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A Comparison Study of the Efficacy of Rapid Titration Quetiapine and Haloperidol in Agitated Adults in an Emergency Setting

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Open Journal of Psychiatry 2014年第3期4卷 189-194页

作者： Akikur Mohammad Eugene Laska Marius Campaneau Fauzia Syed Rebecca Ninah Joseph Wanderling George Simpson Department of Psychiatry LAC-USC Los Angeles CA USA Nathan Kline Institute New York NY USA

Objective: Intramuscular (IM) Benzodiazepines and/or Haloperidol alone or with benzodiazepines are frequently used to treat agitation. Based on emerging literature regarding Quetiapine used for the control of anxiety we examined Quetiapine as a possible alternative in selected cases. Methods: This study was a single-blind randomized study comparing Quetiapine PO (300 mg) with a combination of Haloperidol (5 mg), Benztropine mesylate (2 mg) and lorazepam (2 mg) administered IM to treat agitated patients seeking care in a busy psychiatric emergency setting. Male or female patients (18 - 60), deemed by the attending (admitting) psychiatrist to be indicative of agitated and/or aggressive behavior and had a Positive and Negative Syndrome Score-Excited Component (PANSS-EC), as evaluated by the Research Psychiatrist, and total score equal to or greater than 15. Patients deemed competent were randomized into one of the following treatment groups: Quetiapine 300 or Haloperidol 5 mg, benztropine mesylate, or lorazepam given by the IM route. Two scales, PANSS-EC and CGI-C were used to assess patients in the trial. The primary outcome measure PANSS-EC at 2 hours after administration of the medication. Results: Sixty-eight patients were included in the study. There were no significant treatment group differences in baseline condition. There was no significant difference between the two conditions. There was, however, a significant within-group decrease from baseline condition. Conclusion: Finding no significant differences suggests that in general the two treatments were equivalent. To sum up, Quetiapine 300 mg as a single dose appeared safe and effective in agitated patients treated in an ER. The results were similar to a comparison group receiving an intra-muscular combination of Haloperidol, Lorazepam and Benztropine. This study has significant limitations. The study was single blind and the use of a placebo would have strengthened the design but would be considered unethical

关键词： Quetiapine (Oral) Haloperidol (Parenteral) Agitation excitement Psychoses

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Erogenous Zones: Described in Old Sanskrit Literature

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Advances in Sexual Medicine 2014年第2期4卷 25-28页

作者： R. Nambisan K. P. Skandhan Department of Physiology Sree Narayana Institute of Medical Sciences Chalakka India Senior Medical Officer Government Ayurveda Hospital Ponnani India

Our knowledge on erogenous points in both male and female is limited. We present here the vast knowledge on the same availability which existed in India during the 13th century.

关键词： Erogenous Zones Moon Influence Lunar Month Synodic Month Sexual excitement Sexual Pleasure

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莎士比亚与英语词汇(32)

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英语知识 2005年第8期 22-23页

作者：杨俊峰大连外国语学院

该词的意思是“兴奋，激动；激励；激发热情”。英语的释义是act of arousing；stimulation；enthusiasm。

关键词：莎士比亚英语词汇 excitement exposure 用法词义例句

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Language Environment Setting Through Our Foreign Currency Activities to Improve Chinese-Majoring Learners’ Competency

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Sino-US English Teaching 2019年第2期16卷 64-74页

作者： Mai Thi Ngoc Anh Thai Nguyen University Thai Nguyen ProvinceVietnam

Language education centers primarily on fostering linguistic skills and language communication skills for students. In the process of teaching Chinese language, it is in the classroom that is the place tofoster student’s linguistic competence and language communication capacity. Therefore, classroom teaching becomes the main place tofoster the language ability and language communication capacity for students while the extracurricular activities are the place for students to apply the knowledge they have learned in the classroom in to the real world. Conducting a survey to investigate extracurricular activities for Chinese language majors at Thai Nguyen University, School of Foreign Languages, the paper proposes solutions to improve the effectiveness of extracurricular activities for students and create excitement for students in learning.

关键词： setting language learning environment efficiency excitement extracurricular activities Chinese

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