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Chinese Journal of Cancer 2017年第9期36卷 438-443页

作者： Renbo Guo Yiran Liang Lei Yan Zhonghua Xu Juchao Ren Department of Urology Shandong Cancer Hospital Affiliated to Shandong UniversityJinan 250117ShandongP.R.China Department of Breast Surgery QiLu Hospital Shandong UniversityJinan 250012ShandongP.R.China Department of Urology QiLu HospitalShandong UniversityJinan 250012ShandongP.R.China

Background:erythrocytosis,a rare paraneoplastic syndrome,generally occurs in patients with clear cell renal cell carcinoma and has never been reported in patients with chromophobe renal cell *** presentation:We report a case of a young man suffering from a giant(22-cm) mass on his left *** of a history of polycythemia vera,the patient had been treated for the condition for 9 *** nephrectomy was successfully performed,and the postoperative pathologic examination confirmed a diagnosis of chromophobe renal cell ***,the symptom of erythrocytosis disappeared after the *** examination and analysis were performed,and we finally attributed his erythrocytosis to chromophobe renal cell ***:Chromophobe renal cell carcinoma could cause erythrocytosis,but the clear-cut mechanism needs further *** erythrocytosis such as those related with renal tumors should be taken into consideration during the diagnosis of polycythemia vera.

关键词： Chromophobe renal cell carcinoma Polycythemia vera erythrocytosis Misdiagnosis

Pheochromocytoma as a cause of repeated acute myocardial infarctions,heart failure,and transient erythrocytosis:A case report and review of the literature

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World Journal of Clinical Cases 2021年第4期9卷 951-959页

作者： Fei Shi Li-Xian Sun Sen Long Ying Zhang Department of Cardiology Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina Department of Traditional Chinese Medicine Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina

BACKGROUND Pheochromocytoma is a rare catecholamines-secreting tumor arising from chromaffin cells in the adrenal *** classically presents with paroxysmal hypertension,headaches,palpitations,sweating,and metabolic *** presentations such as acute myocardial infarction,heart failure,cardiomyopathy,stroke,and transient erythrocytosis have been infrequently *** SUMMARY We describe the case of a 72-year-old man diagnosed with pheochromocytoma presenting with non-ST segment elevation myocardial infarction,heart failure,and transient erythrocytosis with nonobstructed coronary *** was his second heart *** patient was previously diagnosed with myocardial infarction,and an immense mass was found on the left adrenal gland 3 years *** on clinical and laboratory findings,a diagnosis of pheochromocytoma was *** coronary angiogram showed nonobstructed coronary arteries except for a myocardial bridge in the left anterior descending *** was a form of type-2 myocardial *** myocardial cell lesions were caused by sudden secretion of catecholamines by the *** more atypically,his hemoglobin level was obviously elevated at admission,but after a few days of treatment with an alpha-adrenergic receptor blocker,it dropped to normal levels without additional *** Pheochromocytoma may be a cause of acute myocardial infarction,heart failure,and transient erythrocytosis.

关键词： Pheochromocytoma Myocardial infarction Heart failure Cardiomyopathy erythrocytosis Case report

Myomatous erythrocytosis syndrome:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3206-3212页

作者： Xin-Yu Shu Na Chen Bi-Yun Chen Hui-Xia Yang Hui Bi Department of Obstetrics and Gynaecology Peking University First HospitalBeijing 100034China Department of Obstetrics and Gynaecology The Hospital of Cang TownCangzhou 223900Hebei ProvinceChina

BACKGROUND Uterine myoma is the most common benign tumor among women and is often accompanied by ***,we report the case of a patient with a very large leiomyoma but with a hemoglobin level as high as 197 g/*** undergoing hysterectomy,all her hematological parameters returned to *** staining of her myoma for erythropoietin showed strong positivity,which suggested that erythropoietin may be the cause of her erythrocytosis.A multidisciplinary team played a significant role in treating the *** SUMMARY A 47-year-old woman visited our department complaining that her abdomen had been continuously growing for the past 2 *** careful examinations,she was suspected of having a very large *** was also diagnosed with erythrocytosis because her RBC count was 6.49×10^(12)/L,hemoglobin was 197 g/*** a multidisciplinary team consultation,bilateral ureteral stents were placed,and 800 m L blood was removed by *** patient then underwent hysterectomy and bilateral *** recovered well from the operation,and her hemoglobin level decreased sharply following the ***-molecular-weight heparin was administered daily to prevent postoperative *** was discharged from the hospital on the fourth postoperative *** months later,all her hematological parameters returned to *** analysis of the myoma revealed that it was a benign leiomyoma,with partial hyalinization,and strong positivity for erythropoietin in immunohistochemical staining suggested that erythropoietin may be responsible for the *** Erythropoietin ectopically produced from the myoma was responsible for the erythrocytosis in this patient.A multidisciplinary team is strongly recommended.

关键词： Myomatous erythrocytosis syndrome erythrocytosis Uterine myoma Erythropoietin Multiple disciplinary team Case report

Relative Monocytosis in Patients with erythrocytosis

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Open Journal of Blood Diseases 2013年第1期3卷 21-24页

作者： Hiroshi Fujita Akira Ohwada Naoko Handa Shigeko Nishimura Department of Internal Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan. Department of Transfusion Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan

Polycythemia vera (PV) is characterized by leukocytosis, thrombocytosis, and low mean capsular volume (MCV). No specific hematological findings are observed in patients with erythrocytosis of other origins. However, recombinant erythropoietin (EPO) increases the number of mononuclear cells in the peripheral blood. Therefore, we hematologically examined monocytes in patients with erythrocytosis. The medical records of 48 erythrocytosis patients (hemoglobin: men, >18.5 g/dL;women, >16.5 g/dL) collected between August 2005 and July 2012 were reviewed for age, gender, hematology, and serum erythropoietin level. Patients were divided into 3 groups: PV (N = 17), reactive erythrocytosis (RE, N = 25), and EPO-elevated erythrocytosis (EPO-E, N = 6). We compared monocytes in the hemogram among the 3 groups and examined the correlation between hematological data and serum EPO level. The percent monocytes in the hemogram were 3.4% ± 0.3%, 7.4% ± 0.4%, and 12.3% ± 1.1% for the PV, RE, and EPO-E groups, respectively, which were significant (p 1.0 ′ 109/L) in the PV, RE, and EPO-E groups, respectively. A significant correlation was observed between percent monocyte or absolute monocyte count and serum EPO level. In conclusion, monocyte count in hemograms may be useful for diagnosing EPO-elevated erythrocytosis.

关键词： Erythropoietin Monocyte erythrocytosis

Anesthetic management of a child with double outlet right ventricle and severe polycythemia: A case report

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World Journal of Clinical Cases 2021年第11期9卷 2634-2640页

作者： Ling-Can Tan Wei-Yi Zhang Yi-Ding Zuo Hong-Yang Chen Chun-Ling Jiang Department of Anesthesiology West China HospitalSichuan University and The Research Units of West China(2018RU012)Chinese Academy of Medical SciencesChengdu 610041Sichuan ProvinceChina

BACKGROUND Double outlet right ventricle(DORV)is a rare and complex congenital heart defect,and the surgical repairs vary with type and pathophysiology *** to prolonged progressive hypoxemia,severe polycythemia is common in patients with DORV,which ultimately leads to coagulation dysfunction and increases the risk of thrombosis and ***,the anesthetic management is challenging and how to manage severe polycythemia and avoid hypoxia-related complications in such patients is of great *** SUMMARY Herein,we report the anesthetic management of a 10-year-old female patient with a *** lived in the low-oxygen Qinghai-Tibet Plateau,and presented with severe polycythemia(hemoglobin,24.8 g/dL;hematocrit,75%).She underwent a modified Fontan surgery,which was satisfactory and without any perioperative *** anesthetic management highlights the importance of perioperative hemodilution in decreasing the risk of thromboembolism and the importance of correcting coagulopathy in preventing *** Anesthetic management is challenging in rare cyanotic congenital heart disease patients with severe *** is important to adopt perioperative hemodilution and correction of coagulopathy in preventing thrombosis and hemorrhage.

关键词： Cyanotic congenital heart diseases Double outlet right ventricle Modified Fontan surgery Anesthesia erythrocytosis Case report

Laparoscopic hysterectomy as optimal approach for 5400 grams uterus with associated polycythemia: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3027-3032页

作者： Antonio Macciò Giacomo Chiappe Fabrizio Lavra Elisabetta Sanna Romualdo Nieddu Clelia Madeddu Department of Gynecologic Oncology Azienda Ospedaliera BrotzuCagliari 09100Italy Department of Medical Sciences and Public Health Medical Oncology UnitUniversity of CagliariCagliari 09042Italy

BACKGROUND Uterine myomas are the most common benign gynecological soft tissue tumors in women but polycythemia associated with these tumors is *** is significantly associated with risk of venous thromboembolism(VTE),which is further increased in case of a large pelvic mass and *** we report the surgical challenges in the case of an obese patient with a giant fibromatous uterus and associated *** SUMMARY A 42-year-old obese woman was referred to our department for treatment for a huge fibromatous *** suffered of pelvic pressure and abdominal distension and reported severe dyspnea from several *** analyses including hemoglobin(Hb)19.2 g/dL and hematocrit(Hct)59.7%were indicative of *** blood gas analysis showed arterial oxygen pressure(pO2)of 81.5 *** computed tomography confirmed a giant fibromatous uterus measuring 28.2 cm×17 cm×25 *** reduce the thromboembolic risk,the patient underwent low molecular weight heparin,phlebotomy twice before surgery,and we opted for a laparoscopic *** uterus weighed 5400 g and the histology confirmed a diagnosis of *** did not find increased erythropoietin levels in the supernatant of the myomatous uterine *** were no *** postoperative day 1,the Hb and the Hct levels normalized to 13.3 g/dL and 41.7%,*** blood gas analysis after surgery showed a pO2 of 144.7 *** results suggested the diagnosis of myomatous erythrocytosis *** patient was discharged on the second postoperative day in very good condition with no *** We believe this is the first reported laparoscopic hysterectomy in a patient with a giant uterus,polycythemia and *** VTE risk factors warranted a laparoscopic approach.

关键词： Hysterectomy Laparoscopy Myoma Myomatous erythrocytosis syndrome Polycythemia,huge uterus Total laparoscopic hysterectomy Case report