou

International Journal of Ophthalmology(English edition) 2024年第4期17卷 700-706页

作者： Li Zhang Hai-Zhang You Guo-Hui Wang Wei Xu Jian-Shan Li Qing-Liang Zhao Shu Du Department of Hospital-Acquired infection Control Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Administrative Office Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Clinical Laboratory Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Pharmacy Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Corneal and Lacrimal Passage Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Fundus Diseases and Ocular Trauma Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina

AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial ***:The clinical data of 155 patients were retrospectively collected in this study,and the pathogenic bacteria species and drug resistance of each pathogenic bacteria were ***:Among the 155 patients(age from 12 to 87 years old,with an average age of 57,99 males and 56 females)with eye infections(160 eyes:74 in the left eye,76 in the right eye and 5 in both eyes,all of which were exogenous),71(45.81%)strains were gram-positive bacteria,23(14.84%)strains were gram-negative bacteria and 61(39.35%)strains were ***-positive bacteria were highly resistant to penicillin and erythromycin(78.87%and 46.48%respectively),but least resistant to vancomycin at ***-negative bacteria were highly resistant to cefoxitin and compound sulfamethoxazole(100%and 95.65%respectively),but least resistant to meropenem at *** of the resistance of gram-positive and gram-negative bacteria to some drugs revealed statistically significant differences(Pinfection strains showed that Staphylococcus epidermidis was the most common strain in the conjunctiva,cornea,aqueous humor or vitreous body and other eye ***,Fusarium and Pseudomonas aeruginosa were also among the most common strains of conjunctival and corneal ***:Gram-positive bacteria are the dominant bacteria in eye infections,followed by gram-negative bacteria and *** the resistance of gramnegative bacteria to multiple drugs,monitoring of bacteria should be strengthened in eye bacterial infections for effective prevention and control to reduce complications caused by eye infections.

关键词： eye infection pathogenic bacteria drug resistance antimicrobial sensitivity test

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Effect of corneal graft diameter on therapeutic penetrating keratoplasty for fungal keratitis

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 698-703页

作者： Cui Li Gui-Qiu Zhao Cheng-Ye Che Jing Lin Na Li Wen-Yan Jia Qiu-QiuZhang Nan Jiang Li-Ting Hu Department of Ophthalmology the Affiliated Hospital of Medical College Qingdao University Tengzhou Central People's Hospital

AIM: To evaluate the effect of corneal graft diameter on therapeutic penetrating keratoplasty(PKP) for fungal keratitis. METHODS: A total of 116 patients (116 eyes) suffered from fungal keratitis underwent PKP at the Affiliated Hospital of Medical College Qingdao University from May 2006 to May 2010. They were divided into two groups according to the corneal graft diameter. 64 eyes' corneal graft diameter was 8.00mm or larger and 52 eyes' graft diameter was smaller than 8.00mm. The follow-up time was 2 years. The postoperative visual acuity and complications were documented and compared. RESULTS: Sixty-two (96.88%) eyes and fifty (96.15%) eyes preserved eyeballs respectively in two groups. There was no statistical difference in postoperative visual acuity (P = 0.961), corneal graft dear rate (P=0.132) or the incidence of recurred fungal infection (P=0.770) between two groups. But there was a higher incidence of graft rejection (P=0.020) and secondary glaucoma (P=0.039) in group with corneal graft diameter 8.00mm or larger. CONCLUSION: PKP is an effective treatment approach for fungal keratitis. There is a higher incidence of complications in large-diameter PKP for fungal ***, preventive and therapeutic measures can improve the prognosis.

关键词： keratoplasty penetrating eye infection fungal corneal graft

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Natamycin in the treatment of fungal keratitis : a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 597-602页

作者： Sheng Qiu Gui-Qiu Zhao Jing Lin Xue Wang Li-Ting Hu Zhao-Dong Du Qian Wang Cheng-Cheng Zhu Department of Ophthalmology Medical College Qingdao University Department of Ophthalmology the Affiliated Hospital of Qingdao University

AIM: To review published clinical studies examining the effect of natamycin in the treatment of fungal ***: We selected the publications in CENTRAL,MEDLINE, EMBASE, CNKI, and CBM. This study systematically reviewed published randomized controlled trials(RCTs) that compared natamycin to other antifungal agents, and conducted feasible Meta-analysis of efficacy results using Revman 5.2 ***: We included seven trials which were mainly carried out in developing countries of Asia, with five trials conducted in India, one each in China and Bangladesh. A total of 804 participants were randomized to following comparisons: 2% econazole versus 5%natamycin showed little difference in the effects of treatment of fungal keratitis [RR =0.99, 95% confidence interval(CI), 0.8 to 1.21]; chlorhexidine gluconate versus5% natamycin indicated that the results on healing of the ulcer at 21 d was less conclusive(RR=0.77, 95% CI, 0.55 to 1.08; I2=0%); 1% voriconazole versus 5% natamycin suggested that natamycin treatment appeared to be significantly better outcomes than voriconazole(regression coefficient =-0.18 log MAR; 95% CI,-0.30 to-0.05; P =0.006), especially in Fusarium cases(regression coefficient=-0.41 log MAR; 95% CI,-0.61 to-0.20; P <0.001);natamycin versus fluconazole showed a significant difference in cure rate(χ2=5.048, P <0.05) and natamycin group was more effective than fluconazole in average period of therapy(t =7.94, P <0.01).CONCLUSION: Natamycin was a preferable choice in the treatment of fungal keratitis, especially in the early period of Fusarium cases.

关键词： eye infection fungal natamycin Metaanalysis

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