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Classification of Oxfordshire community stroke project assisted by transcranial Doppler ultrasound examination for treating acute cerebral infarction

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Neural Regeneration Research 2006年第5期1卷 441-444页

作者： Xiaohua Xiao Jie Situ Tinghui Li Shaohong Qiu Department of Internal Medicine Shenzhen Hospital of Prevention and Treatment for Occupational Disease （original Shenzhen Railway Hospital） Shenzhen 518001 Guangdong Province China

BACKGROUND： The early correct diagnosis of acute cerebral infarction （ACI） is very important for choosing therapeutic regimen. The classification of Oxfordshire community stroke project （OCSP） provides guide for easy and rapid diagnosis and choosing therapeutic regimen in clinical practice. But current operation is not satisfied. Only depending on clinical symptoms and body signs do objective evidences lack. Transcranial Doppler ultrasound （TCD） examination may provide hemodynamical evidences for the correct classification of OCSP to some extent. OBJECTIVE： To compare the results of OCSP classification and TCD examination for treating ACI in patients and analyze the relationship between them as well as the effect of TCD on the correct classification of OCSP. DESIGN ： Controlled observation.SETTING： Department of Internal Medicine, Shenzhen Hospital of Prevention and Treatment for Occupationa Disease. PARTICIPANTS： Thirty-eight inpatients with ACI including 21 males and 17 females, aged 50 to 81 years, who received treatment in the Department of Internal Medicine, Shenzhen Hospital of Prevention and Treatment for Occupational Disease within 24 hours after onset from October 2002 to October 2005 were involved. The involved inpatients all confirmed to the diagnostic criteria of ACI formulated in the 4^th National Cerebrovascular Diseases Conference. All the cases received skull computer tomography （CT） or magnetic resonance imaging （MRI） examinations at 24 hours after onset. Those patients who had no obvious infarct focus in skull CT examination within 24 hours after onset were performed re-examination to verify ACI within 72 hours after onset. Informed consents of examination method were obtained from all the patients. METHODS ： According to the classification of OCSP, the patients were assigned into 4 subtypes： lacunar infarction （LACI）, total anterior circulation infarction （TACI）, part anterior circulation infarction （PACI） and posterior circulation infar

关键词： acute cerebral infarction ultrasound examination blood flow velocity of Prevention and Treatment middle cerebral artery sequence of transcranial Doppler Occupational Disease magnetic resonance imaging diagnostic criteria computer tomography Doppler ultrasound current operation clinical practice reference value examination of diagnosis of

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自制口哨在老年患者肺功能检查中的应用

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中国实用护理杂志 2010年第8期26卷 56-57页

作者：陈露高莉梅齐娜李艳君苏红艳马惠娜刘聪聪河北大学附属医院呼吸科

肺功能检查对于呼吸道疾病患者,如支气管哮喘和慢性阻塞性肺部疾病等,有助于判断疾病期,作为临床诊断和鉴别诊断的依据,决定治疗方案,判断药物疗效,起着至关重要的作用。老年人受心理因素和生理因素的影响,如在肺功能检

关键词：口哨老年患者肺功能检查 examination of 慢性阻塞性肺部疾病诊断和鉴别诊断老年人支气管哮喘现报道如下治疗方案药物疗效心理因素生理因素检测结果疾病患者准确性协调性呼吸道特点临床

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Combined application of three evoked potentials to improve the diagnosis of multiple sclerosis

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Neural Regeneration Research 2006年第6期1卷 569-572页

作者： Xiaoyi Li Neuroelect rophysiological Center Guizhou Provincial People＇s Hospital Guiyang 520002 Guizhou Province China

BACKGROUND ： It is very important to find out the focal sites for the early diagnosis of multiple sclerosis, especially the discovery of tiny or potential focal site, so that multiple sclerosis can be diagnosed at the early period （the first attack） or when the focus has not displayed completely, and the evoked potential can discover the abnormality of the pathway between spinal cord to cerebral cortex. OBJECTIVE： To observe the values of motor evoked potential （MEP）, somatosensory evoked potential （SEP） and evoked-related potential （P300） in the diagnosis of multiple sclerosis. DESIGN： A case-controlledstudy SETTING： Neuroelectrophysiological Center of Guizhou Provincial People＇s Hospita PARTICIPANTS ： Twenty-five outpatients or inpatients with multiple sclerosis were selected from the Department of Neurology, Guizhou Provincial People＇s Hospital from October 2001 to March 2005. The patients were diagnosed according to the diagnostic standards of multiple sclerosis suggested by Poser et al in 1983 and MRI examination. There were 17 males and 8 females, aged 18-65 years old with an average of 39 years, and their disease courses ranged from 6 months to 5 years. Meanwhile, 30 healthy physical examinees were selected in our hospital as the control group, and they all had no abnormality by detailed inquisition, physical examination and examination of nervous system, including 15 males and 5 females, aged 20-66 years old. All the enrolled subjects were informed and agreed with the detections. METHODS ：（1） The MEP, SEP and P300 were detected with synergy evoked potential equipment （Oxford Instruments, UK） in all the 25 patients with multiple sclerosis and 20 healthy subjects. （2） Standards for judging the abnormalities of evoked potentials： The abnormalities referred to deletion of wave form or the latency was prolonged by more than the reference value of normal subject±3SD. （3） The differences of measurement data were compared with the ttest.MAIN OUTCOME MEA

关键词： multiple sclerosis diagnosis of motor evoked potential cognitive function evoked potentials measurement data reference value cerebral cortex nervous system examination of spinal cord

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堤防加固设计中的若干技术问题

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人民长江 2001年第S1期32卷 41-44页

作者： ZHANG Jia-fa Professor Yangtze River Scientific Research Institute Senior Engineer Yangtze River Scientific Research Institute

The dyke experiences very high flood level more and more frequently. The timely issued ' The Standard of Dyke Design' has played an important role in the design, measure fea sibility study and examination of dyke reinforcement. Safety appraisal is required before dyke rein forcement design. But, the conducted item is safety demonstration in the process of dyke reinforcement design at present. This paper suggests that at least 8 aspects should be considered in safety demo nstration. The effective water head is considered as the most important factor for dyke safety and reinfo rcement design. Seepage control measure design is an important part of dyke reinforcement design . Its correct train of thought is discussed in this paper. Some other factors for dyke reinforcement d esign are also pointed out.

关键词：堤防加固设计 control measure examination of flood level

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Unique Cyclin-Dependent Kinase (CDK) Inhibitors at the ATP-site

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Chemical Research in Chinese Universities 2001年第Z1期17卷 111-页

作者： LI Lin

Control of the cell cycle could be applicable in new approaches for cancer chemotherapy. The cyclin-dependent kinases (CDK's) and their corresponding complexes with cyclins are regulatory enzymes for which we have discovered a novel small molecule series of inhibitors, with potencies in the nanomolar range and good selectivity for the CDK's versus other kinases. We will discuss structure-based drug design efforts with crystal structures of complexes with certain CDK's. Cellular effects and some preliminary examination of in vivo cancer efficacy by these inhibitors will also be discussed.

关键词： cancer chemotherapy small molecule examination of drug design cell cycle

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Progressive Neuronal Degeneration of Childhood with Liver's Disease (Alpers' Disease) Clinical Features and Neuropathological Studies of 4 Sibling

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中国临床神经科学 2000年第Z1期8卷 95-95页

作者： Yupu Guo Zhong Guo Haowen Liu Mingwe Wang Hongwei Duan Shufang Gao Haitao Ren Department of Neurology Peking Union Medical College HospitalBeijing100730

We report four siblings of a family with Alpers'*** of four siblings occurred diarrhea and myoclonus at the ages of 7 to 8 years *** the disease evolution,symptoms of subacute encephalopathy such as headache,visual disturbance,cortical blindness,progressive seizures and mental retardation were presented at the ages of 15 to 20 years *** progression led them to death in multiple organ failure within six to eight months of *** showed hypodensity lesions in the bilateral oc cipital and temporal *** changes,which characterized by diffuse neuronal degeneration or loss and astrocytosis,were most severe in the gray *** matter was slightly involved,while basal ganglia,pons,brain stem and cerebellum were not *** examination of the only live brother of the four siblings showed short status(165 cm),arched feet and improper nose-pointed test of the left *** biopsy of him showed a large amount of Red-Ragged(RR)fibers and abnormal *** features and pathological findings of autopsy in all the four siblings were consistent with progressive neuronal degeneration of childhood with liver disease(PNDC)-Alpers'*** muscle biopsy showed the characteristic findings of mitochondrial *** report confirmed the classification of late onset Alpers'disease as a mitochondrial disorders.

关键词： neuronal degeneration multiple organ failure mental retardation examination of liver disease basal ganglia

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