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Epstein-Barr virus-encoded RNAs as a survival predictor in nasopharyngeal carcinoma

Chinese Medical Journal 2014年第2期127卷 294-299页

作者： Ke Kengjian Wang Haiyun Fu Sha Zhang Zichen Duan Liping Liu Dabo Ye Jin Department of Otolaryngology Guangzhou Women and Children's Medical Center Guangzhou Children's Hospital Guangzhou Guangdong 510120 China State Key Laboratory of Oncology in South China Department of Molecular Diagnostics Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 China Institute of Scientific and Technical Information of China (ISTIC) Beijing 100038 China Department of Otolaryngology the Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510623 China

Background Epstein-Barr virus （EBV） infection is one of the most important factors of nasopharyngeal carcinoma （NPC）endemic *** of EBV-encoded non-polyadenylated RNAs （EBERs） are presented in most of NPC *** EBERs as a prognostic marker for NPC might further be informative about the biology and the progression of the *** aim of this study was to analyze the role of EBV latency in the clinical management of nasopharyngeal carcinoma （NPC）,by detecting *** RNA in situ hybridization （ISH） for detecting EBERs was carried out on 908 NPC tumor *** survival （OS） curves were analyzed with the Kaplan-Meier method and the Cox proportional-hazards regression *** The median follow-up time was 70 months （1-120 months）.Eight hundred and sixteen （89.9％） from a total of 908 consecutive NPC cases were found to be EBV-EBER ***-ISH staining revealed nuclear localization in NPC *** the Kaplan-Meier analysis for OS,high EBER expression levels in NPC patients were statistically significant positive prognostic factors for survival （log-rank,P=0.022）,especially in adults aged 17-40 years （P=0.023） and in those with advanced stage disease （log-rank,P=0.002）.Cox proportional-hazards regression model analysis showed that the EBER expression level was an independent risk factor for OS （hazard ratio 0.724,P=0.005）.Conclusions EBERs were frequently detected in NPC tumor tissues,and high-level EBER expression correlated with good prognosis in NPC patients,especially in adult patients and in those with advanced stage *** may serve as a potential prognostic predictor in NPC.

关键词： Epstein-Barr virus-encoded RNAs nasopharyngeal carcinoma endemic areas prognosis

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