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Subconjunctival trypsin injection for anterior chamber fibrin exudates in eyes with globe rupture following vitrectomy

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International Journal of Ophthalmology(English edition) 2024年第11期17卷 2037-2044页

作者： Shu-Wen Lu Hao-Yu Li Xin-Min Li Chao Ma Xian Li Qiu-Ming Hu Department of Ophthalmology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangsha 410021Hunan ProvinceChina Hunan Clinical Research Centre of Ophthalmic Disease Changsha 410021Hunan ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina School of Pharmacy and Optometry Faculty of BiologyMedicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Retina and Vitreous Jingliang Eye HospitalGuangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

AIM:To compare the safety and clinical outcomes of subconjunctival trypsin and dexamethasone(DEX)injections in the treatment of anterior chamber fibrin exudates in eyes with globe rupture following primary wound repair and ***:A retrospective analysis included 42 males and 10 females(mean age 46.0±6.0y,range 34 to 58y)who underwent primary wound sutures and vitrectomy for globe *** with pupil-covered fibrinous exudate or/and membrane in the anterior chamber were *** the first postoperative day,subconjunctival injections of either 5000 units(0.4 mL)of trypsin solution(n=25)or 0.5 mL(1 mg)DEX(n=27)were administered to accelerate exudate *** was assessed by observing break time and partial absorption of the fibrin exudate *** and comfort were evaluated by monitoring intraocular pressure(IOP),allergy,pain,and foreign body ***:Both groups achieved 1/3 absorption of the anterior chamber fibrin exudate membrane,but the trypsin group exhibited shorter break time and partial absorption time compared to the DEX group(Pfibrin exudate membrane with a more comfortable process in treating pupil-covered fibrinous exudate or/and membrane after vitrectomy for globe rupture.

关键词： globe rupture vitrectomy exudative fibrin membrane trypsin dexamethasone

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