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World Journal of Clinical Cases 2023年第6期11卷 1365-1371页

作者： Jian-Yang Feng Qing-Ping Jiang Hong He Department of Obstetrics and Gynecology Guangdong Provincial Key Laboratory of Major Obstetric DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Pathology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Endometriosis is a common gynecological disorder that affects women of reproductive *** is characterized by a cancer-like invasion of the extra-uterine endometrium and exhibits a strong association with ovarian clear cell cancer and endometrioid ***-associated fallopian tube endometrioid adenocarcinoma synchronized with endometrial adenocarcinoma was rarely *** SUMMARY A 49-year-old woman was referred to our hospital complaining about abnormal vaginal bleeding for three years following unsatisfactory ***-erative frozen sections unexpectedly unveiled an endometrioid cancer of the left fallopian tube with superficial invasion surrounded by diffuse endometriosis synchronized with endometrioid endometrial *** It was difficult to make a differential diagnosis when confronted with incidental findings of fallopian tube cancer lesions synchronized with endometrial *** key differential diagnosis of primary endometriosis-associated endometrioid adenocarcinoma of the fallopian tube from endometrial adenocarcinoma invol-vement relies on the pathological identification of malignant transformation in fallopian tube endometriosis disease.

关键词： Endometriosis-associated cancer Fallopian tube neoplasms endometrial neoplasms Case report

Correlation between single nucleotide polymorphisms of 17β-HSD-1 and endometrial adenocarcinoma

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现代妇产科进展 2011年第8期20卷 670-672页

作者： Qian Shao Zhang Hong Han Wenfei Jian Yan Fu Weijiang Yang Xingsheng Jinan Maternal and Infant Hospital Jinan 250001 Qilu Hospital of Shandong University

Objective: To investigate the correlation between 17-beta-hydroxysteroid dehydrogenase type1(17β-HSD-1) gene polymorphisms and risk of endometrial ***: Forty-one patients with endometrial adenocarcinoma were selected as experimen-tal group and twenty-seven healthy women were selected as control *** three common single nucleotide polymorphism of 17β-HSD-1 gene at sites + 1004,+ 1322 and + 1954 were detected by allele-specific PCR(ASA-PCR).The allele frequencies were analyzed by SPSS13.0 software between endometrial cancer cases and ***: We observed no significant difference in various frequency distribution between experimental group and control group.P1004= 0.994,P1322 = 0.974,and P1954 = ***: We found that three common SNPs with the 17β-HSD-1 gene were not associated with endometrial *** suggest that more research for 17β-HSD needs to explore.

关键词： 17-beta-hydroxysteroid dehydrogenase-type 1 Gene polymorphisms endometrial neoplasms

Accuracy of tumor grade by preoperative curettage and associated clinicopathologic factors in clinical stage Ⅰ endometriod adenocarcinoma

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Chinese Medical Journal 2009年第16期122卷 1843-1846页

作者： WANG Xin-yu PAN Zi-min CHEN Xiao-duan LU Wei-guo XIE Xing Department of Gynecologic Oncology Women's Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310006 China Department of Pathology Women's Hospital School of Medicine Zhejiang University Hangzhou 310006 China

Background Preoperative tumor grading becomes one of the most important predictors for lymphadenectomy at primary surgery for clinical stage Ⅰ endometriod adenocarcinoma. However, there is an inconsistency of tumor grade between preoperative curettage and final hysterectomy specimens, and its associated factors are poorly understood. This study aimed to evaluate the accuracy of tumor grade by preoperative curettage so as to achieve a better stratified management for clinical stage Ⅰ endometriod adenocarcinoma. Methods Clinical data of totally 687 patients with clinical stage Ⅰ endometriod adenocarcinoma who underwent preoperative curettage and primary surgery were retrospectively collected. Compared with final hysterectomy specimens, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of tumor grade by preoperative curettage were calculated and their associations with clinicopathologic parameters, including age, status of menopause, position of uterus, location and size of lesion, histological grade, depth of myometrial invasion, cervical invasion, extrauterine spread, peritoneal cytology, metastasis to retroperitoneal lymph node, serum CA125 level, and hormone receptor status, were analyzed. Results In final hysterectomy specimens, 139 of 259 grade 1 patients by curettage were upgraded to grade 1 or 2; 31 of 296 grade 2 were upgraded to grade 3, with a significantly discrepant rate of 40.9% （281/687） and an upgraded rate of 24.7% （170/687）. The specificity and negative predictive value for grade 3 were 90.7% and 89.9%, while the sensitivity and positive predictive value for grade 1 were 67.1% and 40.9%, respectively. Conclusions Preoperative tumor grade by curettage does not accurately predict final histological results, especially in those classified as grade 1. Complete surgical staging seems to be necessary for clinical stage Ⅰ endometriod adenocarcinoma.

关键词： endometrial neoplasms dilatation and curettage diagnosis tumor grade

Blockage of PI3K/PKB/P27^(kip1) signaling pathway can antagonize 17β-estradiol-induced Ishikawa proliferation and cell cycle progression

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Chinese Medical Journal 2006年第3期119卷 242-245页

作者： GUO Rui-xia WEI Li-hui QIAO Yu-huan WANG Jian-liu TANG Jian-min Department of Gynecology People＇s Hospital Peking UniversityBeijing 100044 China Department of Obstetrics and Gynecology First Teaching HospitalZhengzhou University Zhengzhou 450052 China Department of Internal Medicine People＇s Hospital PekingUniversity Beijing 100044 China

It is well-known that risk for endometrial adenocarcinoma increases in patients with high level ofestrogen that is unopposed by progestin. And activation of extracellular signal-regulated kinase （ERK） and phosphatidylinositol 3 kinase/protein kinase B （PI3K/PKB） pathway are responsible for hormone-dependent cell growth in endometrial carcinoma. PI3K produces phosphatidylinositol- 3-phosphates by phosphory-lating the D3 hydroxyl of phosphoinositides, leading to membrane translocation of PKB,

关键词： endometrial neoplasms estrogens signal transduction pathway cell cycle cell proliferation

OVARIAN METASTASIS IN PATIENT WITH endometrial CARCINOMA

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Chinese Journal of Cancer Research 2005年第3期17卷 230-234页

作者：周凤智陈毅男张国楠 Department of Gynecologic Oncology Sichuan Cancer Hospital

Objective： To study the clinical pathological characteristics of ovarian metastasis of endometrial carcinoma and the factors affecting prognosis. Methods： Retrospective analysis was made to the clinical pathological outcome of endometrial carcinoma patients receiving surgical treatment in our hospital from January 1990 to December 2002. Results： Among the 191 cases of endometrial carcinoma patients, 17 cases （8.9%） had ovarian metastasis and young patients were more likely to have ovarian metastasis. The multiple factor analysis showed that the independent risk factors of ovarian metastasis in endometrial carcinoma included the depth of myometrial invasion, lymph node metastasis and pathological types. Conclusion： Ovarian metastasis in patients with endometrial carcinoma is associated with poor prognosis, the depth of myometrial invasion, lymph node metastasis and histologic types are independent risk factors affecting the prognosis. For young patients at early stage of the disease, it should be prudent as to whether to retain the ovary.

关键词： endometrial neoplasms Ovarian neoplasms Metastasis Prognosis

Synchronous primary cancers of the endometrium and ovary： review of 43 cases

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The Chinese-German Journal of Clinical Oncology 2009年第2期8卷 95-99页

作者： Shaokang Ma Hongtu Zhang Yangchun Sun Lingying Wu Department of Gynecologic Oncology Caner Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100021 China Department of Pathology Caner Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100021 China

Objective： To investigate the clinical and pathological characteristics, treatment methods, and prognosis of synchronous primary cancer of the endometrium and ovary. Methods： The clinical data of 43 patients with synchronous primary cancer of endometrium and ovary were retrospectively reviewed. The survival was calculated by Kaplan-Meier method and compared using the log-rank test. Results： The median age of the patients at diagnosis was 49 years （range, 28-73 years）. The most common symptoms were abnormal vaginal bleeding （69.8%） and abdominal or pelvic pain （44.2%）. Pelvic masses were found in 39.5% of the patients and enlarged corpus in 27.9% at physic examination, while pelvic masses were found in 67.4% of the 43 patients （29 cases） and thickening or abnormal endometrium in 23.3% （10 cases） during ultrasound examination. Of 25 patients examined by CT/MRI, pelvic masses were found in 13 cases and enlarged uterus in 11 cases. All 15 patients who underwent endometrial biopsies were proven to have endometrioid carcinomas. Serum CA125 level was found to be elevated in 22 of the 34 examined cases （64.7%） with median value 500 U/mL （range, 39-3439 U/mL）. FIGO stages of endometrial carcinomas： IA 18 cases, IB 20 cases, IC 2 cases, and ⅡA 3 cases; Stages of ovarian carcinomas： IA 19 case, IB 4 cases, IC 7 cases, Ⅱ 4 cases, and ⅢC 9 cases. Twenty-four patients （55.8%） were in stage I both endometrial and ovarian carcinomas. Thirty-one patients underwent total hysterectomy plus bilateral salpingo-oophorectomy with omentectomy and appendectomy, meanwhile, 12 patients had pelvic lymph nodes dissection. Thirty-eight of the 43 patients （88.4%） had a pathologically proven endometrial adenocarcinomas. The predominant ovarian histologies were endometrioid or mixed tumors with endometrioid components （30/43, 69.8%）. Postoperatively, 26 patients （60.5%） received adjuvant chemotherapy alone, 12 had chemotherapy plus radiotherapy, only one patients had radiation alone and the remaini

关键词： endometrial neoplasms ovary neoplasms synchronous primary cancer therapy prognosis