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Mechanism of Mingjing Granules in Treating Wet Age-Related Macular Degeneration Based on Network Pharmacology and experimental verification

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 22-32页

作者： Xiao-Yu Li Li-Na Liang Wei-Jun Zhang Yun Gao Qiang Chen Eye Function Laboratory Eye HospitalChina Academy of Chinese Medical SciencesBeijingChina China Evidence-Based Medicine Center for Traditional Chinese Medicine BeijingChina Center for East-West Medicine UCLA David Geffen School of MedicineLos AngelesCAUSA

Objective:To analyze the potential mechanism of Mingjing granules in the treatment of wet age-related macular degeneration(wAMD)based on the research methods of network pharmacology and molecular docking approach and to provide a new reference for the currently limited treatment of wAMD.Materials and Methods:We searched TCMSP,GeneCards,OMIM,PharmGkb,TTD,and DrugBank database to screen the main active ingredients of Mingjing granules and their therapeutic targets of wAMD.The network of active components and targets was constructed using Cytoscape3.6.1 software,which was also used for the topological analysis of target genes.The network of Protein-Protein Interactions(PPI)was mapped using the String platform.We also used R language to do the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway for additional analysis.Molecular docking studies were finished by Chemoffice,Autodock,and Pymol.Finally,the efficacy of the Mingjing granules was examined in animal experiments,in which we used enzyme-linked immunosorbent assay to the contents of vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)levels in peripheral blood.Results:Active compounds,including quercetin,lignocaine,and kaempferol,were found.PPI network analysis showed that tumor necrosis factor(TNF),MMP-9,epidermal growth factor(EGF),prostaglandin-endoperoxide synthase 2(PTGS2),and caspase-3(CASP3)were related to both Mingjing granules and wAMD.GO and KEGG pathway analysis showed that these targets were mainly involving lipids and atherosclerosis,TNF,and interleukin-17(IL-17)signaling pathways.Docking studies suggested that quercetin and luteolin can fit in the binding pocket of four target proteins(CASP3,EGF,PTGS2,and TNF).In the vivo experiment,the Mingjing granules were found to be effective on the expression of VEGF and MMP-9 in peripheral blood.Conclusions:This study initially reveals the multi-constituent,multi-target,and multi-pathway mechanism of action of Mingjing granules in the treatment of wAMD and impli

关键词： experimental verification Mingjing granules molecular docking network pharmacology wet age-related macular degeneration

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Efficacy of Juanbi capsule on ameliorating knee osteoarthritis:a network pharmacology and experimental verification-based study

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Traditional Medicine Research 2024年第6期9卷 19-30页

作者： Wen-Bo Huang Shu-Ya Qin Jun-Bo Zou Xun Li Wu-Lin Kang Pu-Wei Yuan The First Clinical Medical College of Shaanxi University of Chinese Medicine Xianyang 712046China College of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Department of Orthopedic Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712099China

Background:The purpose of the study was to investigate the active ingredients and potential biochemical mechanisms of Juanbi capsule in knee osteoarthritis based on network pharmacology,molecular docking and animal experiments.Methods:Chemical components for each drug in the Juanbi capsule were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,while the target proteins for knee osteoarthritis were retrieved from the Drugbank,GeneCards,and OMIM databases.The study compared information on knee osteoarthritis and the targets of drugs to identify common elements.The data was imported into the STRING platform to generate a protein-protein interaction network diagram.Subsequently,a“component-target”network diagram was created using the screened drug components and target information with Cytoscape software.Common targets were imported into Metascape for GO function and KEGG pathway enrichment analysis.AutoDockTools was utilized to predict the molecular docking of the primary chemical components and core targets.Ultimately,the key targets were validated through animal experiments.Results:Juanbi capsule ameliorated Knee osteoarthritis mainly by affecting tumor necrosis factor,interleukin1β,MMP9,PTGS2,VEGFA,TP53,and other cytokines through quercetin,kaempferol,andβ-sitosterol.The drug also influenced the AGE-RAGE,interleukin-17,tumor necrosis factor,Relaxin,and NF-κB signaling pathways.The network pharmacology analysis results were further validated in animal experiments.The results indicated that Juanbi capsule could decrease the levels of tumor necrosis factor-αand interleukin-1βin the serum and synovial fluid of knee osteoarthritis rats and also down-regulate the expression levels of MMP9 and PTGS2 proteins in the articular cartilage.Conclusion:Juanbi capsule may improve the knee bone microstructure and reduce the expression of inflammatory factors of knee osteoarthritis via multiple targets and multiple signaling pathways.

关键词： osteoarthritis inflammation MMP9/PTGS2 network pharmacology Juanbi capsule experimental verification

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Refined modeling and experimental verification of a torque motor for an electro-hydraulic servo valve

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Chinese Journal of Aeronautics 2023年第6期36卷 302-317页

作者： Zhichuang CHEN Shenghong GE Yulei JIANG Wenhao CHENG Yuchuan ZHU National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China Aviation Key Laboratory of Science and Technology on Aero Electromechanical System Integration Nanjing Engineering Institute of Aircraft SystemsNanjing 210061China AVIC Nanjing Servo Control System Co. LtdNanjing 210032China

The Permanent Magnet Torque Motor(PMTM)is the key electro-mechanical conversion device in an Electro-Hydraulic Servo Valve(EHSV).In this work,a refined model of a PMTM is developed,considering the non-working air-gaps between the upper or lower yoke and the armature,the fringing effect at the limiting holes,and the nonlinear permeability of soft magnetic material.Based on the refined model,the influences of various factors on the calculation accuracy of the magnetic flux at the pole surfaces of the armature and the output torque are investigated.For verifying the validity of the refined model,a Finite Element Analysis(FEA)of the PMTM is conducted,and a test platform is constructed.Compared with existing models,the refined model can better reveal the intrinsic mechanism of the PMTM,and its calculations are more consistent with the FEA results.The experimental results of the armature deflection displacement show that the refined model can accurately describe the output characteristics of the PMTM.

关键词： Calculation accuracy Electro-hydraulic servo valve experimental verification Finite element analysis Refined model Torque motor

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Optimal Design and experimental verification of Low Radiation Noise of Gearbox

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Chinese Journal of Mechanical Engineering 2022年第6期35卷 123-135页

作者： Lan Liu Kun Kang Yingjie Xi Zhengxi Hu Jingyi Gong Geng Liu Shaanxi Engineering Laboratory for Transmissions and Controls School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Xi’an Aerospace Dynamic Test Technology Research Institute Xi’an 710072China

Reducing the radiated noise of a gearbox is a difficult problem in aviation,navigation,machinery,and other fields.Structural improvement is the main means of noise reduction for a gearbox,and it is realized primarily through contribution analysis and structure optimization.However,these approaches have certain limitations.In this study,a low-noise design method for a gearbox that combines the two approaches is proposed,and experimental verification is performed.First,a finite element/boundary element model is established using a single-stage herringbone gearbox.Considering the vibration excitation of the gear system,the radiation noise of a single-stage gearbox is predicted based on the modal acoustic transfer vector(MATV)method.Subsequently,the maximum field point of the radiated noise is determined,and the acoustic transfer vector(ATV)analysis and modal acoustic contribution(MAC)analysis are conducted to determine the region that contributes significantly to the radiated noise of the field point.The optimization region is selected through the panel acoustic contribution(PAC)analysis.Next,to reduce the normal speed in the optimization region,topology optimization is performed.According to the topology optimization results,four different noise reduction structures are added to the gearbox,and the low-noise optimization models are established respectively.Finally,by measuring the radiated noise of the gearbox before and after optimization under a given working condition,the validity of the radiated noise prediction method and the low-noise optimization design method are verified by comparing the simulation and experimental data.A comparison of the four optimization models proves that the noise reduction effect can be achieved only by adding a noise reduction structure to the center of the density nephogram.

关键词： Radiated noise prediction Acoustic contribution analysis Topology optimization Noise reduction structures experimental verification

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Integrated network pharmacology and experimental verification to explore the mechanism of Sangqi Qingxuan formula against hypertensive vascular remodeling

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Journal of Traditional Chinese Medical Sciences 2022年第3期9卷 277-288页

作者： Lingling Li Jiayun Wu Ruiqi Yao Deshuang Yang Ying Chen Jin Zhang Li Huang School of Postgraduate Beijing University of Chinese MedicineBeijing102488China Department of Cardiology Beijing University of Chinese Medicine Shenzhen Hospital(Longgang)Shenzhen518172China Department of Integrative Cardiology China-Japan Friendship HospitalBeijing100029China

Objective: To investigate the bioactive components of Sangqi Qingxuan formula(SQQX), predict the pharmacological targets, and explore the mechanism of hypertensive vascular remodeling(HVR).Methods: Network pharmacology was adopted to predict how SQQX acts in HVR. The effectiveness was assessed by blood pressure measurements and pathological morphology observation based on a spontaneously hypertensive rat model, while the mechanism of SQQX on HVR was validated by immunohistochemistry(IHC) and western blot(WB) according to the results of network pharmacology.Results: There were 130 bioactive components of SQQX and 231 drug targets predicted by the Traditional Chinese Medicine Systems Pharmacology Database. Subsequently, 181 common targets were identified for SQQX against HVR, with TP53, MAPK1, and AKT1 as the core targets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses was employed to identify the top 20 enriched functions and the top 20 pathways(P <.01). Finally, the key role of the ERK/MAPK signaling pathway in HVR was determined. The in vivo results suggested that SQQX reduced systolic blood pressure and increased the ratio of thoracic aortic wall thickness to lumen diameter. Additionally, compared with the model group, SQQX increased the expression of smooth muscle 22 alpha(IHC: P <.001;WB:P <.05) and decreased the expression of osteopontin(IHC: P <.001;WB: P <.05), ERK1/2(IHC: P <.001;WB: ERK1 & ERK2, all P <.05), p-ERK1/2(IHC: P <.001;WB: ERK1 & ERK2, all P <.05), and the ratio of pERK1/2 to ERK1/2 protein(IHC: P <.001).Conclusions: SQQX, which has multiple bioactive ingredients and potential targets, is an effective treatment for HVR. The mechanism of antihypertensive and vascular protection may be related to the inhibition of phenotypic transformation of vascular smooth muscle cells and the ERK/MAPK signaling pathway.

关键词： Sangqi Qingxuan formula Network pharmacology Hypertensive vascular remodeling Action mechanism experimental verification Spontaneously hypertensive rats Phenotypic transformation ERK/MAPK pathway

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Numerical simulation and experimental verification of plasma jet development in gas gap switch

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Plasma Science and Technology 2023年第5期25卷 159-169页

作者：董冰冰郭志远张泽霖文韬向念文 Hefei University of Technology Hefei 230009People’s Republic of China

Plasma jet triggered gas gap switch has obvious advantages in fast control switch.The development of the plasma in the ambient medium is the key factor affecting the triggering conduction of the gas switch.However,the plasma jet process and its characteristic parameters are complicated and the existing test methods cannot fully characterize its development laws.In this work,a two-dimensional transient fluid calculation model of the plasma jet process of the gas gap switch is established based on the renormalization-group k-εturbulence equation.The results show that the characteristic parameters and morphological evolution of the plasma jet are basically consistent with the experimental results,which verifies the accuracy of the simulation model calculation.The plasma jet is a long strip with an initial velocity of 1.0 km·s-1and develops in both axial and radial directions.The jet velocity fluctuates significantly with axial height.As the plasma jet enters the main gap,the pressure inside the trigger cavity drops by80%,resulting in a rapid drop in the jet velocity.When the plasma jet head interacts with the atmosphere,the two-phase fluid compresses each other,generating a forward-propelled pressure wave.The plasma jet heads flow at high velocity,a negative pressure zone is formed in the middle part of the jet,and the pressure peak decreases gradually with height.As the value of the inlet pressure increases,the characteristic parameters of the plasma jet increase.The entrainment phenomenon is evident,which leads to an increase in the pressure imbalance of the atmospheric gas medium,leading to a significant Coanda effect.Compared with air,the characteristic parameters of a plasma jet in SF6are lower,and the morphological evolution is significantly suppressed.The results of this study can provide some insight into the mechanism of action of the switch jet plasma development process.

关键词： gas gap switch plasma jet k-εturbulence model numerical calculation experimental verification

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Efficacy of Lushi Runzao decoction(路氏润燥汤)on ameliorating Sjogren's syndrome:a network pharmacology and experimental verification-based study

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中医杂志:英文版 2023年第4期43卷 751-759页

作者： PANG Fengtao LI Kesong ZHANG Yi TANG Xiaopo ZHOU Xinyao Department of Rheumatology Guang’anmen HospitalChinese Academy of Chinese Medical SciencesBeijing 100053China

OBJECTIVE:To investigate the possible mechanism underlying the effect of the Lushi Runzao decoction(路氏润燥汤)on Sjogren's syndrome using network pharmacology and to verify the mechanisms via animal experiments.METHODS:Available biological data on each drug in the Lushi Runzao decoction were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,and the target proteins of Sjogren's syndrome were retrieved from the GeneCards database.Information regarding Sjogren's syndrome and the targets of the drugs were compared to obtain overlapping elements.This information was imported into the STRING platform to obtain a proteinprotein interaction network diagram,following which a“component-target”network diagram was constructed using screened drug components and target information via Cytoscape software.The database for annotation,visualization,and integrated discovery was used for Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathways analyses.Pathway information predicted by network pharmacology was verified using animal experiments.RESULTS:The Lushi Runzao decoction ameliorated Sjogren's syndrome mainly by influencing tumor necrosis factor as well as certain cytokines and chemokines.The decoction also influenced the interleukin-17 and advanced glycosylation end products(AGE)-receptor for AGE signaling pathways.CONCLUSION:The Lushi Runzao decoction ameliorates Sjogren's syndrome via multiple targets and multiple signaling pathways.Network pharmacology is useful for making a comprehensive prediction regarding the efficacy of the Lushi Runzao decoction,and this information may be helpful in clinical research.

关键词： immune system diseases tumor necrosis factors network pharmacology Lushi Runzao decoction experimental verification

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Nonlinear response analysis and experimental verification for thin-walled plates to thermal-acoustic loads

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Chinese Journal of Aeronautics 2017年第6期30卷 1919-1930页

作者： Yundong SHA Jian WANG Liaoning Key Laboratory of Advanced Test Technology for Aeronautical Propulsion System Shenyang Aerospace University Shenyang 110136 China

For large deflection strongly nonlinear response problem of thin-walled structure to thermal-acoustic load, thermal-acoustic excitation test and corresponding simulation analysis for clamped metallic thin-walled plate have been implemented. Comparing calculated values with experimental values shows the consistency and verifies the effectiveness of calculation method and model for thin-walled plate subjected to thermal-acoustic load. Then this paper further completes dynamic response calculation for the cross reinforcement plate under different thermalacoustic load combinations. Based on the obtained time-domain displacement response, analyses about structure vibration forms are mainly focused on three typical motions of post-buckled plate,indicating that the relative strength between thermal load and acoustic load determines jump forms of plate. The Probability spectrum Density Functions（PDF） of displacement response were drawn and analyzed by employing statistical analysis method, and it clearly shows that the PDF of postbuckled plate exhibits bimodal phenomena. Then the Power Spectral Density（PSD） functions were used to analyze variations of response frequencies and corresponding peaks with the increase of temperatures, as well as how softening and hardening areas of the plate are determined. In the last section, this paper discusses the change laws of tensile stress and compressive stress in pre/post buckling areas, and gives the reasons for N glyph trend of the stress Root Mean Square（RMS）.

关键词： Buckling experimental verification Nonlinear response Power spectral density Probability spectrum densitySnap-through Thermal-acoustic load Thin-walled structure

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Cable-driven legged landing gear for unmanned helicopter:Prototype design,optimization and performance assessment

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Science China(Technological Sciences) 2024年第4期67卷 1196-1214页

作者： TIAN BaoLin GAO HaiBo YU HaiTao SHAN HaoMin HOU JunChen YU HongYing DENG ZongQuan State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China China Academy of Aerospace Science and Innovation Beijing 100048China

Unmanned helicopters equipped with adaptive landing gear will dramatically extend their application especially in dealing with challenging terrains.This study presents a novel cable-driven legged landing gear(CLG)with differential transmission for unmanned helicopters in complex landing environments.To obtain the preferred configuration of the legged mechanism,a multi-objective optimization framework for the CLG is constructed by concurrently considering terrain adaptability,landing stability and reasonable linkage of internal forces.The non-dominated sorting genetic algorithmⅡis employed to numerically acquire the optimal scale parameters that guide the mechanical design of the CLG.An unmanned helicopter prototype equipped with the devised CLG is developed with key performance assessment.experimental results show that the devised CLG can provide energy-efficient support over uneven terrains(totally driven torque demand less than 0.1 N m)in quasi-static landing tests,and favorable terrain adaptability(posture fluctuation of the fuselage less than±1°)in unknown slope landing tests.These exhibited merits give the proposed CLG the potential to enhance the landing performance of future aircraft in extreme environments.

关键词： unmanned helicopter adaptive landing gear experimental verification

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Investigation of anisotropic strength criteria for layered rock mass

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1289-1304页

作者： Shuling Huang Jinxin Zhang Xiuli Ding Chuanqing Zhang Gang Han Guoqi Yu Lulu Qu Key Laboratory of Geotechnical Mechanics and Engineering of the Ministry of Water Resources Changjiang River Scientific Research InstituteWuhan430071China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430000China University of Chinese Academy of Sciences Beijing100049China

Layered rock mass is a type of engineering rock mass with sound mechanical anisotropy,which is generally unfavorable to the stability of underground works.To investigate the strength anisotropy of layered rock,the Mohr-Coulomb and Hoek-Brown criteria are introduced to establish the two transverse isotropic strength criteria based on Jaeger's single weak plane theory and maximum axial strain theory,and parameter determination methods.Furthermore,the sensitivity of strength parameters(K 1,K 2,and K 3)that are used to characterize the anisotropy strength of non-sliding failure involved in the strength criteria and confining pressure are investigated.The results demonstrate that strength parameters K 1 and K 2 affect the strength of layered rock samples at all bedding angles except for the bedding angle of 90°and the angle range that can cause the shear sliding failure along the bedding plane.The strength of samples at any bedding angle decreases with increasing K 1,whereas the opposite is for K 2.Except for bedding angles of 0°and 90°and the bedding angle range that can cause the shear sliding along the bedding plane,K 3 has an impact on the strength of rock samples with other bedding angles that the specimens'strength increases with increase of K 3.In addition,the strength of the rock sample increases as confining pressure rises.Furthermore,the uniaxial and triaxial tests of chlorite schist samples were carried out to verify and evaluate the strength criteria proposed in the paper.It shows that the predicted strength is in good agreement with the experimental results.To test the applicability of the strength criterion,the strength data of several types of rock in the literature are compared.Finally,a comparison is made between the fitting effects of the two strength criteria and other available criteria for layered rocks.

关键词： Layered rock Strength anisotropy Strength criterion experimental verification

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