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Aluminum and Glyphosate Can Synergistically Induce Pineal Gland Pathology: Connection to Gut Dysbiosis and Neurological Disease

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Agricultural Sciences 2015年第1期6卷 42-70页

作者： Stephanie Seneff Nancy Swanson Chen Li Computer Science and Artificial Intelligence Laboratory MIT Cambridge MA USA Independent Researcher Abacus Enterprises Lummi Island WA USA

Many neurological diseases, including autism, depression, dementia, anxiety disorder and Parkinson’s disease, are associated with abnormal sleep patterns, which are directly linked to pineal gland dysfunction. The pineal gland is highly susceptible to environmental toxicants. Two pervasive substances in modern industrialized nations are aluminum and glyphosate, the active ingredient in the herbicide, Roundup?. In this paper, we show how these two toxicants work synergistically to induce neurological damage. Glyphosate disrupts gut bacteria, leading to an overgrowth of Clostridium difficile. Its toxic product, p-cresol, is linked to autism in both human and mouse models. p-Cresol enhances uptake of aluminum via transferrin. Anemia, a result of both aluminum disruption of heme and impaired heme synthesis by glyphosate, leads to hypoxia, which induces increased pineal gland transferrin synthesis. Premature birth is associated with hypoxic stress and with substantial increased risk to the subsequent development of autism, linking hypoxia to autism. Glyphosate chelates aluminum, allowing ingested aluminum to bypass the gut barrier. This leads to anemia-induced hypoxia, promoting neurotoxicity and damaging the pineal gland. Both glyphosate and aluminum disrupt cytochrome P450 enzymes, which are involved in melatonin metabolism. Furthermore, melatonin is derived from tryptophan, whose synthesis in plants and microbes is blocked by glyphosate. We also demonstrate a plausible role for vitamin D3 dysbiosis in impaired gut function and impaired serotonin synthesis. This paper proposes that impaired sulfate supply to the brain mediates the damage induced by the synergistic action of aluminum and glyphosate on the pineal gland and related midbrain nuclei.

关键词： Pineal Gland Aluminum Glyphosate Genetically engineered Crops Autism Sulfate

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Advances in homology directed genetic engineering of human pluripotent and adult stem cells

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World Journal of Stem Cells 2013年第4期5卷 98-105页

作者： Kalpith Ramamoorthi Donald Curtis Prashanth Asuri Department of Bioengineering Santa Clara University

The ability to introduce precise genomic modifications in human cells has profound implications for both basic and applied research in stem cells, ranging from identification of genes regulating stem cell self-renewal and multilineage differentiation to therapeutic gene correction and creation of in vitro models of human diseases. However, the overall efficiency of this process is challenged by several factors including inefficient gene delivery into stem cells and low rates of homology directed site-specific targeting. Recent studies report the development of novel techniques to improve gene targeting efficiencies in human stem cells; these methods include molecular engineering of viral vectors to efficiently deliver episomal genetic sequences that can participate in homology directed targeting, as well as the design of synthetic proteins that can introduce double-stranded breaks in DNA to initiate such recombination events. This review focuses on the potential of these new technologies to precisely alter the human stem cell genome and also highlights the possibilities offered by the combination of these complementary strategies.

关键词： Human stem cells Genetic engineering engineered viruses Synthetic restriction endonucleases

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Training stem cells for treatment of malignant brain tumors

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World Journal of Stem Cells 2014年第4期6卷 432-440页

作者： Shengwen Calvin Li Mustafa H Kabeer Long T Vu Vic Keschrumrus Hong Zhen Yin Brent A Dethlefs Jiang F Zhong John H Weiss William G Loudon Neuro-On-cology and Stem Cell Research Laboratory Center for Neurosci-ence ResearchChildren’s Hospital of Orange CountyUniversity of California-IrvineOrangeCA 92868United States Department of Neurology University of California IrvineOrangeCA 92862United States Department of Pathology University of Southern CaliforniaLos AngelesCA 90033United States

The treatment of malignant brain tumors remains a challenge. Stem cell technology has been applied in the treatment of brain tumors largely because of the ability of some stem cells to infiltrate into regions within the brain where tumor cells migrate as shown in preclinical studies. However, not all of these efforts can translate in the effective treatment that improves the quality of life for pa-tients. Here, we perform a literature review to identify the problems in the field. Given the lack of efficacy of most stem cell-based agents used in the treatment of malignant brain tumors, we found that stem cell distribution(i.e., only a fraction of stem cells applied capable of targeting tumors) are among the limiting factors. We provide guidelines for potential improvements in stem cell distribution. Specifically, we use an engineered tissue graft platform that replicates the in vivo microenvironment, and provide our data to validate that this culture platform is viable for producing stem cells that have better stem cell distribution than with the Petri dish culture system.

关键词： Stem cells Malignant brain tumors engineered tissue graft Organotypic slice model

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New approaches to increase intestinal length: Methods used for intestinal regeneration and bioengineering

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World Journal of Transplantation 2016年第1期6卷 1-9页

作者： Ali Shirafkan Mauro Montalbano Joshua Mc Guire Cristiana Rastellini Luca Cicalese Texas Transplant Center Department of Surgery University of Texas Medical Branch

Inadequate absorptive surface area poses a great challenge to the patients suffering a variety of in-testinal diseases causing short bowel syndrome. To date, these patients are managed with total parenteral nutrition or intestinal transplantation. However, these carry significant morbidity and mortality. Currently, by emergence of tissue engineering, anticipations to utilize an alternative method to increase the intestinal absorptive surface area are increasing. In this paper, we will review the improvements made over time in attempting elongating the intestine with surgical techniques as well as using intestinal bioengineering. Performing sequential intestinal lengthening was the preliminary method applied in humans. However, these methods did not reach widespread use and has limited outcome. Subsequent experimental methods were developed utilizing scaffolds to regenerate intestinal tissue and organoids unit from the intestinal epithelium. Stem cells also have been studied and applied in all types of tissue engineering. Biomaterials were utilized as a structural support for naive cells to produce bio-engineered tissue that can achieve a near-normal anatomical structure. A promising novel approach is the elongation of the intestine with an acellular biologic scaffold to generate a neoformed intestinal tissue that showed, for the first time, evidence of absorption in vivo. In the large intestine, studies are more focused on regeneration and engineering of sphincters and will be briefly reviewed. From the review of the existing literature, it can be concluded that significant progress has been achieved in these experimental methods but that these now need to be fully translated into a pre-clinical and clinical experimentation to become a future viable therapeutic option.

关键词： Bioengineered intestine Tissue engineered Scaffolds Organoids Stem cells Intestinal elongation techniques

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PPG Introduces New Glass for Solar Market

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China Chemical Reporter 2009年第15期20卷 14-14页

PPG Industries has introducedSolarphire AR (anti-reflective)glass,a new product engineered to maximize solar energy transmission to solar-collection photovoltaic

关键词： photovoltaic Solar reflective maximize engineered

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基于超表面的新型微电子器件

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光电工程 2017年第3期44卷 254-254,377页

借助人工构建超表面,有望实现无半导体的微电子器件。由于现有微电子器件的性能受到其构成材料——自然半导体的限制,加州大学圣地亚哥分校Dan Sievenpiper教授领导的研究团队提出了基于光电子发射的器件,并且制造了第一个光控微电子器... 详细信息

借助人工构建超表面,有望实现无半导体的微电子器件。由于现有微电子器件的性能受到其构成材料——自然半导体的限制,加州大学圣地亚哥分校Dan Sievenpiper教授领导的研究团队提出了基于光电子发射的器件,并且制造了第一个光控微电子器件,该器件由人工构建超表面而不是半导体组成,该超表面由平行金条阵列上的金蘑菇状纳米结构阵列制成。当这种由超材料组成的微电子器件被低电压和低功率激光激活时,可以增加1000%的导电率,

关键词：微电子器件人工构建构成材料超材料蘑菇状导电率 California engineered innovative photovoltaic

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Ticona to Add 15 000 T/A Compounding Unit in Nanjing

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China Chemical Reporter 2008年第Z1期19卷 8-8页

Ticona,the engineering polymers business of Celanese Corporation,plans to expand its integrated Nanjing com-plex to include a compounding unit that will produceadvanced

关键词： Nanjing expand Jiangsu quarter engineered eastern

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嵌合抗原受体-T细胞治疗复发难治型急性淋巴细胞白血病的护理

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重庆医学 2016年第33期45卷 4742-4743页

作者：冯娜杜欣张诚郝静曾荔第三军医大学新桥医院血液科重庆400037

在临床上通过输注嵌合抗原受体-T细胞（chimeric antigen receptor-engineered T cells,CAR-T）来进行免疫治疗,首次通过基因改造技术应用慢性病毒载体,将表达B细胞的CD19＋特异性嵌合抗原受体转染至患者的T细胞中,改造后的T细胞称为CD1... 详细信息

在临床上通过输注嵌合抗原受体-T细胞（chimeric antigen receptor-engineered T cells,CAR-T）来进行免疫治疗,首次通过基因改造技术应用慢性病毒载体,将表达B细胞的CD19＋特异性嵌合抗原受体转染至患者的T细胞中,改造后的T细胞称为CD19特异性CAR-T细胞。CAR-T通过表面标志特异性识别、结合、杀伤CD19＋肿瘤细胞。可以用于临床B细胞白血病/淋巴瘤的治疗,CD19CAR-T细胞诱导CR率高,可以介导髓外抗肿瘤的作用。

关键词： T细胞抗原受体病毒载体转染特异性识别淋巴瘤免疫治疗 engineered 层流床层流病床

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COVER

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Virologica Sinica 2015年第6期30卷 400-400页

Phage display is a method for the study of protein-or peptide-biological molecule interactions that utilize bacteriophages to connect peptides with the genetic information that encodes *** filamentous bacteriophage M1... 详细信息

关键词： Phage utilize connect COVER details ferrous ferric phage engineered instruments

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分集接收、路由选择

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电子科技文摘 2003年第7期 54-56页

Y2002-63345-1566 0314699保证无环路的路由选择通信工程网络的恢复方法=Restoration methods for traffic engineered networks withloop-free rollting guarantee[会,英]/Rabbat,R.& Siu,K.-Y.∥2001 IEEE International Conference o... 详细信息

关键词：分集接收路由选择工程网络 guarantee traffic 迂回选路 engineered 多径路由分集技术 routing

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