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Spectral imaging technology of epithelial tissue based on two-photon excited fluorescence and second-harmonic generation

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Frontiers of Optoelectronics 2008年第Z1期1卷 33-38页

作者： Tianshu LUO Jianxin CHEN Shuangmu ZHUO Xingshan JIANG Huanglin CHEN Teng LUO Qilian ZOU Key Laboratory of Optoelectronics Science and Technology for Medicine Fujian Normal University Division of Cell Biology and Genetics Fujian Medical University

The layer structures of the esophageal and oral tissues were investigated by using spectral imaging technology based on two-photon excited fluorescence(TPEF) and second-harmonic generation(SHG). Because spectral imaging technology allows a simultaneous record of both the spectra and image, it is capable of identifying the layered structures of the epithelial tissues, including the keratinizing layer, epithelial cell layer and stromal layer in the molecular level, which are strongly correlated to tissue pathology. All this work indicates that this technique has the potential to provide more accurate and comprehensive information for the early pathological diagnosis of tissues with the stratified squamous epithelia.

关键词： spectral imaging epithelial tissue two-photon excited fluorescence (TPEF) second-harmonic generation (SHG)

DIAGNOSTIC APPLICATION OF MULTIPHOTON MICROSCOPY IN epithelial tissueS

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 159-163页

作者： XINGSHAN JIANG SHUANGMU ZHUO JIANXIN CHEN Institute of Laser and Optoelectronics Technology Fujian Provincial Key Laboratory for Photonics Technology Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Normal University Fuzhou 350007 China

epithelial cancer comprises more than 85%of human *** detection and treatment at the early stage has been demonstrated to apparently improve patient *** this review,we summarize our recent research works on the diagnostic application of epithelial tissue based on multiphoton microscopy(MPM),including identification of the layered structures of esophagus,oral cavity,skin and bronchus tissues,establishment of the diagnostic features for distinguishing gastric normal tissue from cancerous tissue,linking collagen alteration and ectocervical epithelial tumor progression for evaluating epithelial tumor progression,and differentiating normal,inflammatory,and dysplastic ectocervical epithelial *** results provide the groundwork for developing MPM into clinical multiphoton endoscopy.

关键词： epithelial tissue multiphoton microscopy two-photon excitedfluorescence secondharmonic generation

Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm

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Science China(Life Sciences) 2015年第5期58卷 432-441页

作者： ZHAN Jun YANG Mei ZHANG Jing GUO YongQing LIU Wei ZHANG HongQuan Key Laboratory of Carcinogenesis and Translational Research Ministry of Education State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center Laboratory of Molecular Cell Biology and Tumor Biology Department of Anatomy Histology and Embryology Peking University Health Science Center Department of Thoracic Surgery Sino-Japan Friendship Hospital Department of Immunology Third Military Medical University

Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Kindlin-1 tissue distribution and the dogma that governs Kindlin-1 expression in normal human body are elusive. This study examined Kindlin-1 expression in normal human adult organs, human and mouse embryonic organs by immunohistochemical analyses. We identified a general principle that the level of Kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues originate. We compared the expression of Kindlin-1 with Kindlin-2 and found that Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues. Likewise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse embryos. Our findings indicate that Kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues.

关键词： Kindlin- 1 epithelial tissue ectoderm endoderm embryo

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The role of extracellular calcium in the effect of a snake venom Lys49-phospholipase A_(2) on water transport across epithelial membranes

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Journal of Biophysical Chemistry 2011年第3期2卷 222-225页

作者： Renner de Souza Leite Wilson Franco Heloisa Sobreiro Selistre-de-Araujo Unidade Academica de Saude do Centro de Educacao e Saude Universidade Federal de Campina GrandeCuiteParaíbaBrazil Departamento de Ciencias Fisiologicas Universidade Federal de Sao CarlosSao CarlosBrazil

ACLMT is a Lys49-phospholipase A2 myotoxin isolated from the venom of the Agkistrodon contortrix laticinctus snake. This study investigated the mechanisms involved in effect of ACLMT on membrane water permeability by examining the role of extracellular calcium and strontium in this effect. Water flow across the membrane was gravimetrically measured in bladder sac preparations. The decrease in extracellular calcium promoted a higher response of epithelium to ACLMT, suggesting that the extracellular calcium protects the membrane from the action of the toxin. No alteration in the effect of the toxin on water transport was observed when calcium was replaced by strontium, indicating that this effect is independent of its enzymatic activity. These findings may bring an important contribution towards the comprehension of the mechanisms involved in the effect of Lys49-phospholipase A2 myotoxins on water permeability of epithelial membranes, with implications for the understanding of renal toxicity.

关键词： epithelial tissue Membrane Permeability Myotoxin Lys49-Phospholipase A_(2) Toad Bladder Water Transport

Kindler syndrome protein kindlin-1 is mainly expressed in adult tissues originated from ectoderm / endoderm

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中国民康医学 2015年第14期 145-145页

作者： ZHAN Jun YANG Mei ZHANG Jing GUO Yongqing LIU Wei ZHANG Hongquan Key Laboratory of Carcinogenesis and Translational Research Ministry of EducationPeking University Health Science Center State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center Laboratory of Molecular Cell Biology and Tumor Biology Department of AnatomyHistology and Embryology Department of Thoracic Surgery Sino - Japan Friendship Hospital Department of Immunology Third Military Medical University

Mutations of integrin-interacting protein Kindlin-1 cause Kindler Syndrome and deregulation of Kindlin-1 is implicated in human *** Kindlin-1-related diseases are confined in limited tissue ***,Kindlin-1 tissue distribution and the dogma that governs Kindlin-1 expression in normal human body are *** study examined Kindlin-1 expression in normal human adult organs,human and mouse embryonic organs by immunohistochemical *** identified a general principle that the level of Kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues are *** compared the expression of Kindlin-1 with Kindlin-2 and found that Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm,whereas Kindlin-2 is mainly expressed in mesoderm-derived ***,Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse *** findings indicate that Kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues.

关键词： Kindlin-1 epithelial tissue Ectoderm Endoderm Embryo