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Metastatic hepatocellular carcinoma of the external auditory canal

World Journal of Gastroenterology 2007年第47期13卷 6436-6438页

作者： Ryuji Yasumatsu Kenji Okura Yumiko Sakiyama Makoto Nakamuta Taisei Matsumura Satoru Uehara Tomoya Yamamoto Shizuo Komune Department of Otorhinolaryngology Graduate School of Medical SciencesKyushu University and Department of Otorhinolaryngology and Clinical Research InstituteNational Hospital Organization Kyushu Medical CenterFukuoka 812-8582Japan Department of Otorhino-laryngology and Clinical Research Institute National Hospital Organization Kyushu Medical CenterFukuoka 812-8582Japan Department of Gastro-enterology and Clinical Research Institute National Hospital Organization Kyushu Medical CenterFukuoka 812-8582Japan Department of Radiology and Clinical Research Institute National Hospital Organization Kyushu Medical CenterFukuoka 812-8582Japan Department of Otorhinolaryngology Graduate School of Medical SciencesKyushu UniversityJapan

This report describes a rare case of metastatic hepatocellular carcinoma (HCC) presenting a huge mass in the left external auditory canal (EAC). The patient was a 55-year-old man with hepatitis B virus-related HCC. He presented to our department with a three-month history of increasing left otalgia,and hearing loss with recent fresh aural bleeding. Histopathologic examination indicated that the tumor was secondary to HCC. Although external irradiation was not effective,the tumor was treated with surgical debulking and high dose rate 192 Ir remote afterloading system (RALS) for postoperative intracavitary irradiation. A review of the literature revealed only five other cases of HCC metastasis to the temporal bone,all of which mainly metastasized in the internal acoustic meatus. The present case is the first report of HCC metastasis to the EAC.

关键词： Hepatocellular carcinoma Metastasis external auditory canal

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Middle ear foreign body causing cholesteatoma and external auditory canal granuloma: a case report

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Journal of Otology 2012年第1期7卷 25-27页

作者： ZHOU Shui-Hong WANG Qin-Ying WANG Shen-Qing Department of Otolaryngology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang310003China

Objective Patients with unilateral ear discharge and hearing loss often have external or middle ear diseases. We present a 55-year-old man who suffered from persistent ear discharge and hearing loss in the left ear. Local findings showed that his left ear canal was filled with a large amount of granulation tissue, with purulent, foul-smelling discharge. Computed tomography indicated left middle ear cholesteatoma and mass shadow in the left external auditory canal. Modified radical mastoidectomy was performed. A piece of white plastic stick was found in the middle ear during the operation. Foreign body-induced cholesteatoma and external auditory canal granuloma in adults are very rare. We present this rare case so that these conditions can be better recognized and understood.

关键词： foreign body cholesteatoma external auditory canal middle ear

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Metastasizing pleomorphic adenoma to the external auditory canal :a case report

Metastasizing pleomorphic adenoma to the external auditory c...

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2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学会口腔颌面-头颈肿瘤专业委员会学术年会——创新超越、共赢未来

作者： Sisi Li Kunming Zhao Yuexiao Li Changfu Sun Xuexin Tan School of Stomatology-China Medical University

Purpose/Background:Pleomorphic adenoma(PA)is up until now the most common tumor of parotid gland in the oral and maxillofacial region which mainly comes from Parotid epithelium. It was reported that PA of the external auditory canal is uncommon. However,in uncommon occasions the tumor can cover both parotid gland and external auditory canal

关键词： Pleomorphic adenoma Parotid gland external auditory canal Metastasize

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Pleomorphic Adenoma of the external auditory canal and Parotid Gland : Recurrence of an external auditory canal

Pleomorphic Adenoma of the External Auditory Canal and Parot...

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2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展

作者：李思思谭学新中国医科大学附属口腔医院

Pleomorphic adenoma(PA) is up until now the most common tumor of Parotid gland in the oral and maxillofacial region which mainly comes from Parotid epithelium. It was reported that PA of the external auditory canal is uncommon. However,in uncommon occasions the tumor can cover both Parotid gland and external auditory *** we are reporting a case which the tumor metastasized from external auditory canal(EAC)to parotid gland and was removed by en bloc resection of parotid gland and the tragus by surgical *** is essential of long-term follow *** is because the PA occurs in both Parotid gland and external auditory canal is rare and PA has the potential for malignant transformation.

关键词： Pleomorphicadenoma Parotidgland external auditory canal Metastasize

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Three cases of uncommon medication-associated osteonecrosis of temporal bone

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世界耳鼻咽喉头颈外科杂志英文版 2024年第03期10卷 237-240页

作者： VanDolah Hunter Crossley Jason R. Jeffrey Kim H. Georgetown University School of Medicine Washington DC USA Department of Otolaryngology–Head and Neck Surgery MedStar Georgetown University Hospital Washington DC USA

Introduction: Medication-related osteonecrosis of the temporal bone is rare and has been reported to be associated with the use of anti-resorptive and biologic agents. Here, we present the first case of tyrosine-kinase inhibitor-related external auditory canal (EAC) osteonecrosis as well as two cases related to anti-resorptive ***: A retrospective case ***: Case one: an 84-year-old female presented with chronic otitis externa and osteonecrosis of EACs bilaterally. She had a history of osteoporosis treated with denosumab and risedronic acid. She successfully underwent left EAC reconstruction using an inferiorly-based pedicle periosteal flap while the right ear canal was managed conservatively. Case two: a 69-year-old male presented with osteonecrosis of the right EAC. He had a history of osteoporosis treated with alendronic acid and zoledronic acid. His osteonecrosis is conservatively managed with local debridement and antibiotic application. Case three: a 60-year-old male presented with osteonecrosis of the right inferior EAC. He had a history of chronic myelogenous leukemia treated with a tyrosine-kinase inhibitor, imatinib. After failing conservative therapy, he underwent right ear canal reconstruction using a periosteal vascular pedicle flap without complication and experienced complete resolution to his ***: Anti-resorptive agents and/or tyrosine kinase inhibitors may lead to dysregulation of bone remodeling and result in rare cases of temporal bone osteonecrosis. When a local debridement and antibiotic therapy fail, definitive surgical excision of necrotic bone with subsequent reconstruction of the EAC may offer patients a possible resolution in symptoms.

关键词： bisphosphonates denosumab external auditory canal imatinib medication-related osteonecrosis osteonecrosis temporal bone tyrosine-kinase Inhibitors

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EXPERIENCE WITH OVERLAY TYMPANOPLASTY IN 83 CHINESE PATIENTS

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Journal of Otology 2014年第1期9卷 43-47页

作者： PENG Bengang MIAO Xutao WANG Xin ZHU Sixiang SUN Yiqing Department of Otolaryngology Jishuitan Hospital

Background In many European and American hospitals, represented by the House Ear Clinic (HEC), the overlay tympanoplasty is used with rare exception, with simultaneous canal wall up or down mastoidectomy being taken if needed. In China, underlay tympanoplasty is used across the country, but the overlay tech-nique is used rarely. The aim of the current study was to report the authors’experience with overlay tympa-noplasty in 83 Chinese patients and study its value. Methods Eight-three patients (86 ears) underwent over-lay tympanoplasty in accordance to the standard of the HEC. The patients were followed up and conditions of the external auditory canal, tympanic membrane and hearing were reviewed and analyzed. Results All patients gained stage I incision healing. The size of external auditory canal and tympanic membrane mor-phology were satisfactory. Hearing either remained unchanged or improved. There were no hearing deterio-ration or serious complications. Conclusions Overlay tympanoplasty carries positive value in treating chron-ic otitis media and cholesteatoma with the merits of procedure standardization, adequate operative exposure, thorough disease elimination and extensive adaptation.

关键词： Tympanoplasty Overlay technique external auditory canal Surgery

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