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Establishing a cat model of acute optic nerve injury

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Neural Regeneration Research 2007年第9期2卷 552-556页

作者： Feng Yu Gang Sui Shaoji Yuan Rongwei Zhang Zisheng Liu Peigang Lu Department of Neurosurgery General Hospital of Ji＇nan Mifitary Area Command of Chinese PLA Ji＇nan 250031 Shandong ProvinceChina

BACKGROUND： In order to investigate the progress in optic nerve injury and the following regeneration and repair, many kinds of animal models of optic nerve injury have been established, such as models of acute and chronic ocular hypertension, compression, amputating wound, ischemia reperfusion or hypoxia, intravitreal injection of excitatory amino acids, etc. However, most of these models are established by squeezing intraorbital optic nerve, and suitable for ophthalmology, and there are fewer models suitable for the acute cranial contusion in neurosurgery. OBJECTIVE： To observe the changes of optic nerve after acute injury, and the characteristics of methods for establishing model of acute optic nerve injury in cats. DESIGN： A complete randomized grouping and controlled animal trial. SETTING： Department of Neurosurgery, General Hospital of Ji＇nan Military Area Command of Chinese PLA. MATERIALS： Twenty-eight healthy adult cats, common degree, either sex, weighing 2.0-3.5 kg, were provided by the animal experimental center of Fudan University. The cats were randomly divided into control group （n =3） and model group （n =25）, and 5 cats in the model group were observed at 6 hours and 1, 3, 7 and 14 days after injury respectively. JX-2000 biological signal processing system （Department of Physiology, Second Military Medical University of Chinese PLA, Shanghai）; Inverted phase contrast microscope （Olympus）; Axioplan 2 imaging microgram analytical system （Labsystems）. METHODS： The experiments were carried out in the Department of Neurosurgery, General Hospital of Jinan Military Area Command of Chinese PLA from June 2004 to June 2005. The cats in the model groups were made into models of acute optic nerve injury： The cats were anesthetized, then the limbs were fixed in a lateral recumbent position. Pterion approach in human was imitated, the operative incision was made along the line between lateral canthus and tragus, and it could be seen deep along the skull bas

关键词： optic nerve injuries models, animal evoked potentials, visual

Efficacy of nerve growth factor on the treatment of optic nerve contusion Evaluation with visual evoked potential

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Neural Regeneration Research 2007年第9期2卷 565-568页

作者： Aihong Miao Xiaoling Liu Shujuan Lue Department of Ophthalmology Tangshan Worker Hospital Affiliated to Hebei Medical University Tangshan 063000 Hebei ProvinceChina Electromyogram Room Kailuan Hospital for Bureau of Mines Tangshan 063000 Hebei Province China

BACKGROUND： Pattern- visual evoked potential （PVEP） can reflect the functional status of retinal ganglial cells （RGC） and visual cortex, and is an objective examination for visual pathway function. It is a unique method for objectively examining the optic nerve function of optic ganglion cells. OBJECTIVE： To observe the effects of nerve growth factor （NGF） on PVEF in the treatment of optic nerve contusion, evaluate the clinical efficacy of NGF, and make an efficacy comparison with vitamin B12. DESIGN： A randomly grouping, controlled observation. SETTING： Department of Ophthalmology, Tangshan Gongren Hospital Affiliated to Hebei Medical University. PARTICIPANTS： Forty patients with optic nerve contusion caused by eye trauma, who received the treatment in the Tangshan Worker Hospital Affiliated to Hebei Medical University between January 2006 and June 2007, were recruited in this study. The involved 40 patients, including 34 males and 6 females, were aged 14-59 years. They were confirmed to have optic nerve contusion by ophthalmologic consultation combined with history of disease and orbital CT examination. Informed consents of treatments and detected items were obtained from all the patients. The patients were randomly divided into 2 groups with 20 in each： NGF group and vitamin B12 group. METHODS： Conservative treatment was used in the two groups. In addition, patients in the NGF group were intramuscularly injected with NGF solution 18 μg /time, once a day. Those in the vitamin B12 group were injected by the same method with common vitamin B12 of 500 μg combined with vitamin B1 of 100 mg, once a day. MAIN OUTCOME MEASURES： PVEP examination was conducted in all the patients before, one and two weeks after treatment, and latency and amplitude at P100 were detected. RESULTS： Forty patients with optic nerve contusion participated in the final analysis. Before treatment, significant differences in the latency and amplitude at P100 were not found in patients b

关键词： nerve growth factors optic nerve/injuries contusions evoked potentials, visual

A STUDY ON visual evoked POTENTIAL TO SHOW THE RELATIONSHIP BETWEEN THE EYES AND THE TWELVE REGULAR CHANNELS

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Journal of Traditional Chinese Medicine 1998年第2期18卷 140-145页

作者：段俊国周华详陈晓莉潘学会袁晓辉李翔肖挹胡雪云 Chengdu University of Traditional Chinese Medicine and Pharmacy.

The visual electrophysiologic method was used to investigate the relationship between the eyes and the 12 regular channels. The values of the latent period and the amplitude of P100 wave were calculated and compared statistically. The results show that: 1) The eyes and the 12 regular channels are closely related, no matter whether the channels are classically associated with the eyes or not, while the control (non-channel)/ point has no such relationship; 2) the degrees of relationship between the eyes and the 12 regular channels vary significantly; and 3) acupuncture at the 12 regular channels induces different effects on the visual evoked potential that the Urinary Bladder Channel presents a facilitation effect whereas all the other channels chiefly show an inhibitory effect.

关键词： Electroacupuncture evoked potentials, visual Eye Meridians Adolescent Adult Female Humans Male

Regulation of acupuncture on NMDAR1 mRNA expression in visual cortex of monocularly-deprived rats

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Journal of Acupuncture and Tuina Science 2017年第1期15卷 1-7页

作者： Zhu Tian-tian Chen Cheng Yan Xing-ke School of Acupuncture and Tuina Gansu University of Chinese Medicine Lanzhou 730000 China Health Management Center Daqing Hospital of Traditional Chinese Medicine Daqing 163311 China

Objective： To explore the molecular biological mechanism of acupuncture in intervening visual deprivation. Methods： Forty-eight 2-week old Wistar rats were randomly divided into a normal group, a model group, and 6 acupuncture groups （group C1： acupuncture at the unaffected side in early stage; group C2： acupuncture at the affected side in early stage; group DI： acupuncture at the unaffected side in mid-stage; group D2： acupuncture at the affected side in mid-stage; group El： acupuncture at the unaffected side in late stage; group E2： acupuncture at the affected side in late stage） by the random number table, 6 rats in each group. Rats in the normal group didn＇t receive any interventions. The rat model of deprivation amblyopia was established by unilateral eyelid suture in the model group and each acupuncture group After successful modeling, rats in model group didn＇t receive any treatments; rats in the acupuncture groups received acupuncture intervention which began respectively on the 3rd, 12th and 21st day after modeling. Pattern visual evoked potential （P-VEP） and N-methy D-aspartatreceptor-1 （NMDAR1） mRNA expression in visual cortex area 17 were detected at the end of acupuncture intervention in each group. Results： After the intervention, the P-VEP waveform was significantly changed, with a significantly delayed Pzoo value （P〈0.01） and significantly decreased amplitude of N45-Ploo in the model group versus the normal group （P〈O.01）; the P-VEP waveform was significantly improved, with obviously earlier P10o （P〈0.01） and increased amplitude of N4s-Ploo （P〈O.05） in each acupuncture group versus the model group. The improvement effect of acupuncture on the P-VEP waveform in group C1 and C2 was more significant than that in group D1, D2, E1 and E2. The expression of NMDAR1 mRNA of the rat visual cortex area 17 in the model group was significantly lower than that in the normal group （P〈0.01）; and the expression of NMDAR1 mRNA in the visual cortex area 17 of each acu

关键词： Acupuncture Therapy Amblyopia Receptors, N-MethyI-D-Aspartate NMDA receptor A1 evoked potentials, visual Rats