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Reversibly sensitizing-storing-releasing ^(1)O_(2) within a single platinum(Ⅱ)-acetylide-based metallacycle molecule via laser power modulation

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Science China Chemistry 2024年第2期67卷 604-611页

作者： Ruyi Zhou Wen Lv Bo Li Bo Yu Sudi Zhang Yucheng Zhou Shujuan Liu Qiang Zhao State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology)Nanjing University of Posts and Telecommunications(NUPT)Nanjing210023China College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and DevicesNanjing University of Posts and Telecommunications(NUPT)Nanjing210023China

Tumor hypoxia severely limits the therapeutic efficacy of photodynamic therapy(PDT) for solid tumors,which is highly dependent on tissue oxygen *** this study,we developed a platinum(Ⅱ)-acetylide-based metallacycle compound bearing six 1,4-dimethylnaphthalenes(DMN) groups,and controlled the photodynamic and photothermal effects of the compound by adjusting the power of 730 nm laser to achieve reversible sensitization,storage and release of 1~O_(2) within a single *** compound formed nanoparticles by self-assembly and exhibited good water solubility and *** laser irradiation,the strong spin-orbit coupling of platinum atoms in the metallacycle facilitated 1~O_(2) *** produced 1~O_(2) was captured by the DMN carriers and transported into the hypoxic tumor,where 1~O_(2) release was triggered owing to the good photothermal effect of the extended conjugation of the *** therapy,the metallacycle serving as a photosensitizer,1~O_(2) carrier,and photothermal reagent,achieved the synergistic therapy of PDT/PTT,demonstrating the versatility of the *** study proposes a new strategy to develop phototherapy agents that are suitable for hypoxic tumors.

关键词： metallacycles singlet oxygen endoperoxides near-infrared absorption synergistic treatment

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A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal-Organic Framework for Cancer Therapy

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CCS Chemistry 2021年第5期3卷 1187-1202页

作者： Bo-Ru Xie Chu-Xin Li Yun Yu Jin-Yue Zeng Ming-Kang Zhang Xiao-Shuang Wang Xuan Zeng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of Ministry of Education Department of ChemistryWuhan UniversityWuhan 430072

Here,a methacrylate-modified pyridone derivative(mPYR)was loaded into a porphyrin nanoscale metal-organic framework(porphyrin-nMOF).Then,the loaded mPYR was further polymerized to obtain poly-pyridone(poly-mPYR)to form poly-mPYR loaded porphyrin-nMOF,which is designated as PLP and used as a reservoir of singlet oxygen(^(1)O_(2)).It was found that PLP could quickly capture^(1)O_(2)in vitro and slowly release^(1)O_(2)in vivo to induce cancer cell *** release of^(1)O_(2)was light and oxygen independent,and the entire process did not cause intracellular oxygen *** also displayed good therapeutic effect in the treatment of both solid tumor and lung metastasis *** strategy of oxygenand light-independent^(1)O_(2)treatment presents great potential for treating refractory ***,the form of^(1)O_(2)capturing polymer-loaded nMOF expands the biomedical applications of MOFs and polymers,which can be used as a platform for biomedical applications.

关键词： cancer endoperoxides pyridone derivative metal-organic framework photodynamictherapy

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Benzothiazole-endoperoxide conjugates protect PC12 cells againstβ-amyloid-induced cell death via singlet oxygen mediated oxidative detoxification of fibrils

Smart Molecules

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Smart Molecules 2024年第2期2卷 111-118页

作者： Hao Wu Lei Wang Xiao Qian Wanwan Wang Yu Si Rensong Sun Engin U.Akkaya State Key Laboratory of Fine Chemicals and Department of Pharmaceutical ScienceSchool of Chemical EngineeringDalian University of TechnologyDalianChina Global Education Program for AgriScience Frontiers Graduate School of AgricultureHokkaido UniversitySapporoJapan

Metastable endoperoxides with beta-amyloid fibrils targeting benzothiazole moieties were designed and *** oxygen released from these endoperoxides by thermal cycloreversion reaction was shown to cause significant structural changes on the amyloid *** importantly,the cytotoxicity of the beta-amyloid fibrils on the PC12 cells were significantly reduced in the presence of *** observation,coupled with the fact that neither external oxygen,nor light is needed for this transformation,is very promising.

关键词： β-amyloid protein Alzheimer's disease benzothiazole endoperoxides singlet oxygen

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