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Regulations of m6A and other RNA modifications and their roles in cancer

FRONTIERS OF MEDICINE 2024年第4期18卷 622-648页

作者： Chen, Xin-Hui Guo, Kun-Xiong Li, Jing Xu, Shu-Hui Zhu, Huifang Yan, Guang-Rong Guangzhou Med Univ Biomed Res Ctr Guangdong Prov Clin Res Ctr Obstet & Gynecol Guangdong Prov Key Lab Major Obstet DisState Key Guangzhou 510150 Peoples R China

RNA modification is an essential component of the epitranscriptome, regulating RNA metabolism and cellular functions. Several types of RNA modifications have been identified to date; they include N-6-methyladenosine (m(6)A), N-1-methyladenosine (m(1)A), 5-methylcytosine (m(5)C), N-7-methylguanosine (m(7)G), N-6,2 '-O-dimethyladenosine (m(6)A(m)), N-4-acetylcytidine (ac(4)C), etc. RNA modifications, mediated by regulators including writers, erasers, and readers, are associated with carcinogenesis, tumor microenvironment, metabolic reprogramming, immunosuppression, immunotherapy, chemotherapy, etc. A novel perspective indicates that regulatory subunits and post-translational modifications (PTMs) are involved in the regulation of writer, eraser, and reader functions in mediating RNA modifications, tumorigenesis, and anticancer therapy. In this review, we summarize the advances made in the knowledge of different RNA modifications (especially m(6)A) and focus on RNA modification regulators with functions modulated by a series of factors in cancer, including regulatory subunits (proteins, noncoding RNA or peptides encoded by long noncoding RNA) and PTMs (acetylation, SUMOylation, lactylation, phosphorylation, etc.). We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer progression. Additionally, inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关键词： RNA modification writers erasers readers regulatory subunits PTMs cancer MESSENGER-RNA RIBOSOMAL-RNA BINDING-PROTEIN NUCLEAR-RNA ONCOGENIC TRANSFORMATION THERAPEUTIC IMPLICATIONS FTO METHYLATION METHYLTRANSFERASE TRANSLATION

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The functions of N6-methyladenosine modification in lncRNAs

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Genes & Diseases 2020年第4期7卷 598-605页

作者： Rong-Zhang He Jing Jiang Di-Xian Luo Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangsha410078HunanChina Translational Medicine Institute National&Local Joint Engineering Laboratory for High-through Molecular Diagnosis TechnologyCollaborative Research Center for Post-doctoral Mobile Stations of Central South UniversityAffiliated the First People’s Hospital of ChenzhouUniversity of South ChinaChenzhou423000China Center for Clinical Pathology The First People’s Hospital of ChenzhouUniversity of South ChinaChenzhou423000People’s Republic of China

Increasing evidence indicates that mRNAs are often subject to posttranscriptional *** them,N6-methyladenosine(m6A),which has been shown to play key roles in RNA splicing,stability,nuclear export,and translation,is the most abundant modification of *** studies of m6A modification of mRNAs have been carried out,while little is known about m6A modification of long non-coding RNAs(lncRNAs).Recently,several studies reported m6A modification of *** this review,we focus on these m6A-modified lncRNAs and discuss possible functions of m6A modification.

关键词： erasers LncRNA N6-methyladenosine Readers Writers

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