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Experience-dependent maturation of intracortical parvalbumin expressing-cell circuit in developing mouse visual cortex

Experience-dependent maturation of intracortical parvalbumin...

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中国神经科学学会第十届全国学术会议

作者： Qing-Long MIAO Xiao-Hui ZHANG Laboratory of Neuronal Processing & Plasticity Institute of Neuroscience and State Key Laboratory of NeuroscienceShanghai Institutes for Biological SciencesChinese Academy of Sciences

Critical period is a well-defined early developmental time window in which the brain is extremely sensitive to experience *** studies suggest that maturation of cortical GABAergic inhibition mediated by parvalbumin(PV)-cells is necessary for opening the critical ***,it remains elusive what detailed developmental changes in this particular inhibitory PV-cell circuit endorse its key regulation on the occurrence of the critical period of visual *** the present study,by performing dual whole-cell recordings of cortical neurons in acute brain slices,we systematically investigated the functional maturation of the cortical PV-cell synaptic circuits in layer 4,the main thalamorecipient lamina,of mouse visual cortex aged from eye opening(14) to critical-period onset(20).Our results showed a dramatic reduction in the short-term depression(STD) of PC to PV synapses along with unchanged synaptic strength during P14-20,but little change in the STD of reciprocal PV to PC synapses and a two-fold increase in its transmission *** contrast,the recurrent excitatory synapse between PCs in layer 4decreased its strength by 50%with little change in its ***,there was no developmental change in the strength and STD at the GABAergic and electrical connections between the PV cells,or the STD of thalamocortical synapses onto both layer 4 PCs and PV-cells during the same *** experiments with mice dark reared from birth indicated that these above differential synaptic changes in layer 4 recurrent circuits could be blocked by the deprivation of early visual *** together,the differential modifications of synaptic function in the cortical PV-cell circuit and recurrent excitatory network by experience lead to a preferential promotion of the intra-cortical inhibition over the excitation in developing visual cortex at the time of critical period onset,which endorsing the role of cortical PV-cell circuit in regulating the criti

关键词： critical period onset excitation/inhibition short-term plasticity parvalbumin-positive intemeuron

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