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Roots extracts of Adenophora triphylla *** improve obesity in 3T3-L1 adipocytes and high-fat diet-induced obese mice

Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 879-886页

作者： Dong-Ryung Lee Young-Sil Lee Bong-Keun Choi Hae Jin Lee Sung-Bum Park Tack-Man Kim Han Jin Oh Seung Hwan Yang Joo-Won Suh NutraPham Tech Center for Nutraceutical and Pharmaceutical Materials Myongji University Interdisciplinary Program of Biomodulation Myongji University DONG IL Pharmtec Department of Family Medicine.VIEVIS NAMUH Hospital

Objective:To investigate the anti-obesity activity and the action mechanism of the roots of Adenophora triphylla *** extract(ATE) in high-fat diet(HFD)-induced obese mice and 3T3-LI ***:The roots of Ademption triphylla were extracted with 70%*** demonstrate the compounds,linoleic acid was analyzed by using gas chromatography:and the anti-obesity effects and possible mechanisms of ATE were examined in 3T3-L1 adipocytes and HFD-induced obese ***:Treatment with ATE inhibited the lipid accumulation without cytotoxicity in 3T3-L1 ***,200 and 400 mg/kg ATE treatment significantly decreased the body weight gain,white adipose tissues(WATs) weight and plasma triglyceride level,while 100 and 200 mg/kg ATE treatment increased the plasma high-density lipoprotein cholesterol level in the HFD-induced obese mice,as compared with the HFD *** with 200 and 400 mg/kg ATE also lowered the size of adipocytes in adipose tissue and reduced the lipid accumulation in *** treatment showed significantly lower expression level of adipogenesis-relatcd proteins,such as peroxisome proliferator-activated receptor y,fatty acid binding protein(aP2),fatty acid synthase in 3T3-L1 adipocytes;and furthermore,decreased peroxisome proliferatoractivated receptor γ,aP2,fatty acid synthase,sterol regulatory element binding protein-1c,and lipoprotein lipase mRNA expression levels in WAT of the HFD-induced obese ***:These results suggested that the ATE has an anti-obesity effect,which may be elicited by regulating the expression of adipogenesis and lipogenesis-related genes and proteins in adipocytes and WAT of the HFD-induced obese mice.

关键词： Roots of Adenophora triphylla var. japonica extrac

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Anticancer activity of Cyanothece sp. strain extracts from Egypt: First record

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Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 992-995页

作者： Nermin Adel El Semary Manar Fouda Department of Botany and Microbiology Faculty of Science Helwan University Department of Chemistry Faculty of Science Helwan University

Objective:To assess the anticancer activity of eight cyanobacterial hydrophilic extracts on Ehrlich ascites carcinoma cell ***:The cyanobacterial strains used in the investigation were collected from diverse habitats in *** initial cytotoxicity test of cyanobacterial hydrophilic extracts was carried out by MTT *** in vitro anticancer activity of the four most active extracts was performed on MCF-7 cells using sulforhodamine B *** and molecular techniques were used to characterise identity of the isolate from which the most potent cytotoxic extract was ***:extracts from four cyanobacterial strains had higher cytotoxic activities scoring76.68%,77.70%,76.70%and 74.45%,respectively.A considerable anticancer effect was only detected when the concentrated extracts were *** cyanobacterial extract gave the highest anticancer activity on human breast adenocarcinoma cell line(57.6%of inhibition)as compared to *** isolate was best-matched to Cyanothece *** sequence resemblance 98%to Cyanothece *** PCC7564 and the phylogenetic analysis confirmed its close identity to the Cyanothece ***:This is the first study to report the anticancer effect of aqueous extracts derived from the unicellular Cyanothece *** Egypt and its potential as a plausible candidate for future mass biotechnological applications.

关键词： Anticancer Cell line Cyanothece Hydrophilic extrac

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