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Optimizing the Dosage Regimen of Micafungin against <i>Candida spp</i>in HIV Positive Patients with EC Based on Mote Carlo Simulation

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Open Journal of Preventive Medicine 2020年第6期10卷 120-125页

作者： Ying Wang Jingyi Zhao Song Jiang Yinhui Yao Hainan Wen Department of Pharmacy The Affiliated Hospital of Chengde Medical College Chengde China Department of Functional Center Chengde Medical College Chengde China Department of Clinical Laboratory The Affiliated Hospital of Chengde Medical College Chengde China

The objective of our study was to explore the possibility of the antifungal efficacy of various micafungin dosage regimens against Candida spp in HIV positive patients with EC. According to pharmacokinetic/pharmacodynamics parameters of micafungin in HIV positive patients and MICs distribution of micafungin against Candida spp. in published studies, the dosage regimens of micafungin were 50, 100 and 150 mg QD iv. Monte Carlo Simulation analysed the probability of target attainment and cumulative fraction of response. The results showed that micafungin has good antifungal effect in treating HIV positive patients with EC when pathomycetes are Candida albicans, Candida glabrata or Candida tropicalis, in dosage at 100 mg QD and 150 mg QD.

关键词： Monte Carlo Simulation Micafungin HIV Positive Patients esophageal candidiasis

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candidiasis Treatment Should Pay Attention to the Immune Changing Patients

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Open Journal of Internal Medicine 2016年第2期6卷 31-36页

作者： Xiaoyang Yang Mengjie Wan Fangping Chen Department of Hematology Affiliated Haikou Hospital Central South University Haikou Municipal Hospital Haikou China Department of Hematology Xiangya Hospital Central South University Changsha China

The guideline of the Infectious Diseases Society of America (IDSA) about candidiasis is a key standard for clinical doctors to treat patients, and textbook to teach medical students. However, in the progress of clinical treatment and documents checking, the immune changing patients, who suffered candidiasis, may be mismatched to the clinical treatment guidelines. The opinion could be shown by the literature of gastrointestinal system, and respiratory system, which suffered severely fungal infection mostly, mainly connected with the outside world and inside organ systems of the human body. They could show some patients have been excess treatment, and we should pay attention to the immune changing patients.

关键词： candidiasis Infectious Diseases Society of America esophageal candidiasis

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esophageal intramural pseudodiverticulosis,a rare cause of food impaction:case report and review of the literature

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Gastroenterology Report 2015年第2期3卷 175-178页

作者： Yahuza Siba Saritha Gorantla Anand Gupta Edward Lung Joan Culpepper-Morgan Department of Medicine Columbia University Medical CenterHarlem Hospital CenterNew YorkNYUSA Division of Gastroenterology Department of MedicineColumbia University Medical CenterHarlem Hospital CenterNew YorkNYUSA

esophageal intramural pseudodiverticulosis(EIPD)is a rare,benign condition of uncertain etiology and pathogenesis,which usually presents with either progressive or intermittent *** presentation with food impaction,requiring emergency esophago-gastroduodenoscopy(EGD),is *** report a case of EIPD presenting as food bolus impaction in an elderly black *** patient had no previous history of dysphagia or *** accepted risk factors,such as diabetes mellitus,chronic alcoholism,and reflux esophagitis,were not present in our *** EGD established the diagnosis and also dislodged the food *** evaluation of the mucosa diagnosed co-existent acute candidal *** treatment with proton pump inhibitor and azole antifungal led to resolution of her *** of the literature revealed that stenosis,strictures,perforation,gastro-intestinal bleed,and fistula formation are potential complications of *** motility abnormalities have been described but are not *** of the underlying inflammatory and or infectious condition is the mainstay of management of this unusual condition.

关键词： esophageal intramural pseudodiverticulosis food impaction dysphagia esophageal candidiasis

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