检索结果-南通市图书馆

A global perspective in asthma： from phenotype to endotype

Chinese Medical Journal 2013年第1期126卷 166-174页

作者： Min Xie Sally E. Wenzel University of Pittsburgh Asthma Institute Division of PulmonaryAllergy and Critical Care Medicine Department of MedicineUniversity of Pittsburgh Pittsburgh PA 15213 USA Department of Respiratory and Critical Care Medicine TongjiHospital Tongji Medical College Huazhong University of Scienceand Technology Wuhan Hubei 430030 China

Asthma affects about 300 million people worldwide, placing an enormous strain on health resources inmany countries. Evidence is increasing that asthma is a complex condition with different underlying pathophysiologiesJ Scientists around the world have devoted much effort to unveiling this heterogeneity, from phenotyping initially focused on combinations of clinical characteristics, towards endotypes evolving which link pathophysiological mechanism to subtypes of asthma.2 The identification of these endotypes, either by matching biology, genetics and therapeutic responses with clinically defined phenotypes or through unbiased genomic approaches, remains limited.3 Moving forward, ongoing studies that expand on these insights into the molecular signatures should enhance our ability to define the endotypes and lead to more targeted approaches to asthma therapy.4

关键词： asthma phenotype endotype pathophysiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Precision medicine in sepsis and septic shock:From omics to clinical tools

引用

World Journal of Critical Care Medicine 2022年第1期11卷 1-21页

作者： Juan Carlos Ruiz-Rodriguez Erika P Plata-Menchaca Luis Chiscano-Camón Adolfo Ruiz-Sanmartin Marcos Pérez-Carrasco Clara Palmada Vicent Ribas Mónica Martínez-Gallo Manuel Hernández-González Juan J Gonzalez-Lopez Nieves Larrosa Ricard Ferrer Intensive Care Department Vall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Shock Organ Dysfunction and Resuscitation Research GroupVall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Departament de Medicina Universitat Autònoma de BarcelonaBellaterra 08193Spain Department of Intensive Care Hospital Clínic de BarcelonaBarcelona 08036Spain Data Analytics in Medicine Digital Health UnitEurecatCentre Tecnològic de CatalunyaBarcelona 08005Spain Immunology Division Vall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Diagnostic Immunology Research Group Vall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Department of Cell Biology Physiology and ImmunologyUniversitat Autònoma de BarcelonaBellaterra 08193Spain Department of Clinical Microbiology Vall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Department of Microbiology and Genetics Universitat Autònoma de BarcelonaBellaterra 08193Spain

Sepsis is a heterogeneous disease with variable clinical course and several clinical *** it is associated with an increased risk of death,patients with this condition are candidates for receipt of a very well-structured and protocolized *** patients should receive the fundamental pillars of sepsis management,which are infection control,initial resuscitation,and multiorgan ***,specific subgroups of patients may benefit from a personalized approach with interventions targeted towards specific pathophysiological ***,we will review the framework for identifying subpopulations of patients with sepsis,septic shock,and multiorgan dysfunction who may benefit from specific *** of these approaches are still in the early stages of research,while others are already in routine use in clinical practice,but together will help in the effective generation and safe implementation of precision medicine in sepsis.

关键词： Sepsis Septic shock Organ dysfunction Precision medicine Biomarkers Phenotype endotype

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：