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Distribution and characteristics of telocytes as nurse cells in the architectural organization of engineered heart tissues

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Science China(Life Sciences) 2014年第2期57卷 241-247页

作者： ZHOU Jin WANG Yan ZHU Ping SUN HongYu MOU YongChao DUAN CuiMi YAO AnNing LV ShuangHong WANG ChangYong Department of Advanced Interdisciplinary Studies Institute of Basic Medical Sciences and Tissue Engineering Research CenterAcademy of Military Medical Sciences The First Department of Cardiology South Building The General Hospital of People's Liberation Army Laboratory of Oncology Affiliated Hospital of Academy of Military Medical Sciences

Interstitial Cajal-like cells are a distinct type of interstitial cell with a wide distribution in mammalian organs and tissues,and have been given the name"telocytes".Recent studies have demonstrated the potential roles of telocytes in heart development,renewal,and ***,further research on the functions of telocytes is limited by the complicated in vivo *** study was designed to construct engineered heart tissue(EHT)as a three-dimensional model in vitro to better understand the role of telocytes in the architectural organization of the *** were constructed by seeding neonatal cardiomyocytes in collagen/Matrigel scaffolds followed by culture under persistent static *** in EHTs were identified by histology,toluidine blue staining,immunofluorescence,and transmission electron *** results from histology and toluidine blue staining demonstrated widespread putative telocytes with compact toluidine blue-stained nuclei,which were located around *** from the cell bodies showed a characteristic dichotomous branching pattern and formed networks in *** revealed positive staining of telocytes for CD34 and vimentin with typical moniliform prolongations.A series of electron microscopy images further showed that typical telocytes embraced the cardiomyocytes with their long prolongations and exhibited a marked appearance of nursing cardiomyocytes during the construction of *** finding highlights the great importance of telocytes in the architectural organization of *** also suggests that EHT is an appropriate physical and pathological model system in vitro to study the roles of telocytes during heart development and regeneration.

关键词： telocytes collagen/matrigel scaffolds engineered heart tissues reconstruction

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