检索结果-南通市图书馆

White matter connection's damage,not cortical activation, leading to language dysfunction of mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes

引用

Chinese Medical Journal 2019年第5期132卷 597-599页

作者： Na Ye Jing-Yi Liu Xi-Ping Gong HuiQu Ke-Hui Dong Yan-Ling Ma Wei-Li Jia Zhao-Zhao Wang Yuan-Jun Li Yu-Mei Zhang Department of Neurology Beijing Tiantan Hospital Capital Medical University China National Clinical Research Center for Neurological DiseasesCenter of Stroke Beijing Institute for Brain DisordersBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Beijing Key Laboratory of Central Nervous System Injury Beijing 100070 China Department of Neuroradiology Beijing Tiantan Hospital Capital Medical University Beijing 100070 China Department of Rehabilitation Medicine Beijing Tiantan Hospital Capital Medical UniversityBeijing 100070 China

Mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS) is a metabolic disorder characterized by hyperlactic acidemia and stroke-like symptoms.

关键词： language dysfunction mitochondrial encephalomyopathy lactic acidosis strokelike episodes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mortality in mitochondrial encephalomyopathy,lactic acidosis,and stroke-like episodes does not depend on levetirazetam alone

引用

Chinese Medical Journal 2019年第12期132卷 1512-1512页

作者： Josef Finsterer Krankenanstalt Rudolfstiftung Messerli InstituteVeterinary University of ViennaViennaAustria

We appreciated reading the article by Zhang et al[1] about a retrospective study of 102 mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) patients with epilepsy in which disability and outcome were assessed (median follow-up: 4 years). Administration of levetirazetam (LEV) was associated with a better outcome compared to other antiepileptic drugs (AEDs).[1] The study has several shortcomings requiring discussion.

关键词： Mortality in mitochondrial encephalomyopathy levetirazetam alone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Late-onset mitochondrial disease in a patient with MELAS and mitochondrial DNA T14487C mutation

引用

Chinese Medical Journal 2019年第6期132卷 716-718页

作者： Xue-Bi Xu Kun-Qian Ji Jing-Wei Lyu Shu Zhang Xiao-Qing Lyu Chang Liu Wei Li Chuan-Zhu Yan Yu-Ying Zhao Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology Qilu Hospital Shandong University Jinan Shandong 250000 China Brain Science Research Institute Shandong University Jinan Shandong 250000 China Mitochondrial Medicine Laboratory Qilu Hospital Shandong University Qingdao Shandong 266035 China

To the Editor: Mitochondrial encephalomyopathy with lactate acidosis and stroke-like episodes (MELAS) is one of the most common multisystem mitochondrial disorders with broad clinical manifestations.[1] It is usually caused by point mutations in the mitochondrial MT-TL1 gene, which accounts for approximately 80% of mutations in individuals with MELAS syndrome.[2] Pathogenic mitochondrial DNA (mtDNA) mutations were first described in 1980[3] and m.l4487T>C is a known pathogenic mtDNA mutation,[4] which has been reported in patients with Leigh syndrome, optic neuropathy, ptosis, dystonia, and encephalomyopathy. We herein report a patient with late-onset MELAS syndrome with the m.l4487T>C mutation for the first time.

关键词： Editor Mitochondrial encephalomyopathy lactate acidosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：