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Chinese Journal of Chemistry 2002年第7期20卷 663-669页

作者：刘月启韩小茜齐邦峰柳春辉李永民陈立仁 Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China

Cellulose tris(4-methylphenylcarbamate), amylosetris(3,5-di-methylphenylcarbamate) and amylose tris (phenylcarbamate) were prepared by the methodreported by Okamoto and were coated onto an aminopropylated mesoporous spherical silica gel. Thesefinal products were used as chiral stationary phases of high performance liquid chromatography forthe eighteen structurally related biphenyl compounds. The resolution was made using normal-phasemethodology with a mobile phase consisting of n-hexane-alcohol (ethanol, 1-propanol, 2-pro-panol or1-butanol). The effects of various aliphatic alcohols in the mobile phase were studied. Thestructural features of the solutes that influence then- k′ were discussed. A dominant effect oftrifluoroacetic acid on chiral separation of acidic solutes was noted.

关键词： enantiomer separation HPLC chiral stationary phase α-dimethyldicarboxylate biphenyl and related biphenyl compounds

Direct enantiomer separation of 2-PhenylcyclopropanecarboxylateEsters on Cyclodextrin Derivatives Stationary Phases in GC

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Chinese Chemical Letters 1999年第11期10卷 933-936页

作者： Meng Yan NIE Liang Mo ZHOU Xue Liang LIU Qing Hai WANG Dao Qian ZHU(Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116012) Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116012 China

Direct enantiomeric separation of all four optical isomers of 2-phenylcyclopropane carboxylate ester was first achieved on each of the three different beta-cyciodextrin chiral stationary phases (CSPs) in GC. Using these CSPs, enantiomeric excess of the products of enantioselective cyclopropanation can be determined directly, conveniently and fast.

关键词： enantiomer separation 2-phenylcyclopropanecarboxylates cyclodextrin

The enantiomer separations of Allethrone and Propargyllone Using Two Long Chain Acylated b-Cyclodextrin Derivatives as CGC Capillary Stationary Phases

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Chinese Chemical Letters 2002年第10期13卷 973-976页

作者： Xue Yan SHI Hong Chao GUO Zhen QIAO Shi Cong HOU Min WANG Key Laboratory of Pesticide Chemistry and Application Technology College of Applied ChemistryChina Agricultural UniversityBeijing 100094

Using two b-cyclodextrin derivatives (CDs) with long chain of acyl groups as chiral stationary phases (CSPs) of capillary gas chromatography (CGC), the enantiomers of racemic allethrone and propargyllone were well resolved after derived with acetyl chloride. The enantiomer excess values (e.e.%) of 1S-allethrone and 1S-propargyllone were also determined successfully using these CDs.

关键词： enantiomer separation allethrone propargyllone capillary gas chromatography (CGC) b-cyclodextrin derivatives.

New cocktail functional monomers in making molecule imprinting polymer with high chiral selectivity

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Progress in Natural Science:Materials International 1999年第10期9卷 73-76页

作者：孟子晖王进防周良模王清海朱道乾 China Chinese Academy of Sciences Dalian 116012 Dalian Institute of Chemical Physics

In order to produce molecule imprinting polymer (MIP) with high chiral selectivity against Na-pro-tected amino acid, new cocktail functional monomers acrylamide (AM) + 2-vinylpyridine (2-VP) and AM + methacrylic acid (MAA) were investigated. AM + 2-VP was found to be more efficient in improving the selectivity and resolution of the molecule imprinting polymer.

关键词： molecule imprinting enantiomer separation chiral stationary phase amino acid

enantiomeric separation of Epinephrine and Salbutamol by Micellar Electrokinetic Chromatography Using β-Cyclodextrin as Chiral Additive

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Chinese Chemical Letters 2004年第10期15卷 1209-1211页

作者： YanPengZHENG JinYuanMO SchoolofScience BeijingJiaotongUniversityBeijing100044 SchoolofChemistryandChemicalEngineering ZhongshanUniversityGuangzhou510275

enantiomeric separation of epinephrine and salbutamol was investigated by micellar electrokinetic chromatography employing β-cyclodextrin as chiral additive in ammonium chloride-ammonia solution. The analytes were detected by electrochemistry using gold microelectrode at +0.65 V versus SCE reference electrode. The effects of detection potential, concentration of β-cyclodextrin, concentration of sodium dodecyl sulfate, pH value of electrolyte and applied voltage were discussed.

关键词： Micellar electrokinetic chromatography electrochemical detection enantiomer separation epinephrine salbutamol.

enantiomeric separation of phenylsuccinic acid by cyclodextrin-modified reversed phase high-performance liquid chromatography

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Journal of Central South University 2009年第2期16卷 201-205页

作者：满瑞林王钟辉唐课文 School of Chemistry and Chemical Engineering Central South University Department of Chemistry and Chemical Engineering Hunan Institute of Science and Technology

The chiral separation of phenylsuccinic acid(PSA)was studied by reversed phase high-performance liquid chromatography(RP-HPLC)with cyclodextrins(CDs)as chiral mobile phase *** effects of types of CDs,concentration of hydroxypropyl-β-cyclodextrin(HP-β-CD),percentage of organic modifier,pH value and column temperature on enantioselective separation were *** quantification property of the developed RP-HPLC method was *** chiral recognition mechanism of PSA was also *** results show that a baseline separation of PSA enantiomers is achieved on a Lichrospher C18 column(4.6 mm(inner diameter)×250 mm,5μm)with HP-β-CD as chiral mobile phase *** capacity factors of R-PSA and S-PSA are 3.94 and 4.80,*** separation factor and resolution are respectively 1.22 and *** mobile phase is a mixture of acetonitrile and deionized water(20-80,volume ratio)containing 10 mmol/L HP-β-CD and 0.05% trifluoroacetic acid(pH 2.5,adjusted with triethylamine)with a flow rate of 1.0 mL/*** ultraviolet(UV)detector is set at 254 *** likely roles are inclusion interaction,induction and hydrogen bonding between HP-β-CD and PSA enantiomers.

关键词： high performance liquid chromatography hydroxypropyl-β-cyclodextrin enantiomer separation phenylsuccinic acid

enantiomeric separation of Epinephrine and Salbutamol by Micellar Electrokinetic Chromatography Using β-Cyclodextrin as Chiral Additive

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Chinese Journal of Chemistry 2004年第8期22卷 845-848页

作者：郑妍鹏莫金垣 School of Science Beijing Jiaotong University Beijing 100044 China School of Chemistry and Chemical Engineering Zhongshan University Guangzhou Guangdong 510275 China

enantiomeric separations of epinephrine and salbutamol, by means of micellar electrokinetic chromatography (MEKC) employing β-cyclodextrin as chiral additive in ammonium chloride-ammonia solution were investigated. In this system, the analytes migrated with the micellar phase towards the anode and were detected by electrochem- istry using gold microelectrode at +0.65 V vs. SCE. The success of the chiral separations is strongly dependent on the concentration of β-CD and SDS, and the optimal concentration is 8 mmol?L-1 and 15 mmol?L-1 respectively. The effects of detection potential, pH value of electrolyte and applied voltage were discussed also. Using the pro- posed method, baseline separation of the enantiomers could be accomplished in 6 min. Further, an attempt was made to elucidate the plausible mechanism of the chiral recognition.

关键词： micellar electrokinetic chromatography electrochemical detection enantiomer separation epineph- rine salbutamol

Chiral separation of Chlorpheniramine by Capillary Electrophoresis *L

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Journal of Beijing Institute of Technology 1999年第1期8卷 61-65页

作者：卢光菊顾峻岭张健傅若农北京理工大学化工与材料学院

Aim To study the chiral separation of chlorpheniramine(Chp) by using a mixture of β CD and glutamate β CD as the chiral additive in CE. Methods Mixture of β cyclodextrin and glutamate β cyclodextrin was used as a chiral selector to the separation of chlorpheniramine. The effects of the concentrations of β cyclodextrin and glutamate β cyclodextrin, the voltage and the pH of buffers on the separation of chlorpheniramine were studied. Results The chiral recognization of the mixed chiral selector was better than that of a single selector. At pH below 4, the pH of buffers did not affect the separation and the separation of chlorpheniramine had good reproducibility. Conclusion Using a mixture of β CD and Glu β CD as chiral selector is useful for the enantioseparation of Chp in CE.

关键词： capillary electrophoresis enantiomer separation cyclodextrin additives chlorpheniramine

Enantioselective Determination of R-(-)-and S-(+)-Mexiletine in Microsomal Incubates by Capillary gas Chromatography

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Journal of Chinese Pharmaceutical Sciences 1998年第4期7卷 34-37页

作者：王似菊毛海琼曾苏浙江医科大学药学院

A method for the assay of R ( ) and S (+) mexiletine in rat liver microsomal incubates was developed. The method involved extraction of mexiletine from the microsomal incubates, and formation of mexiletine diastereomeric derivatives with a chiral reagent S ( ) N trifluoroacetyl prolyl chloride. separation and quantitation of the diastereomeric mexiletine derivatives were carried out by a capillary gas chromatographic system with flame ionization detection. The assay was linear from 5 to 500 μg/ml for each enantiomer. The average recoveries of analytical method were 93 31±5 59% and 93 10±5 11% for R ( ) and S (+) mexiletine, respectively. The limits of detection and quantitation for the method were 1 0 μg/ml and 5 0 μg/ml for the R ( ) and S (+) mexiletine isomers, respectively. The reproducibility in the assay was better than 16.5% (RSD). The method has been applied to the metabolism study of R ( ) and S (+) mexiletine in rat liver microsomal incubates.

关键词： Mexiletine Capillary gas chromatography enantiomer separation

Liquid Chromatographic Resolution of Racemic ?-Amino Acids,Amines and Amino Alcohols on Two New Improved Chiral Crown Ether Stationary Phases

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Liquid Chromatographic Resolution of Racemic ?-Amino Acids,A...