检索结果-南通市图书馆

Numerical study of dynamic zigzag patterns in migrating epithelial tissue

Science China(Physics,Mechanics & Astronomy) 2022年第1期65卷 45-52页

作者： Li-bing Cai Wenjie Ji Jie Luo Qun-li Lei Yu-qiang Ma National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China School of Physical Science and Technology Soochow UniversitySuzhou 215006China

Collective cell migration plays a crucial role in embryonic development, metastasis, and wound healing. Nevertheless, to the best of our knowledge, how the coordination between the cell motility and deformations affects the collective motion of epithelial cells is not fully understood. In this work, we propose a modified self-propelled Voronoi model for epithelial cell migration incorporating the coupling between the self-propulsion of cells and the polarization of the cell elongation. At a high coupling strength,we observe the emergence of backward traveling band structures formed by highly aligned cells, which can be regulated by cell elongations or shape anisotropy. Increasing the cell shape anisotropy, we find that large bands split into multiple small microbands. The latter essentially forms a dynamic zigzag pattern, in which the angle between the polarization direction of the bands and the migration direction switches alternatively between π/4 and-π/4 because the cells are forced to move preferentially in the anterior direction. We also analyzed the disclinations in the cell monolayer, force distribution near the domain boundaries and the shape alignment of the epithelial monolayer during the formation of this dynamic pattern. The present findings may further our understanding of stripe pattern formations in living systems and inspire potential designs for cell sorting.

关键词： epithelial tissue collective motion self-propelled Voronoi model zigzag pattern band

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DIAGNOSTIC APPLICATION OF MULTIPHOTON MICROSCOPY IN epithelial tissueS

引用

Journal of Innovative Optical Health Sciences 2011年第2期4卷 159-163页

作者： XINGSHAN JIANG SHUANGMU ZHUO JIANXIN CHEN Institute of Laser and Optoelectronics Technology Fujian Provincial Key Laboratory for Photonics Technology Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Normal University Fuzhou 350007 China

epithelial cancer comprises more than 85%of human cancers.The detection and treatment at the early stage has been demonstrated to apparently improve patient survival.In this review,we summarize our recent research works on the diagnostic application of epithelial tissue based on multiphoton microscopy(MPM),including identification of the layered structures of esophagus,oral cavity,skin and bronchus tissues,establishment of the diagnostic features for distinguishing gastric normal tissue from cancerous tissue,linking collagen alteration and ectocervical epithelial tumor progression for evaluating epithelial tumor progression,and differentiating normal,inflammatory,and dysplastic ectocervical epithelial tissues.These results provide the groundwork for developing MPM into clinical multiphoton endoscopy.

关键词： epithelial tissue multiphoton microscopy two-photon excitedfluorescence secondharmonic generation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of extracellular calcium in the effect of a snake venom Lys49-phospholipase A_(2) on water transport across epithelial membranes

引用

Journal of Biophysical Chemistry 2011年第3期2卷 222-225页

作者： Renner de Souza Leite Wilson Franco Heloisa Sobreiro Selistre-de-Araujo Unidade Academica de Saude do Centro de Educacao e Saude Universidade Federal de Campina GrandeCuiteParaíbaBrazil Departamento de Ciencias Fisiologicas Universidade Federal de Sao CarlosSao CarlosBrazil

ACLMT is a Lys49-phospholipase A2 myotoxin isolated from the venom of the Agkistrodon contortrix laticinctus snake. This study investigated the mechanisms involved in effect of ACLMT on membrane water permeability by examining the role of extracellular calcium and strontium in this effect. Water flow across the membrane was gravimetrically measured in bladder sac preparations. The decrease in extracellular calcium promoted a higher response of epithelium to ACLMT, suggesting that the extracellular calcium protects the membrane from the action of the toxin. No alteration in the effect of the toxin on water transport was observed when calcium was replaced by strontium, indicating that this effect is independent of its enzymatic activity. These findings may bring an important contribution towards the comprehension of the mechanisms involved in the effect of Lys49-phospholipase A2 myotoxins on water permeability of epithelial membranes, with implications for the understanding of renal toxicity.

关键词： epithelial tissue Membrane Permeability Myotoxin Lys49-Phospholipase A_(2) Toad Bladder Water Transport

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kindler syndrome protein kindlin-1 is mainly expressed in adult tissues originated from ectoderm / endoderm

引用

中国民康医学 2015年第14期 145-145页

作者： ZHAN Jun YANG Mei ZHANG Jing GUO Yongqing LIU Wei ZHANG Hongquan Key Laboratory of Carcinogenesis and Translational Research Ministry of EducationPeking University Health Science Center State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center Laboratory of Molecular Cell Biology and Tumor Biology Department of AnatomyHistology and Embryology Department of Thoracic Surgery Sino - Japan Friendship Hospital Department of Immunology Third Military Medical University

Mutations of integrin-interacting protein Kindlin-1 cause Kindler Syndrome and deregulation of Kindlin-1 is implicated in human cancers.The Kindlin-1-related diseases are confined in limited tissue types.However,Kindlin-1 tissue distribution and the dogma that governs Kindlin-1 expression in normal human body are elusive.This study examined Kindlin-1 expression in normal human adult organs,human and mouse embryonic organs by immunohistochemical analyses.We identified a general principle that the level of Kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues are originated.We compared the expression of Kindlin-1 with Kindlin-2 and found that Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm,whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues.Likewise,Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse embryos.Our findings indicate that Kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues.

关键词： Kindlin-1 epithelial tissue Ectoderm Endoderm Embryo

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：