检索结果-南通市图书馆

Frontiers of Architectural Research 2022年第5期11卷 815-829页

作者： Xin Yi Fei Zhai School of Architecture Southeast UniversityNanjing 210096China Key Laboratory of Urban and Architectural Heritage Conservation(Southeast University) Ministry of EducationNanjing 210096China

events can bring important impetus to urban development.In addition to hardware investments,such as infrastructure,events also have important potential in the development of knowledge cities.Nanjing is a typical city where China’s knowledge industry is rapidly growing.Since the end of the last century,Nanjing has been promoting new district development on the city’s periphery and has hosted a series of events,including the 10th National Games in 2005 and the 2nd Youth Olympic Games in 2014.In this process,the city government also hopes to explore the potential of the knowledge economy and is committed to providing a new direction for urban development.This work reviews the history of Nanjing’s knowledge city development from two different dimensions(land development and knowledge development)and summarises the related achievements and lessons in different periods.The authors aim to identify the diverse effects of events in urban social and economic development based on the analysis of the differences in governance structure between land development and knowledge development.This work contributes to the literature on events and provides insights into the potential uses of events as a mechanism for knowledge-driven urban development.

关键词： New district development Knowledge city events Urban transformation

Plasma biomarkers and plaque strain predict long-term cardiovascular events in patients with acute coronary syndrome

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Science China(Life Sciences) 2020年第2期63卷 269-278页

作者： Mingjun Xu Xiaobo Hu Lin Wang Wei Zhang Lindi Wu Jifu Li Yuguo Chen Pengfei Zhang Haijun Su Yaling Han Cheng Zhang Mei Zhang Yun Zhang The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineDepartment of CardiologyQilu Hospital of Shandong UniversityJinan 250012China Department of Intensive Care Unit Shandong Provincial Hospital affiliated to Shandong UniversityJinan 250012China School of Mathematics Shandong UniversityJinan 250012China Department of Cardiology Shenyang Military Region General HospitalShenyang 110016China

To test whether circulating and intracoronary biomarkers and coronary plaque strain have additive values to Global Registry of Acute Coronary events(GRACE) score for predicting long-term cardiovascular events in ACS patients. One hundred ACS patients were enrolled and the GRACE score and plasma levels and intracoronary gradients of a number of biomarkers were measured. Coronary plaque burden and morphology in non-critical stenotic plaques were determined by intravascular ultrasound(IVUS) technique, and the maximal shear strain(SSmax) and maximal area strain(ASmax) were determined by intravascular ultrasound elastography(IVUSE) technique. Patients were followed for cardiovascular events and the predictive values of clinical characteristics, plasma biomarkers and plaque parameters were compared with GRACE score, and the incremental values of these measurements to the GRACE score were assessed. GRACE score, plasma biomarkers and plaque strain were independent predictors of cardiovascular events. Combination of GRACE score, plasma biomarkers and plaque strains significantly improved the predictive value of the GRACE score alone with the receiver-operating characteristic area increased from0.457 to 0.667(P=0.014). The combination of circulating and intracoronary biomarkers, plaque strain and GRACE score provides a better predictive tool than GRACE score alone in patients with ACS.

关键词： plasma biomarker plaque strain GRACE score cardiovascular events acute coronary syndrome

Clinical outcomes and predictive model of platelet reactivity to clopidogrel after acute ischemic vascular events

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Chinese Medical Journal 2019年第9期132卷 1053-1062页

作者： Qi Ma Guang-Zhong Chen Yu-Hu Zhang Li Zhang Li-An Huang Department of Neurology The First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510632China Guangdong Geriatrics Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Neurosurgery Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Neurology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China

Background:High on-treatment platelet reactivity (HTPR) has been suggested as a risk factor for patients with ischemic vascular disease.We explored a predictive model of platelet reactivity to clopidogrel and the relationship with clinical outcomes.Methods:A total of 441 patients were included.Platelet reactivity was measured by light transmittance aggregometry after receiving dual antiplatelet therapy.HTPR was defined by the consensus cutoff of maximal platelet aggregation >46% by light transmittance aggregometry.CYP2C19 loss-of-function polymorphisms were identified by DNA microarray analysis.The data were compared by binary logistic regression to find the risk factors.The primary endpoint was major adverse clinical events (MACEs),and patients were followed for a median time of 29 months.Survival curves were constructed with Kaplan-Meier estimates and compared by logrank tests between the patients with HTPR and non-HTPR.Results:The rate of HTPR was 17.2%.Logistic regression identified the following predictors of HTPR:age,therapy regimen,body mass index,diabetes history,CYP2C19^*2,or CYP2C19^*3 variant.The area under the curve of receiver operating characteristic for the HTPR predictive model was 0.793 (95% confidence interval:0.738–0.848).Kaplan-Meier analysis showed that patients with HTPR had a higher incidence of MACE than those with non-HTPR (21.1% vs.9.9%;χ^2 = 7.572,P = 0.010).Conclusions:Our results suggest that advanced age,higher body mass index,treatment with regular dual antiplatelet therapy,diabetes,and CYP2C19^*2 or CYP2C19^*3 carriers are significantly associated with HTPR to clopidogrel.The predictive model of HTPR has useful discrimination and good calibration and may predict long-term MACE.

关键词： High on-treatment platelet reactivity Clopidogrel CYP2C19 Light transmittance aggregometry Ischemic vascular events

Electrocardiographic predictors of cardiovascular events in patients at high cardiovascular risk: a multicenter study

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Journal of Geriatric Cardiology 2019年第8期16卷 630-638页

作者： Rungroj Krittayaphong Muenpetch Muenkaew Polakit Chiewvit Nithima Ratanasit Yodying Kaolawanich Arintaya Phrommintikul Division of Cardiology Department of MedicineFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Division of Cardiology Department of MedicineFaculty of MedicineThammasat UniversityPathum ThaniThailand Department of Internal Medicine Faculty of MedicineChiang Mai UniversityChiang MaiThailand

Background There are limited data on the prevalence of electrocardiographic (ECG) abnormalities, and their value for predicting a major adverse cardiovascular event (MACE) in patients at high cardiovascular risk. This study aimed to determine the prevalence of ECG abnormalities in patients at high risk for cardiovascular events, and to identify ECG abnormalities that significantly predict MACE. Methods Patients aged ≥ 45 years with established atherosclerotic disease (EAD) were consecutively enrolled from the outpatient clinics of the six participating hospitals during April 2011 to March 2014. The following data were collected: demographic data, cardiovascular risk factors, history of cardiovascular event, physical examination, ECG and medications. ECG was analyzed using Minnesota Code criteria. MACE included cardiovascular death, non-fatal myocardial infarction, and hospitalization due to unstable angina or heart failure. Results A total of 2009 patients were included, 1048 patients (52.2%) had established EAD, and 961 patients (47.8%) had multiple risk factors (MRF). ECG abnormalities included atrial fibrillation (6.7%), premature ventricular contraction (5.4%), pathological Q-wave (Q/QS)(21.3%), T-wave inversion (20.0%), intraventricular ventricular conduction delay (IVCD)(7.3%), left ventricular hypertrophy (LVH)(12.2%), and AV block (12.5%). MACE occurred in 88 patients (4.4%). Independent predictors of MACE were chronic kidney disease, EAD, and the presence of atrial fibrillation, Q/QS, IVCD or LVH by ECG. Conclusions A high prevalence of ECG abnormalities was found. The prevalence of ECG abnormalities was high even among those with risk factors without documented cardiovascular disease.

关键词： Cardiovascular events Electrocardiographic High cardiovascular risk Predictors

Adverse events related to colonoscopy: Global trends and future challenges

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World Journal of Gastroenterology 2019年第2期25卷 190-204页

作者： Su Young Kim Hyun-Soo Kim Hong Jun Park Department of Internal Medicine Yonsei University Wonju College of Medicine

Colonoscopy is a widely used method for diagnosing and treating colonic disease. The number of colonoscopies is increasing worldwide, and concerns about associated adverse events are growing. Large-scale studies using big data for post-colonoscopy complications have been reported. A colon perforation is a severe complication with a relatively high mortality rate. The perforation rate, as reported in large studies(≥ 50,000 colonoscopies) published since 2000, ranges from 0.005-0.085%. The trend in the overall perforation rate in the past 15 years has not changed significantly. Bleeding is a more common adverse event than perforation. Recent large studies(≥ 50,000 colonoscopies) have reported postcolonoscopy bleeding occurring in 0.001-0.687% of cases. Most studies about adverse events related to colonoscopy were performed in the West, and relatively few studies have been conducted in the East. The incidence of post-colonoscopy complications increases in elderly patients or patients with inflammatory bowel diseases. It is important to use a unified definition and refined data to overcome the limitations of previous studies. In addition, a structured training program for endoscopists and a systematic national management program are needed to reduce post-colonoscopy complications. In this review, we discuss the current trends in colonoscopy related to adverse events, as well as the challenges to be addressed through future research.

关键词： Colonoscopy Adverse events Perforation Bleeding Post-colonoscopy

A research progress review on regional extreme events

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Advances in Climate Change Research 2018年第3期9卷 161-169页

作者： REN Fu-Min Blair TREWIN Manola BRUNET Pattanaik DUSHMANTA Andreas WALTER Omar BADDOUR Maya KORBER State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Beijing 100081 China Bureau of Meteorology Melbourne VIC 3001 Australia Centre for Climate Change Department of Geography University Rovira i Virgili Tarragona 43007 Spain Climatic Research Unit School of Environmental Sciences University of East Anglia Norwich NR4 7TJ UK India Meteorological Department New Delhi 110003 India German Meteorological Service (DWD) Offenbach 63067 Germany World Meteorological Organization Geneva 1211 Switzerland

An extreme （weather and climate） event does not only mean that an extreme occurs at a location, but more generally it can impact a certainarea and last a certain period of time, which is defined as a regional extreme event （REE） with a certain impacted area and duration. The conceptof REE has been defined to allow mainly objective assessment of the events without a pre-determined boundary and duration. This paper reviewsthe studies on REEs published during the past 20 years, especially recent years. Mainly in view of methodology, these studies can be divided intothree types studies focusing on spatial simultaneity, studies focusing on temporal persistence, and studies identifying REEs. The methodsidentifying REEs include two kinds, e.g., type-I methods stressing REE＇s temporal persistence within a relatively certain area and type-IImethods focusing on catching a complete REE. Identification methods proposed in this paper could provide valuable information for variouspurposes, such as real-time monitoring, estimating long-term changes, mechanism diagnosis, forecasting study and even attribution analysis.Research on REEs is important for objectively defining extreme weather and climate events, which depends on the spatial and temporal scales ofinterest. Such an objective definition will support ongoing climate monitoring and improve the assessment of how regional extreme events havechanged over time.

关键词： Extreme (weather and climate) events Regional extreme events Research progress Review

Influence of the Arctic on the Predictability of Eurasian Winter Extreme Weather events

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Advances in Atmospheric Sciences 2020年第4期37卷 307-317页

作者： Guokun DAI Mu MU Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China

The linkage between the Arctic and midlatitudes has received much attention recently due to the rapidly changing climate.Many investigations have been conducted to reveal the relationship between the Arctic and Eurasian extreme events from the perspective of climatological statistics.As a prediction source for extreme events in Eurasia,Arctic conditions are crucial for extreme event predictions.Therefore,it is urgent to explore the Arctic influence on the predictability of Eurasian extreme events due to the large uncertainties in Arctic conditions.Considering the sensitivity and nonlinearity of the atmospheric circulations in midlatitude to Arctic conditions,it is necessary to investigate the Arctic influences on Eurasian extreme weather events in case studies at weather time scales.Previous studies indicate that only perturbations in specific patterns have fast growth.Thus,the conditional nonlinear optimal perturbation approach is recommended for exploring the uncertainties in Arctic initial and boundary conditions and their synergistic effect on Eurasian extreme events.Moreover,the mechanism for extreme event formation may differ in different cases.Therefore,more extreme cases should be investigated to reach robust conclusions.

关键词： Arctic uncertainties Eurasian extreme weather events synergistic effect optimization algorithms

Reply to Zwaenepoel et al.: Meeting the Challenges of Detecting Polyploidy events from Transcriptomic Data

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Molecular Plant 2019年第2期12卷 137-140页

作者： Haifeng Wang Chunce Guo Hong Ma Ji Qi State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi Key Lab of Sugarcane Biology College of Agriculture Guangxi University Nanning Guangxi China Jiangxi Provincial Key Laboratory for Bamboo Germplasm Resources and Utilization Forestry College Jiangxi Agricultural University Nanchang China Department of Biology and the Huck Institutes of the Life Sciences The Pennsylvania State University University Park PA USA State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China

Dear Editor,Transcriptomic data have been widely employed to infer whole genome duplications (WGDs, or paleopolyploidy)(Jiao et al., 2011;Barker et al., 2016;Huang et al., 2016), through the use of large numbers of re... 详细信息

关键词： Challenges Detecting Polyploidy events Transcriptomic Data

Environmental and Dynamic Conditions for the Occurrence ofPersistent Haze events in North China

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Engineering 2017年第2期3卷 266-271页

作者： Yihui Ding Ping Wu Yanju Liu Yafang Song National Climate Center Beijing 100081 China Chinese Academy of Meteorological Sdences Beijing 100081 China College of Atmospheric Science Nanjing University o.f lnforrnation Sdence and Technology Nanjing 210044 China

This paper presents a concise summary of recent studies on the long-term variations of haze in NorthChina and on the environmental and dynamic conditions for severe persistent haze events. Resultsindicate that haze days have an obviously rising trend over the past 50 years in North China. Theoccurrence frequency of persistent haze events has a similar rising trend due to the continuous riseof winter temperatures, decrease of surface wind speeds, and aggravation of atmospheric stability. InNorth China, when severe persistent haze events occur, anomalous southwesterly winds prevail in thelower troposphere, providing sufficient moisture for the formation of haze. Moreover, North China ismainly controlled by a deep downdraft in the mid-lower troposphere, which contributes to reducing thethickness of the planetary boundary layer, obviously reducing the atmospheric capacity for pollutants.This atmospheric circulation and sinking motion provide favorable conditions for the formation andmaintenance of haze in North China.

关键词： North China Persistent haze events Environmental conditions Dynamic conditions

Changes in extreme precipitation events over the Hindu Kush Himalayan region during 1961e2012

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Advances in Climate Change Research 2017年第3期8卷 166-175页

作者： ZHAN Yun-Jian REN Guo-Yu Arun Bhaka SHRESTHA Rupak RAJBHANDARI REN Yu-Yu Jayanarayanan SANJAY XU Yan SUN Xiu-Bao YOU Qing-Long WANG Shu National Meteorological Information Center China Meteorological Administration Beijing 100081 China Department of Atmospheric Science School of Environmental Studies China University of Geosciences Wuhan 430074 China Chinese Academy of Meteorological Sciences China Meteorological Administration Beijing 100081 China University of Chinese Academy of Sciences Beijing 100049 China Laboratory for Climate Studies National Climate Center China Meteorological Administration Beijing 100081 China International Centre for Integrated Mountain Development Kathmandu 3226 Nepal Department of Meteorology Tri-Chandra Campus Tribhuvan University Kathmandu 3226 Nepal Indian Institute of Tropical Meteorology Pune 411008 India College of Atmospheric Science Nanjing University of Information Science & Technology Nanjing 210044 China

Based on a new multi-source dataset (GLDP-V1.0) recently developed in China Meteorological Administration, we employed precipitation indices including percentile-based indices of light (below the 50th percentile), moderate (between the 50th and 90th percentile), and intense (above the 90th percentile) precipitation, maximum 1-day, 3-day, and 5-day precipitation amounts (RX1DAY, RX3DAY, and RX5DAY, respectively), and consecutive wet and dry days (CWDs and CDDs) to analyze variations in extreme precipitation events in the Hindu Kush Himalayan (HKH) during 1961e2012. The main results are presented as follows. Firstly, there was a significant increase in the amount of light and moderate precipitation and number of associated days over various parts of India and northern Tibetan Plateau during 1961e2012; but the intensity of light precipitation decreased significantly in the Hindu Kush and central India, and the regional average intensity also decreased. Secondly, the amount and frequency of intense precipitation mostly increased significantly on the Tibetan Plateau, but there was a heterogeneous change over the remainder of the HKH, and regional average annual intense precipitation amount and frequency significantly increased over the HKH during 1961e2012. Thirdly, regional average RX1DAY, RX3DAY, and RX5DAYall showed significant upward trends during 1961e2012, and there was a significant increased tendency of consecutive wet-days in most parts of the study region; however, trends of consecutive dry-days were mostly opposite to those of consecutive wet-days, with regional averaged consecutive dry-days showing no noticeable trend.

关键词： Climate change Trend Extreme precipitation events HKH region Tibetan Plateau