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Active greeting technique: a mother-and-child catheter based technique to facilitate retrograde wire externalization in recanalization of coronary chronic total occlusion

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Science Bulletin 2018年第23期63卷 1565-1569页

作者： Junbo Ge Lei Ge Bin Zhang Xin Zhong Jianying Ma Leisheng Ru Tao Hu Juying Qian 无 Shanghai Institute of Cardiovascular Diseases Zhongshan HospitalFudan UniversityShanghai 200022China Institutes of Biomedical Sciences.Fudan University Shanghai 200032China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong General Hospital Guangzhou510080China Department of Cardiology Bethune International Peace HospitalShzjiazhuang 050082China Department of Cardiology Xijing HospitalXi'an 710032China Chronic Total Occlusion Club China

Although retrograde approach has greatly improved the success rate of percutaneous coronary intervention(PCI) for coronary chronic total occlusion(CTO), retrograde wire externalization still remains challenging and time-consuming in some cases. Cases utilizing ‘‘Active Greeting Technique(AGT)", a mother-and-child catheter based technique to facilitate retrograde wire externalization, were extracted from Chronic Total Occlusion Club, China(CTOCC) database. AGT was performed by deep intubation a mother-and-child catheter(GuidezillaTMextension, 4 or 5 Fr inner catheter, and etc.) in combination with either reverse controlled antegrade or retrograde subintimal tracking(CART) technique or retrograde wire crossing technique. A total of 111 patients with 112 CTO lesions treated with this technique were retrospectively analyzed. Reverse CART technique and retrograde wire crossing technique were performed in 90.2% and 9.8% of all procedures. The utilization of GuidezillaTMextension, 4 Fr, and 5 Fr inner catheter accounted for 94.6%, 3.6%, and 1.8%, respectively. externalization of retrograde wire was successful in all cases. No procedural complications were adjudicated to AGT. Complications independent of AGT included two target vessel perforations and two collateral perforations. No in-hospital major adverse cardiac events were found. AGT is a feasible and safe technique that facilitates retrograde wire externalization.

关键词： Percutaneous coronary intervention Chronic total occlusion Retrograde wire externalization Active greeting technique

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externalization AND INTERNALIZATION OF CARDIAC ENDOTHELIN RECEPTORS DURING DIFFERENT PHASES OF SEPSIS IN RAT

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Chinese Medical Sciences Journal 2001年第1期16卷 10-14页

作者：王晓红杨军董林旺庞永政苏静怡唐朝枢刘乃奎 InstituteofCardiovascularResearch theFirstHospitalofBeijingMedicalUniversityBeijing100034

To study the redistribution of endothelin- 1 (ET- 1) receptors in two subcellular organelles , the sarcolemmal membrane and the light vesicle, of rat heart during the progression of sepsis. Methods. Sepsis was induced by cecal ligation and puncture (CLP). ET1 receptor was assayed by using [125I]- ET1 binding. Marker enzyme activities, protein yield, and dry- to- wet weight ratio of cardiac membranes were measured. Results. Septic rat heart exhibited two distinct phases: an initial hyperdynamic phase( 9h after CLP; early stage of sepsis) followed by a hypodynamic (18h after CLP, late stage of sepsis) phase. [125I]- ET1 binding study showed that during early stage of sepsis, the Bmax of ET1 receptors was increased by 30％ in sarcolemma but decreased by 19％ in light vesicles, while during late stage of sepsis, the Bmax was decreased by 24％ in sarcolemma but increased by 38％ in light *** total binding of sarcolemma and light vesicles was increased by 25％ during early stage of sepsis but decreased by 17％ during late stage of sepsis. Conclusions. These data indicated that ET1 receptors in the rat heart were externalized from light vesicles to sarcolemmal membranes during early hyperdynamic phase while internalized from surface membranes to intracellular compartment during late hypodynamic phase of sepsis.

关键词： endothelial receptor sepsis externalization internalization

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INTRACELLULAR REDISTRIBUTION OF CARDIAC ENDOTHELIN- 1 RECEPTOR IN RAT DURING MYOCARDIAL HYPERTROPHY

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Chinese Medical Sciences Journal 2001年第2期16卷 86-92页

作者：王晓红齐永芬杨军佟利家庞永正唐朝枢 Institute of Cardiovascular Research First Hospital of Peking University Beijing 100034.

Objective. In a model of rat cardiac hypertrophy, the changes in the distribution of ET- 1 receptors in two subcellular fractions, the sarcolemma and the light vesicles during myocardial hypertrophy were studied. Methods. Cardiac hypertrophy was produced by placing a constricting clip around the suprarenal abdominal aorta of rats, and ET- 1 receptor was assayed with radioactive analysis method. Results. It was found that plasma and ventricular ET- 1 levels increased significantly on week 2 and week 4 of pressure overload. ET- 1 binding studies showed that during myocardial hypertrophy, the maximum binding capacity (Bmax) was increased by 41％ (P< 0.01) and 65％ (P< 0.01) in sarcolemma in H- 2 week and H- 4 week groups, but was decreased by 24％ (P< 0.01) and 21％ (P< 0.01) in light vesicles. The sum of Bmax of sarcolemmal and light vesicle fractions was increased by 33％ (P< 0.01) and 57％ (P< 0.01) in group H- 2 week and H- 4 week, respectively. Conclusion. ET- 1 receptors in rat heart were externalized from light vesicles to sarcolemma, which may contribute to the development of myocardial hypertrophy.

关键词： endothelin receptor hypertrophy externalization

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INTENSIFICATION OF GRASSLAND-BASED DAIRY PRODUCTION AND ITS IMPACTS ON LAND,NITROGEN AND PHOSPHORUS USE EFFICIENCIES

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Frontiers of Agricultural Science and Engineering 2021年第1期8卷 130-147页

作者： Jouke OENEMA Oene OENEMA Wageningen Plant Research Agrosystems Research6700 AA Wageningenthe Netherlands Wageningen Environmental Research 6700 AA Wageningenthe Netherlands

Many grassland-based dairy farms are intensifying production,i.e.,produce more milk per ha of land in response to the increasing demand for milk(by about 2%per year)in a globalized ***,intensive dairy farming has been implicated for its resources use,ammonia and greenhouse gas emissions,and eutrophication *** paper addresses the question of how the intensity of dairy production relates to N and P surpluses and use efficiencies on farms subjected to agri-environmental *** monitoring data were analyzed from 2858 grassland-based dairy farms in The Netherlands for the year *** farms produced on average 925 Mg·yr^(-1)*** production per ha ranged from30 Mg·ha^(-1)·yr^(-1).Purchased feed and manure export strongly increased with the level of *** of N and P at farm level remained constant and ammonia emissions per kg milk decreased with the level of *** conclusion,N and P surpluses did not differ much among dairy farms greatly differing in intensity due to legal N and P application limits and obligatory export of manure surpluses to other ***,N and P use efficiencies also did not differ among dairy farms differing in intensity provided the externalization of feed production was accounted *** paper provides lessons for proper monitoring and control of N and P cycling in dairy farming.

关键词： ammonia externalization feed forage maize front runners manure production milk yield nitrogen surplus

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企业隐性知识外部化过程中企业与员工的博弈分析

企业管理研究

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企业管理研究 2005年第11期

作者：司训练陈金贤李秉祥

企业构建核心竞争力的基础条件需要将企业内部隐性知识外部化，这一过程中存在着企业与员工的相互博弈。据此提出一个动态重复博弈模型，分析了企业与员工在隐性知识显性化进程中的博弈过程，探讨了企业与员工最佳博弈策略的选择，最后... 详细信息

企业构建核心竞争力的基础条件需要将企业内部隐性知识外部化，这一过程中存在着企业与员工的相互博弈。据此提出一个动态重复博弈模型，分析了企业与员工在隐性知识显性化进程中的博弈过程，探讨了企业与员工最佳博弈策略的选择，最后提出了基于博弈结果的政策设计原则。

关键词：隐性知识外部化动态博弈均衡价格 tacit knowledge externalization dynamic game equilibrium price

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城市产业差异、外部性与经济增长

区域与城市经济

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区域与城市经济 2016年第10期

作者：张维今李凯

集聚经济产生的外部性是城市经济增长的重要原因，但主要是MAR外部性还是Jacobs外部性起主导作用，学术界存在争议。利用中国285个地级以上城市2004-2013年的面板数据，从城市规模的角度入手，分析不同规模城市外部性与城市产业发展中... 详细信息

集聚经济产生的外部性是城市经济增长的重要原因，但主要是MAR外部性还是Jacobs外部性起主导作用，学术界存在争议。利用中国285个地级以上城市2004-2013年的面板数据，从城市规模的角度入手，分析不同规模城市外部性与城市产业发展中专业化和多样化对经济增长的影响。实证结果表明：从全国范围内来看，产业多样化和专业化均能对经济增长产生一定的促进作用，多样化和专业化不是完全对立的；对不同规模的城市来说，资本和劳动对经济增长有显著的正向影响，在小型城市中，劳动力的影响更显著，而城市规模越大，资本作用表现越明显；中小城市倾向于支持MAR外部性，大型城市倾向于支持Jacobs外部性。

关键词：城市规模外部性产业多样化专业化经济增长 city scale externalization diversification specialization economic growth

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对盗版及政府作用的经济学分析

出版工作

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出版工作 2003年第3期

作者：高山行江旭

本文运用经济学的一些工具对目前普遍存在的盗版现象进行了分析，指出盗版现象之所以大量存在，有其深刻的社会根源和经济原因，而盗版现象的猖獗泛滥会给全社会带来危害，我们的政府应在打击盗版活动中起主导作用。

关键词：盗版外部性经济学分析 piracy externalization economic analysis

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