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Efficacy of 308-nm Monochromatic excimer lamp and Topical Tacrolimus Combination Therapy in Localized Vitiligo:A Study in Vietnam

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International Journal of Dermatology and Venereology 2023年第4期6卷 224-228页

作者： Hien Thi Thu Do Hao Thai Minh Nguyen Takuro Kanekura National Hospital of Dermatology and Venereology Hanoi 100000Vietnam Department of Dermatology Kagoshima University Graduate School of Medical and Dental SciencesKagoshima 890-8544Japan.

Objective:Combination therapy of a 308-nm monochromatic excimer lamp and topical tacrolimus is widely used in the treatment of localized vitiligo;however,there are no published studies investigating this combination therapy in Vietnamese patients with *** study was performed to evaluate the efficacy of combined excimer lamp and topical tacrolimus therapy for patients with localized vitiligo in ***:We performed a pre-post clinical trial of 30 patients diagnosed with localized vitiligo in *** patients were treated with an excimer lamp twice weekly and with topical tacrolimus twice *** was evaluated based on the reduction rate of the vitiligo area scoring index (VASI).Data were analyzed using descriptive statistics,Fisher’s exact test,Kruskal-WallisH test,and Spearman correlation coefficient ***:After 12 weeks of treatment,response was excellent or good in 16 patients (53.3%),moderate in 8 patients (26.7%),and poor in 6 patients (20.0%).The excellent or good responses increased over time from 3 patients (10.0%) at 6 weeks to 16 patients (53.3%) at 12 weeks (P = 0.001).Earlier initiation of repigmentation was associated with a better response to treatment (r = -0.71;P = 0.020).Patients with a perifollicular repigmentation pattern responded better to treatment than those with combined or marginal repigmentation patterns (P = 0.003).Side effects occurred in 13 patients (43.3%),including burning (43.3%),pruritus (10.0%),and mild blistering (6.7%),and none of these interrupted the ***:Combination therapy with excimer lamp and topical tacrolimus appears to be effective and safe in treating patients with localized vitiligo in Vietnam.

关键词： localized vitiligo excimer lamp topical tacrolimus

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Formation of High-quality Advanced High-k Oxide Layers at Low Temperature by excimer UV lamp-assisted Photo-CVD and Sol-gel Processing

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Chemical Research in Chinese Universities 2004年第4期20卷 396-402页

作者： YU J. J. Electronic & Electrical Engineering University College London

We have successfully demonstrated that high quality and high dielectric constant layers can be fabricated by low temperature photo-induced or -assisted processing. Ta_2O_5 and ZrO_2 have been deposited at texcimer lamps. The UV annealing of as-grown layers was found to significantly improve their electrical properties. Low leakage current densities on the order of 10 -8 A/cm 2 at 1 MV/cm for deposited ultrathin Ta_2O_5 films and ca.10 -6 A/cm 2 for the photo-CVD ZrO_2 layers and photo-irradiated sol-gel HfO_2 layers have been readily achieved. The improvement in the leakage properties of these layers is attributed to the UV-generated active oxygen species O( 1D) which strongly oxidize any suboxides to form more stoichiometric oxides on removing certain defects, oxygen vacancies and impurities present in the as-prepared layers. The photo-CVD Ta_2O_5 films deposited across 10.16-cm Si wafers exhibit a high thickness uniformity with a variation of less than \{±2.0%\} being obtained for ultrathin ca.10 nm thick films. The lamp technology can in principle be extended to larger area wafers, providing a promising low temperature route to the fabrication of a range of high quality thin films for future ULSI technology.

关键词： excimer lamp High-kdielectrics Thin film Chemical vapour deposition(CVD) Sol-gel processing

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