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Characteristics and clinical role of bronchoscopy in diagnosis of childhood endobronchial tuberculosis

World Journal of Pediatrics 2017年第6期13卷 599-603页

作者： An-Xia Jiao Lin Sun Fang Liu Xiao-Chun Rao Yu-Yan Ma Xi-Cheng Liu Chen Shen Bao-Ping Xu A-Dong Shen Kun-Ling Shen Key Laboratory of Major Diseases in Children Ministry of EducationNational Clinical Research Center for Respiratory DiseasesNational Key Discipline of Pediatrics(Capital Medical University)Department of Interventional PulmonologyBeijing Children's HospitalCapital Medical UniversityNational Center for Children's Health Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Beijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's Health Department of Respiratory Diseases Beijing Children's HospitalCapital Medical UniversityNational Center for Children's Health

Background:endobronchial tuberculosis (EBTB) is the most frequent complication of primary pulmonary tuberculosis (PTB) in *** aim of the study was to analyze characteristics and clinical role of bronchoscopy in diagnosis of childhood ***:A retrospective,descriptive study was undertaken in 157 children with EBTB undergone flexible bronchoscopy (FB) between January 2006 and June ***:The median age of the enrolled patients was 3.4 years,with 73.2% of patients under five years *** most common subtype was tumorous type (145/157,92.4%).If only involved bronchus were considered,the common affected sites were right middle lobe bronchus (49/228,21.5%),left upper lobe bronchus (41/228,18.0%),right upper lobe bronchus (41/228,18.0%),right main bronchus (35/228,15.4%),*** younger than five years old were at higher risk to have multiple endobronchial lesions (P=0.044),with an odds ratio of 2.313 (95% confidence interval:1.009-5.299).Before the bronchoscopy,only 16 (10.2%)patients were highly suspected of EBTB,while the others were diagnosed as PTB without EBTB (69.4%),or misdiagnosed as pneumonia or foreign body aspiration (20.4%) on ***:The patients under five years old are at high risk to progress to EBTB and have multiple endobronchial *** most frequent subtype of EBTB in children is tumorous *** lesions are seen in the right bronchial system more *** should be performed to detect the endobronchial lesions in suspected patients as soon as possible.

关键词： diagnosis endobronchial tuberculosis flexible bronchoscopy

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endobronchial tumor in children:Unusual finding in recurrent pneumonia,report of three cases

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World Journal of Clinical Pediatrics 2015年第2期4卷 30-34页

作者： Silvia Madafferi Vincenzo D Catania Antonella Accinni Renata Boldrini Alessandro Inserra Department of General and Thoracic Surgery Bambino Gesù Children Hospital-Resarch Institute Department of Pathology Bambino Gesù Children Hospital-Resarch Institute

We are reporting 3 cases of pediatric endobronchialtumors presented with recurrent pneumonia. The median age of patients, at time of presentation, was 10.6 years. All patients presented with recurrent pneumonia with a mean time to occurrence, after onset of symptoms, of 14 mo. Bronchoscopy was early performed as part of diagnostic work-up and it revealed an endobronchial mass in every case. Complete surgical resection was performed in all cases, with lung preservation in two of them. Neither post-operative chemotherapy nor radiotherapy was required. The mean duration of follow-up was 7 years and all patients are still alive and disease-free. Recurrent pneumonia, in pediatrics, should raise the suspicion of an obstructing lesion, congenital malformation or systemic disease. A systematic approach is useful for organize the clinicians initial workup. Prompt diagnosis allows parenchymal-sparing surgery, which offers the best chance of cure and reduces clinical and functional complications in these patients.

关键词： Recurrent pneumonia Pediatric endobronchial tumor Mucoepidermoid tumor Carcinoid tumor

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endobronchial metastasis from adenocarcinoma of gastric cardia 7 years after potentially curable resection

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World Journal of Gastrointestinal Surgery 2010年第8期2卷 270-274页

作者： Takaaki Hanyu Tatsuo Kanda Atsushi Matsuki Go Hasegawa Kazuhito Yajima Masanori Tsuchida Shin-ichi Kosugi Makoto Naito Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Division of Cellular and Molecular Pathology Niigata University Graduate School of Medical and Dental Sciences Division of Thoracic and Cardiovascular Surgery Niigata University Graduate School of Medical and Dental Sciences

endobronchial metastasis(EBM) is a rare form of metas-tasis from extrapulmonary malignant tumors,although there are few reports of EBM from gastric cancer *** report the case of a 51-year-old woman who had undergone gastrectomy for advanced gastric cancer seven years previously but was diagnosed with a solitary lung tumor by follow-up computed *** diagnosis of primary lung cancer,she underwent pulmonary lobectomy,but immunohistochemical examination confirmed the resected tumor to be an EBM from the gastric *** months later,she was diagnosed with peritoneal metastases and underwent chemotherapy with gastric cancer *** is still alive at 33 mo after the ***,the prognosis for EBM is poor although multidisciplinary treatment can lead to long-term *** diagnosis on the basis of detailed pathological and immunohistochemical evaluation can contribute to deciding the most effective treatment and improving prognosis.

关键词： endobronchial metastasis Immunohisto-chemistry Gastric cancer

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A case with lethal endobronchial lymphoma presenting with respiratory failure requiring intubation and mechanical ventilation

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Chinese Medical Journal 2008年第3期121卷 280-282页

作者： ZHANG Gen-sheng XU Zhi-hao CUI Wei ZHOU Fang XIA Yi LI Wen LI Li-bin SHEN Hua-hao Intensive Care Unit Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Departmnent of Respiratory Medicine Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Pathology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China

Non-Hodgkin＇s lymphoma （NHL） affects thoracic structures, particularly mediastinum and lung parenchyma, in up to 43% of patients at some stage in the course of the disease,1 endobronchial involvement, however, is extremely rare, even in the presence of advanced disease. Since the first report of endobronchial NHL in 1955,2 there were few reports on the cases with this disease identified by bronchoscopic examination in the English literature.3-14To our knowledge, the patient described in this report is an extremely rare case presenting with respiratory failure as the initial manifestation requiring intubation and mechanical ventilation soon after admission.

关键词： non-Hodgkin's lymphoma endobronchial respiration failure

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Invasive Thymoma with endobronchial Polypoid Growth

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Open Journal of Respiratory Diseases 2015年第4期5卷 71-74页

作者： Samira Aouadi Emna Braham Ayda Ayadi Houda Gharsalli Asma Zidi Adel Marghli Sonia Maalej Leila Douik El Gharbi Respiratory Department D Aberrahmene Mami Hospital University of Medicine Tunis Tunis Tunisia Laboratory of Pathology Aberrahmene Mami Hospital University of Medicine Tunis Tunis Tunisia Department of Radiology Aberrahmene Mami Hospital University of Medicine Tunis Tunis Tunisia Department of Thoracic Surgery Aberrahmene Mami Hospital University of Medicine Tunis Tunis Tunisia

Thymomas are the most common neoplasms of the mediastinum. It is common that thymoma invades neighboring structures in the thorax, but direct polypoid tumor growth into the airway is extremely rare. We report a rare case of invasive thymoma with polypoid endobronchial growth in a 66-year-old woman. Computed tomography demonstrated an anterior mediastinal tumor which extended into the right upper lobe. Endoscopic examination revealed a polypoid tumor which occluded the right upper bronchus. A biopsy specimen obtained from the intraluminal mass was very suggestive of thymoma. The patient had no parathymic syndrome. The tumor was resected with the right upper lobe. The final post-operative tissue findings confirmed a type B2 thymoma of the World Health Organisation classification.

关键词： Invasive Thymoma Anterior Mediastinal Tumor Bronchoscopy endobronchial Growth

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Training benefits of virtual bronchoscopy prior to endobronchial Ultrasound Guide sheath

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Open Journal of Clinical Diagnostics 2011年第3期1卷 9-14页

作者： D. Fielding F. Bashirzadeh P. Nguyen 不详

Research questions. How does a virtual bronchoscopy navigation system (VBNS) improve prediction of candidate bronchus across a range of doctors investigating a range of lesions with endobronchial ultrasound (EBUS) guide sheath? To what extent do benefits of virtual bronchoscopic pre-procedure navigation apply to experienced versus inexperienced bron- choscopists? Methods: Using archived EBUS Guide sheath cases, a comparison was made between identified candidate 4th order bronchus by Computerised tomography (CT) evaluation versus that identified after virtual path creation. Results: From 7 archived cases, 14 doctors identified the correct bronchus in 94 of 98 assessments (95%). Percentage of cases where there was an improvement in localisation by 2 or more 4th order bronchi was 39.8% overall (28.6% – 51.0%), 26.6 for experienced and 53.1 for inexperienced bronchoscopists (p < 0.02). The absolute mean number of 4th order bronchi different between CT and VBNS was 2.0 ± 2.6 overall, 1.2 (range 0-6) for experienced, and 2.8 (range 0-11) for inexperienced bronchoscopists. Virtual Path software calculation time was 8.1 ± 2.7 minutes, compared to 3.6 ± 2.1 minutes by CT. Conclusion: VBNS allowed rapid accurate assessment with minimal software training. Greatest benefits in reduction of procedure time were obtained in inexperienced bronchoscopists, and VBNS could allow more rapid skill development in EBUS GS in these doctors.

关键词： Virtual Bronchoscopy Lung Neoplasms and Solitary Pulmonary Nodule/Diagnosis Transbronchial Biopsy Three-Dimensional Imaging endobronchial Ultrasonography

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A Case of COPD with Left endobronchial Hamartoma by Bronchoscopic Intervention

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Case Reports in Clinical Medicine 2018年第11期7卷 550-556页

作者： Yi Gong Lu Lu Feng Long Haihua Yang Xiaodong Chen Shengqing Li Department of Respiratory Medicine Huashan Hospital North Fudan University Shanghai China Department of Respiratory Disease Huashan Hospital Fudan University Shanghai China Department of Pathology Huashan Hospital North Fudan University Shanghai China

Objective: Exploration for chronic obstructive pulmonary disease with branched air lumen hamartoma by bronchoscoptic treatment. Material and Method: An old man was referred to our hospital with shortness of breath for many years. Clinical evidence emphysema on respiratory examination, lung function and chest X-ray gave rise to concern. He was diagnosed as COPD and treated with ICS + LABA. But the shortness of breath is still existed. Initial assessment by CT suggested a left lower lobe collapse. Then bronchoscope identified a solid abnormality in main left bronchus. The pathology showed a benign neoplasm. Because of intolerance of operation, the patient was treated by brochoscopic intervention. The endoscopic intervention included resection by electrosurgical snare, electrocautery, argon plasma coagulation (APC). Result: After intervention, the neoplasm was partly removed and the pathological result was endobrochial hematoma. After treatment, the patient’s panting had taken a turn for the better. After one month later, the patient’s lung function improved a lot. Conclusion: In conclusion, endobronchial hamartomas are one of benign neoplasms. It can cause persistent bronchial obstruction and recurrent pneumonias. In this case, invasive endoscopic treatment provides an excellent outcome.

关键词： endobronchial Hamartoma (EH) Bronchoscopic Intervention COPD

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Virtues of Using a Double Lumen Tube for Anesthesia in Patients with endobronchial Tumours Requiring Open Lung Resection or Bronchoplastic Procedures

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Open Journal of Anesthesiology 2020年第1期10卷 1-12页

作者： Assem Adel Moharram Hany Hasan Elsayed Faculty of Medicine Ain Shams University Cairo Egypt

Objective The benefits and risks of using double lumen tube (DLT) in open thoracotomy are not well studied and the relative contraindication for using it in cases of endobronchial tumours is not proven. In this study, we compared our experience with using DLT versus single lumen tube (SLT) for anesthesia in patients requiring an open thoracotomy for resection of endobronchial tumours. Methods A prospective observational study was performed in a single tertiary care university hospital in patients with endobronchial tumours anesthetized with single and double lumen tubes for open thoracotomy procedures over a period from 2010 till 2018. Results One hundred and six patients with endobronchial tumours were studied. There were 76 males. Median age was 32 years (14 - 62). In 96 cases, endobronchial pathology was a typical carcinoid. 58 patients were anesthetized using a DLT and 48 using a SLT. Four cases of near miss from potentially fatal intraoperative tumour migration occurred in the SLT group (p = 0.025). There was only one case of mild tumour bleeding from the DLT group and time of insertion was longer (16.2 vs. 4.5 min p Conclusions We conclude that it is safe to place a double lumen endo tracheal tube for patients with endobronchial tumours requiring open lobectomies or bronchoplastic procedures. An additional benefit of DLT use is increasing surgical satisfaction by reducing spillage and tidal volume loss during surgical anastomosis of the open airway.

关键词： Double Lumen Tube endobronchial Tumor Thoracotomy

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Historical transition of management of sarcoidosis

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World Journal of Respirology 2015年第1期5卷 4-16页

作者： Minoru Inomata Satoshi Konno Arata Azuma Department of Pulmonary Medicine and Oncology Graduate School of MedicineNippon Medical School First Department of Medicine Hokkaido University School of Medicine

Sarcoidosis is a systemic granulomatous disease of undetermined etiology, and it primarily affects the lungs and lymphatic system but may involve other organs. Recently, there have been several new insights in Japanese patients. The frequency of cardiac, ocular, and cutaneous sarcoidosis has increased in Japan, whereas, the proportion of patients with bilateral hilar lymphadenopathy decreased from 1960 to *** acnes(P. acnes) has been studied extensively as one of the causative microorganism for granuloma formation, particularly in Japan. P. acnes-specific monoclonal antibodies are useful for diagnosing sarcoidosis. The potential association between smoking and sarcoidosis has been evaluated in a Japanese study, which found a higher prevalence of sarcoidosis among young smokers than that in previous reports. Recently, 18F-fluorodeoxyglucose positron-emission tomography, which permits visualization of activated inflammation, and endobronchial ultrasonography-guided transbronchial needle aspiration have been increasingly used to diagnose sarcoidosis. Cardiac sarcoidosis is found to be the main cause of death in Japan. The 2006 revised Japanese guidelines for diagnosing cardiac sarcoidosis are useful, particularly for subclinical cardiac sarcoidosis patients. Further studies and international communication and evaluation are needed to determine the causes of sarcoidosis, identify the risk factors for progressive disease, and develop new and effective treatments.

关键词： Japan Propionibacterium acnes Smoking Cardiac sarcoidosis Positron-emission tomography endobronchial ultrasonography-guided transbronchial needle aspiration

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