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Carbon Nanotube Transistor with Short-Term Memory

Tsinghua Science and Technology 2016年第4期21卷 442-448页

作者： Changqing Yin Yuxing Li Jiabin Wang Xuefeng Wang Yi Yang Tian-Ling Ren Institute of Microelectronics Tsinghua University Institute of Microelectronics and Tsinghua National Laboratory for Information Science and Technology Tsinghua University

Short-Term Memory （STM） is a primary capability of the human brain. Humans use STM to remember a small amount of information, like someone＇s phone number, for a short period of time. Usually the duration of STM is less than 1 minute. Synapses, the connections between neurons, are of vital importance to memory in biological brains. For mimicking the memory function of synapses, Carbon Nanotube （CNT） networks based thin- film transistors with Electric Double Layers （EDL） at the dielectric/channel interface were researched in this work. A response characteristic of pre-synaptic potential pulses on the gate electrode of this CNT synaptic transistor was shown remarkably similar to excitatory Post-Synaptic current （EPSC） of biological synapses. Also a multi-level modulatable STM of CNT synaptic transistors was investigated. Post-synaptic current was shown with tunable peak values, on-off ratio, and relaxation time.

关键词： carbon nanotube thin-film transistor synapse excitatory postsynaptic current short-term memory

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Changes in synaptic and extrasynaptic N-methyl-D-aspartate receptor-mediated currents at early-stage epileptogenesis in adult mice

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Neural Regeneration Research 2011年第2期6卷 118-124页

作者： Juegang Ju Sheng-tian Li Laboratory of Synaptic Signaling and Behavioral Neurosciences School of Life Science and Biotechnology Shanghai Jiao Tong UniversityShanghai 200240 China

Previous reports have shown that N-methyl-D-aspartate （NMDA） receptors are extensively involved in epilepsy genesis and recurrence. Recent studies have shown that synaptic and extrasynaptic NMDA receptors play different, or even opposing, roles in various signaling pathways, including synaptic plasticity and neuronal death. The present study analyzed changes in synaptic and extrasynaptic NMDA receptor-mediated currents during epilepsy onset. Mouse models of lithium chloride pilocarpLne-induced epilepsy were established, and hippocampal slices were prepared at 24 hours after the onset of status epilepticus. Synaptic and extrasynaptic NMDA receptor-mediated excitatory post-synaptic currents （NMDA-EPSCs） were recorded in CA1 pyramidal neurons by whole-cell patch clamp technique. Results demonstrated no significant difference in rise and delay time of synaptic NMDA-EPSCs compared with normal neurons. Peak amplitude, area-to-peak ratio, and rising time of extrasynaptic NMDA-EPSCs remained unchanged, but decay of extrasynaptic NMDA-EPSCs was faster than that of normal neurons, These results suggest that extrasynaptic NMDA receptors play a role in epileptogenesis.

关键词： N-methyl-D-aspartate receptor excitatory postsynaptic current epilepsy epileptogenesis hippocampus

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