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eosinophilia complicated with venous thromboembolism:A case report

World Journal of Clinical Cases 2022年第6期10卷 1952-1960页

作者： Wei-Qiang Su Yan-Zhong Fu Shu-Yan Liu Meng-Jie Cao Ya-Bin Xue Fei-Fei Suo Wen-Chao Liu Department of Vascular Surgery The Second People’s Hospital of Jiaozuo CityJiaozuo 454000Henan ProvinceChina Department of Endocrine The Second People’s Hospital of Jiaozuo CityJiaozuo 454000Henan ProvinceChina Department of Neurology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Clinical Laboratory The Second People’s Hospital of Jiaozuo CityJiaozuo 454000Henan ProvinceChina

BACKGROUND eosinophilia is an increase of more than 0.5×109/L in the number of eosinophils;it is a systemic condition with an unknown etiology and is often accompanied by multiple impaired organ *** clinical manifestations of the disease are highly variable and diverse,rendering identification of the diagnosis challenging;hence,diagnosis and treatment are often *** few reports of this disease exist globally,especially with rare manifestations of cerebral venous sinus thrombosis and *** SUMMARY A 32-year-old woman with eosinophilia presented to the hospital with bilateral lower-limb edema as the first clinical manifestation,followed by an extensive maculopapular rash throughout the *** subsequently developed cerebral venous sinus thrombosis along with bilateral lower-limb deep vein *** weeks earlier,she had received a single course of antibiotics from a local hospital for a low-grade fever and sore *** various treatments were administered for anticoagulation,maintaining blood circulation,and relieving blood stasis,the lower extremity edema improved significantly;however,the patient’s eosinophil count gradually *** experienced cerebral venous sinus thrombosis,cerebral hemorrhage,and deep vein thrombosis of the lower limbs before being declared brain *** this case report,we have elaborated the diagnosis and management of deep vein thrombosis manifested as eosinophilia,thrombocytopenia,and elevated D-dimer *** Because proper diagnosis is challenging,clinical vigilance is required for patients with eosinophilia,as it can lead to thrombus formation.

关键词： eosinophilia Venous thromboembolism Diagnosis Management Venous thrombosis Case report

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Myeloid neoplasm with eosinophilia and rearrangement of plateletderived growth factor receptor beta gene in children: Two case reports

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World Journal of Clinical Cases 2021年第1期9卷 204-210页

作者： Shi-Chong Wang Wen-Yu Yang State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

BACKGROUND Myeloid neoplasm(MN)with eosinophilia and rearrangement of platelet-derived growth factor receptor beta(PDGFRB)shows a good therapeutic response to imatinib in *** is rarely found in children,and the efficacy of imatinib on pediatric patients remain *** SUMMARY We report 2 pediatric cases diagnosed with MN with eosinophilia and PDGFRB rearrangement who were treated with *** 1 was a 1-year-old girl admitted to the hospital because of“abdominal distension with hyperleukocytosis for 3 mo”.She had leukocytosis,anemia,and eosinophilia(the absolute eosinophil count(AEC)was 8960/μL),and her fluorescence in situ hybridization(FISH)test revealed that PDGFRB rearrangement was detected in 70%of 500 interphase *** 2 was a 2-year-old girl admitted to the hospital because of“recurrent fever and rashes for 1 mo”.Her blood cell count showed an AEC of 3540/μ*** FISH test revealed that PDGFRB rearrangement was detected in 71%of 500 interphase *** patients were diagnosed as MN with eosinophilia and PDGFRB *** was added into their treatment *** expected,complete hematologic remission was achieved after 1 mo of treatment,and symptoms *** Although MN with eosinophilia and PDGFRB rearrangement usually occurs in adults,it can be found in *** therapeutic benefits of imatinib in these 2 pediatric patients were consistent with its reported effects in adult patients.

关键词： Myeloid neoplasm Platelet-derived growth factor receptor beta rearrangement eosinophilia Children Imatinib Case report

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Prevalence of latent eosinophilia among occupational gardeners at Babcock University,Nigeria

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Asian Pacific Journal of Tropical Biomedicine 2016年第6期6卷 511-515页

作者： Ayodele Olushola Ilesanmi Ginnikachi Jennifer Ekwe Rosemary Isioma Ilesanmi Damilola Temitope Ogundele Jacob Kehinde Akintunde Oluwasogo Adewole Olalubi Department of Medical Laboratory Science Babcock University Department of Medical Microbiology Olabisi Onabanjo University Department of Chemical Geological & Physical SciencesChemistry UnitKwara State University Drug Metabolism and Molecular Environmental Toxicology Unit Biochemistry OptionDepartment of Bioscience and BiotechnologyCollege of Pure and Applied SciencesKwara State University School of Allied Health & Environmental Sciences Department of Allied HealthPublic Health UnitKwara State University

Objective: To determine the level of eosinophils present in the blood and sputum samples, presumably as a result of continual occupational exposure to allergens while on duty, as gardeners at Babcock University, ***: Haemocytometer and Olympus microscope were utilized to estimate eosinophils population in 44 blood samples and 21 sputum samples ***: Relationship between the occurrence of eosinophil in blood and the exposure period among Babcock University gardeners had a positive correlation(r = + 0.08,t = 4.55, P < 0.05). It was found that blood eosinophil count in these workers correlated with the length of exposure ***: The nature and the gardening activities are not a risk factor that significantly affect eosinophil level but duration of exposure to allergens. However, all safety precautionary kits and wears should be enforced and embraced by the concerned occupational gardeners so as to avert and subvert its pre-disposing deleterious effect on them.

关键词： eosinophilia Occupational Exposure Gardeners Duration Allergens

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One case of eosinophilia caused by atorvastatin

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Chinese Medical Journal 2013年第20期126卷 3994-3995页

作者： Tang Rui Chen Shi Zhang Hong-yu Chinese Acad Med Sci Peking Union Med Coll Hosp Peking Union Med Coll Dept Allergy Beijing 100730 Peoples R China Chinese Acad Med Sci Peking Union Med Coll Hosp Peking Union Med Coll Dept EndocrinolMinist HlthKey Lab Endocrinol Beijing 100730 Peoples R China

Atorvastatin （trade name： Lipitor, Ptizer） is a common .medicine for hyperlipidemia, but eosinophilia causedby atorvastatin is a rare condition. The exclusion method was used to look for specific causes of eosinophilia. It requires a long-term follow-up and step by step confirmation. Switching to another statin may be one of the treatment options.

关键词： eosinophilia atorvastatin

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Asymptomatic eosinophilia due to enterobiasis in a child:A case report

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 34-35页

作者： Yann A.Meunier Brazilian Academy of Medicine Australasian College of Tropical Medicine Stanford Prevention Research Center

This paper reported the case of a 6-year old child who presented with an asymptomatic *** diagnosis of enterobiasis was established by a Graham anal scotch test and he was successfully treated with fluoromebendazole. ... 详细信息

关键词： Enterobiasis asymptomatic eosinophilia

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Dyspeptic disorders and eosinophilia due to ancylostomiasis:a case report

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Asian Pacific Journal of Tropical Medicine 2009年第1期2卷 76-77页

作者： Yann A.Meunier Stanford Prevention Center Hoover Pavilion211 Quarry Road StanfordCA94305-5705

We present the case of a 41-year old man who consulted for dyspeptic disorders and presented with eosinophilia after a trip to *** diagnosis of ancylostomiasis was made by a parasitological stool *** treatment by fluo... 详细信息

关键词： Ancylostomiasis Dyspeptic disorders eosinophilia Senegal

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Autoimmune hepatitis and eosinophilia:A rare case report

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World Journal of Hepatology 2023年第2期15卷 311-317页

作者： Isabel Garrido Susana Lopes Elsa Fonseca Fátima Carneiro Guilherme Macedo Department of Gastroenterology and Hepatology Centro Hospitalar Universitário de São JoãoWorld Gastroenterology Organization Porto Training CenterFaculty of Medicine of the University of PortoPortoPortugal Department of Pathology Centro Hospitalar Universitário de São JoãoInstituto de Investigação e Inovação em Saúde(i3S)and Institute of Molecular Pathology and ImmunologyUniversity of Porto(Ipatimup)Faculty of Medicine of the University of PortoPortoPortugal

BACKGROUND Autoimmune hepatitis consists of a chronic liver disease whose etiology is *** is comprised of relevant immunological aspects and of immunemediated liver *** may be a considerable feature,particularly happening in male *** SUMMARY We report here a Crohn´s disease patient presenting with de novo hypergammaglobulinemia,circulating autoantibodies and elevated transaminase *** also had significant peripheral eosinophilia and elevated immunoglobulin E levels at *** pathology findings from liver biopsy were compatible with autoimmune hepatitis with eosinophilic *** This is the first report of autoimmune hepatitis with exuberant eosinophilic infiltration in the liver and bone marrow,described in a patient with Crohn’s disease.

关键词： Autoimmune hepatitis eosinophilia Bone marrow Crohn’s disease Case report

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eosinophilia:Rare cause of arterial thrombosis and cardioembolic stroke in childhood

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World Journal of Cardiology 2012年第4期4卷 128-129页

作者： Sanjeev Kumar Sharma Suman Kumar Tulika Seth Pravas Mishra Manoranjan Mahapatra Department of Hematology All India Institute of Medical SciencesNew Delhi 110029India

eosinophilia has been reported as a very rare cause of stroke in *** thrombotic event may be either due to cardiac damage induced by eosinophils and their granular protein,that is,the major basic protein,or the systemic hypercoagulable state induced by *** report here a case of eosinophilia whose initial presentation was recurrent strokes and cardiac and arterial thrombosis.

关键词： eosinophilia Cardioembolic stroke Thrombosis Low molecular weight heparin Warfarin

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Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases

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World Journal of Gastroenterology 2004年第24期10卷 3643-3646页

作者： Sebnem Ustun Nevin Turgay Songul Bayram Delibas Hatice Ertabaklar Department of Gastroenterology School of MedicineUniversity of Ege35100 BornovaIzmirTurkey Department of Parasitology School of MedicineUniversity of Ege35100 BornovaIzmirTurkey Department of Parasitology School of MedicineUniversity of Dokuz EylulIzmirTurkey Department of Microbiology School of MedicineUniversity of Aydin MenderesAydinTurkey

AIM:Intestinal parasitic diseases are commonly accompanied with diarrhoeal symptoms and allergic *** occurs as a result of IL-5 synthesized from Th2 cells during allergic ***-5 acts as a factor activating eosinophils. The aim of this study was to compare the IL-5 cytokine measurements in serum samples and cell *** also to compare eosinophilia observed in helminth infections and protozoon infections accompanied with allergy. METHODS:Twenty-three patients who presented with diarrhoeal symptoms and allergic complaints were tested positive for intestinal parasites,as well as 21 controls with allergic complaints who did not have any intestinal parasites were included in this ***-5 production in in vitro cell cultures prepared by using phytohemaglutinin (PHA) to stimulate peripheral blood mononuclear cells (PBMC) obtained from the blood samples taken from these patients were compared with the IL-5 level in ***, the IL-5 production in protozoon and helminth infections was also *** eosinophil values in 1 mm^3 of blood were calculated by means of peripheral smear in both groups within the scope of the study. RESULTS:Parasites such as helminth detected in 15 (65.2%) and protozoon in 8 (34.8%) of the patients were included in this *** regards the values of the sera in both patients with parasite infection and controls,the IL-5 production was found to be higher in the cell culture supernatant (P0.05). CONCLUSION:It was found that IL-5 cyto

关键词： Adult Cells, Cultured Diarrhea eosinophilia Female Helminthiasis Humans Hypersensitivity Interleukin-5 Male Middle Aged Protozoan Infections Th2 Cells

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Phenytoin Induced Drug Reaction with eosinophilia and Systemic Symptoms (DRESS): Case Report

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Case Reports in Clinical Medicine 2020年第11期9卷 343-353页

作者： Maria Noel Marzano Rodrigues Julia Arriada Cabreira Rony Kafer Nobre Medicine School Catholic University of Pelotas Pelotas Brazil

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening condition. It presents a long prodromal period, extensive rash, fever, lymphadenopathy, hematologic abnormalities (eosinophilia with or without atypical lymphocytosis), and internal organ involvement. Purpose: To describe a case of phenytoin induced DRESS syndrome, presenting diagnostic and management challenges of clinical interest. Methods: The Consensus-based Clinical Case Reporting Guideline Development (CARE) was observed for data analysis in case reports. Case Report: A 22-year-old man, using phenytoin for 60 days, sought medical attention due to fever and maculopapular cutaneous lesions. He presented lymphocytosis with eosinophilia and severe acute hepatitis 24 hours after admission day. Hepatic transaminases returned to reference levels after phenytoin withdrawal, and eosinophilia and cutaneous manifestations did not respond well to systemic steroids. A forearm biopsy showed findings suggestive of severe cutaneous adverse reaction. The patient’s microscopic and clinical characteristics meet all criteria in the scoring systems of Bocquet et al., Registry of Severe Cutaneous Adverse Reaction (RegiSCAR), and Japanese Research Committee on Severe Cutaneous Adverse Reaction (J-SCAR), being highly suggestive of DRESS syndrome very probably caused by phenytoin. The complete remission of symptoms was achieved weeks after admission. Conclusions: DRESS syndrome is a defiant reaction. Clinicians must be aware of potential causative drugs and perform a complete clinical examination using the available resources, including laboratory tests and histopathological assessment. The clinical remission relies on the withdrawal of the culprit drug. Particular attention should be given to the involvement of internal organs.

关键词： Drug Hypersensitivity Syndrome eosinophilia Anticonvulsants

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