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Characterization of event-related potentials in obsessive compulsive disorder patients: Comparison with depression and generalized anxiety disorder patients

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Neural Regeneration Research 2010年第12期5卷 938-941页

作者： Yingzhi Lu Wenbin Zong Hanzhen Dong Faxin Wang Jinyu pU Xingshi Chen Yunxiang Tang Department of psychiatry Fifth People's Hospital ofZibo Zibo 255120 Shandong Province China Department of Neurophysiology Shanghai Mental Health Center Shanghai Jiao Tong University Shanghai 200030 China

BACKGROUND： Study results of event-refated potential in obsessive compulsive disorder （OCD） remain controversial, potentially as a result of different instruments utilized and their differing technical characteristics. OBJECTIVE： To investigate the differences in several common event-related potentials, Le. contingent negative variations, p300, and mismatch negativity （MMN）, in OCD patients, depression patients, generalized anxiety disorder （GAD） patients, and healthy controls. DESIGN, TIME AND SETTING： A case-control study was performed in the Department of Electrophysiology, Shanghai Mental Health Center from May 2002 to December 2005. pARTICIpANTS： A total of 38 OCD patients, 20 depression patients, and 18 GAD patients, who were diagnosed according to the criteria of Chinese Classification of Mental Disorders （Version 3）, formulated by the Chinese psychiatry Association, were selected from the Outpatient Department of Shanghai Mental Health Center. patients with two or more the above diseases were excluded. In addition, 28 healthy people, gender and age matched, were selected as controls. METHODS： Contingent negative variations, p300, and MMN were recorded by a Nicolet Spirit Instrument. All electrodes were attached at Cz according to the Intemationa11020 system, with the mastoid leads as reference and Fpz as ground. MAIN OUTCOME MEASURES： Amplitude and latency of contingent negative variations, p300, and MMN. RESULTS： The contingent negative variations, p300, and MMN were different （p 〈 0.01）. OCD patients showed an increased MI amplitude compared with controls, depression, and GAD patients （p 〈 0.01）. Target p300 amplitudes were significantly lower in OCD, depression, and GAD patients compared with controls （p 〈 0.01）. Moreover, N2 latency and latency of MMN were prolonged in OCD and depression groups compared with controls （p 〈 0.05）. CONCLUSION： event-related potentials were different in depression, GAD, and OCD patients and healthy controls. In particular, O

关键词： obsessive compulsive disorder depression generalized anxiety disorder contingent negative variation event-related potential-p300 mismatch negativity

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