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Regulation of TWlK-related potassium channel- 1 （Trek1） restitutes intestinal epithelial barrier function

Cellular & Molecular Immunology 2016年第1期13卷 110-118页

作者： Huang Huang Jiang-Qi Liu Yong Yu Li-Hua Mo Rong-Ti Ge Huan-Ping Zhang Zhi-Gang Liu Peng-Yuan Zheng Ping-Chang Yang Department of Gastroenterology the Second Hospital Zhengzhou University Zhengzhou China ENT Institute Shenzhen Key Laboratory of Allergy & Immunology Shenzhen University Shenzhen China ENT Hospital Longgang Central Hospital Shenzhen China Brain Body Institute McMaster University Hamilton ON Canada

The disruption of epithelial barrier integrity is an important factor in the pathogenesis of various immune disorders. However, the restitution of the compromised barrier functions is difficult. This study investigates the regulation of TWIK-related potassium channel-1 （Trek1） in the restitution of intestinal epithelial barrier functions. The human colon epithelial cell line T84 was cultured in monolayers and used to observe epithelial barrier functions in vitro. An intestinal allergy mouse model was created. Cytokine levels were determined by enzyme-linked immunosorbent assay and western blotting. The results showed that Trek1 deficiency induced T84 monolayer barrier disruption. Allergic responses markedly suppressed the expression of Trek1 in the intestinal epithelia via activating the mitogen-activated protein kinase pathways and increasing the expression of histone deacetylase-1. The inhibition of histone deacetylase-1 by sodium butyrate or the administration of a butyrate-producing probiotic （Clostridium butyricum） restored the intestinal epithelial barrier functions and markedly enhanced the effect of antigen-specific immunotherapy. The data suggest that Trek1 is required for the maintenance of intestinal epithelial barrier integrity. Allergic responses induce an insufficiency of Trek1 expression in the intestinal epithelia. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment.

关键词： allergy epithelial barrier, intestine probiotics Trek1

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