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Enriched environment upregulates growth-associated protein 43 expression in the hippocampus and enhances cognitive abilities in prenatally stressed rat offspring

引用

Neural Regeneration Research 2012年第25期7卷 1967-1973页

作者： Zhengyu Zhang Hua Zhang Baoling Du Zhiqiang Chen Department ofHistologyand Embryology Guangzhou Medical University Guangzhou 510185 Guangdong Province China Department of Stomatology First Affiliated Hospital Jinan University Guangzhou 510630 Guangdong Province China Department of Orthopedics Surgery Liaocheng People's Hospital Liaocheng 252000 Shandong Province China

In our previous study, we reported that prenatal restraint stress could induce cognitive deficits, which correlated with a change in expression of growth-associated protein 43 in the hippocampus. In this study, we investigated the effects of enriched environment on cognitive abilities in prenatally stressed rat offspring, as well as the underlying mechanisms. Reverse transcription-PCR and western blot assay results revealed that growth-associated protein 43 mRNA and protein levels were upregulated on postnatal day 15 in the prenatal restraint stress group. Growth-associated protein 43 expression was significantly lower in the prenatal restraint stress group compared with the negative control and prenatal restraint stress plus enriched environment groups on postnatal days 30 and 50. Morris water maze test demonstrated that cognitive abilities were noticeably increased in rats from the prenatal restraint stress plus enriched environment group on postnatal day 50. These results indicate that enriched environment can improve the spatial learning and memory ability of prenatally stressed offspring by upregulating growth-associated protein 43 expression.

关键词： prenatal restraint stress growth-associated protein 43 hippocampus Morris water maze enrichedenvironment cognition neural regeneration

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