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Expressions of cellular retinoic acid binding proteins I and retinoic acid receptor-β in the guinea pig eyes with experimental myopia

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International Journal of Ophthalmology(English edition) 2011年第2期4卷 131-136页

作者： Jia Huang Xiao-Mei Qu and Ren-Yuan Chu Department of Ophthalmology Eye and ENT Hospital Affiliated to Fudan University Shanghai 200031 China

OBJECTIVE:All-trans retinoic acid (RA) is the only extrinsic biochemical candidate known to date that could act as a growth controller, the aim of this study was to investigate the expression cellular retinoic acid binding proteins I (CRABP-I) and retinoic acid receptor-β (RAR-β) in retina of the guinea pig eyes with experimental myopia.;METHODS:Ninety guinea pigs aged 14 days were equally and randomly divided into three groups: form deprivation (FD), -5D lens, and control. The diffusers for FD were white translucent hemispheres, and -5D lenses were used to introduce hyperopic defocus. Refraction was measured with streak retinoscopy after cycloplegia, and axial length was calculated with Cinescan A/B ultrasonography. Retina harvested at different time points were used to measure RA level with HPLC and expressions of cellular retinoic acid binding proteins I (CRABP-I) and RA receptor-β (RAR-β) were assayed with Western blot and Real-time PCR. SPSS13.0 software was used for statistical analysis.;RESULTS:Up-regulations of CRABP-I and RAR-β in ocular tissues correlated with changes in the refractive status and growth rate of the guinea pig eye (Pmyopia and a 0.281mm axial elongation; 14 days of monocular defocus produced -3.64D myopia and a 0.163 mm axial elongation. The level of retinal RA started to elevate in 7 days (Pexperimental myopia. During the progression of experimental myopia, the retinal RA level increased rapidly, and there might be a positive feedback between the

关键词： retinoic acid CRABP-I RAR-β experimental myopia guinea pig

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Complement factors C1q, C3 and C5b-9 in the posterior sclera of guinea pigs with negative lens-defocused myopia

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 675-680页

作者： Ting-Ting Gao Qin Long Xue Yang Department of Ophthalmology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

· AIM: To investigate the expression of complement factors in the posterior scleral fibroblasts of guinea pigs with negative lens-defocused myopia.· METHODS: Eighteen guinea pigs were assigned randomly to two groups: the negative lens-defocused group(NLD group, n =9) and the normal control without treatment group(NC group, n =9). The effect of myopic induction was compared in three subgroups: eyes treated with a-10.00 D negative lens in the NLD group(NL group), eyes treated with a plano(0 D) lens in the NLD group(PL group), and untreated right eyes in the NC group(NC group). The following analyses were conducted at four weeks: examination of the refractive error via retinoscopy, assessment of complement C5b-9expression in the posterior scleral fibroblasts using immunohistochemistry, and measurements of complement C1 q and C3 protein levels in the posterior sclera by Western blot.·RESULTS: After an induction period of four weeks, a significant myopic shift was detected in the eyes of the NL group, relative to that of the PL and NC groups(P myopia.

关键词： experimental myopia complement factors sclera inflammation

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The Retinal and Central Mechanism of Primates myopia

The Retinal and Central Mechanism of Primates Myopia

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The Third Asian Conference on Vision (ACV2004)

作者： Ge Jian Zhong Xingwu Wu JunshuZhongshan Ophthalmic Center Guangzhou China Postalcode: 510060

＜正＞ The process of retractive status development in primates such as rhesus monkeys is very similar to that in human beings. Moreover, the period from birth to 3 years old of age in rhesus monkeys is assumably comparative to that from birth to 12 years old of age in human beings. The alteration of vision conditions such as optical defocus or form deprivation can remarkably affect the emmetropization process which provides a most ideal model for

关键词： experimental myopia rhesus monkey visual cortex optical defocus form deprivation

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