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Pathophysiology of functional heartburn based on Rome Ⅲ criteria in Japanese patients

World Journal of Gastroenterology 2015年第16期21卷 5009-5016页

作者： Yasuhiro Tamura Yasushi Funaki Shinya Izawa Akihito Iida Yoshiharu Yamaguchi Kazunori Adachi Naotaka Ogasawara Makoto Sasaki Hiroshi Kaneko Kunio Kasugai Department of Gastroenterology Division of Internal MedicineAichi Medical University School of Medicine Department of Clinical Laboratory Aichi Medical University School of Medicine Department of Internal Medicine Hoshigaoka Maternity Hospital

AIM:To investigate the pathophysiology of functional heartburn(FH) in Japanese ***:A total of 111 patients with proton pump inhibitor(PPI)-refractory non-erosive gastroesophageal reflux disease underwent intraesophageal pressure testing and 24-h multichannel intraluminal impedancep H(24MII-p H) *** patients also completed several questionnaires while they were receiving the PPI treatment, including the questionnaire for the diagnosis of reflux disease(QUEST), the frequency scale for the symptoms of gastroesophageal reflux disease(FSSG), the gastrointestinal symptoms rating scale(GSRS), SF-36, and the Cornell Medical Index(CMI).The subjects were classified into FH and endoscopy-negative reflux disease(ENRD) groups based on the Rome Ⅲ ***:Thirty-three patients with esophageal motility disorder were excluded from this study, while 22 patients with abnormal esophageal acid exposure time(p H-POS) and 34 with hypersensitive esophagus(HE) were included in the ENRD *** FH group included 22 patients with no reflux ***, age, and body mass index did not differ significantly between the *** mean SF-36 values were < 50(normal) for all scales in these groups, with no significant *** GSRS scores in these groups were not different and showed overlap with other gastrointestinal *** QUEST and the FSSG scores did not differ significantly between the *** was diagnosed using the CMI questionnaire in 17 of the 78 included subjects within the p H-POS(n=4),HE(n=8),and FH(n=5)groups,with no significant ***:Clinical characteristics of the FH and PPI-refractory ENRD groups were ***,esophageal function should be examined via manometry and 24MII-p H testing to differentiate between them.

关键词： Functional heartburn endoscopy-negativereflux disease proton pump inhibitor-resistant RomeⅢ criteria 24-h multichannel intraluminal impedancepHtesting

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