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Assessment of embryotoxicity of compounds in cosmetics by the embryonic stem cell test

Assessment of embryotoxicity of compounds in cosmetics by th...

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第八届中国化妆品学术研讨会

作者： Bruce T.Lahn Andy Peng Xiang Center for stem cell Biology and Tissue Engineering Sun Yat-sen University

The new EU legislations for cosmetics(Seventh Amendment) have laid down deadlines for the replacement of animal tests in cosmetics.This policy stimulates the acceptance of in vitro approaches to test embryotoxic potentials of compounds in cosmetics products.The embryonic stem cell test(EST) designed by The European Centre for the Validation of Alternative Methods(ECVAM) is currently the most promising in vitro assay to predict the embryotoxic potential of compounds.In this study,six selected compounds (hydroquinone,eugenol,dibutyl phthalate,antimony(Ⅲ) oxide,neodymium(Ⅲ) nitrate hydrate,melamine) formerly involved in cosmetic products were selected to test their embryotoxic potentials by the EST. 5-Fluorouracil and penicillin G were separately set as positive and negative control.The embryotoxic potential was determined by the prediction model(PM),which was calculated from three endpoints,the IC50 3T3,IC50 ES,and ID50.Hydroquinone,eugenol,and antimony(Ⅲ) oxide indicated with strong embryotoxicity,while dibutyl phthalate,neodymium(Ⅲ) nitrate hydrate,and melamine exhibited a weak embryotoxicity.These results may provide a valuable attempt to expand the application of EST to the cosmetics field.

关键词： Cosmetics embryotoxicity embryonic stem cell test

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Assessment of embryotoxicity of compounds in cosmetics by the embryonic stem cell test

Assessment of embryotoxicity of compounds in cosmetics by th...

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第九届中国实验动物科学年会（2010新疆）

作者： Rui Chen1,2,Jing Chen1,2,Shujun Cheng3,Jie Qinl,2,Weiqiang Lil,2,Lirong Zhang4,Hong Jiao3, Xinbing Yu1,2,Xiuming Zhang1,2,Bruce T.Lahn1,2,and Andy Peng Xiang1,2 1 Center for stem cell Biology and Tissue Engineering,Sun Yat-sen University,74# Zhongshan Road 2, Guangzhou, Guangdong.PR China 510080,2The Key Laboratory for stem cells and Tissue Engineering,Ministry of Education, Guangzhou 510080,PR China,3 Food Lab of Guangdong Entry-Exit Inspection and Quarantine Technology Center. Guangzhou 510623,PR China,and 4Department of Pathophysiology,Guangdong College of Pharmacy, Guangzhou 510006,PR China

Objective The new EU legislations for cosmetics(Seventh Amendment) have laid down deadlines for the replacement of animal tests in cosmetics.This policy stimulates the acceptance of in vitro approaches to test embryotoxic potentials of compounds in cosmetics products.The embryonic stem cell test(EST) designed by The European Centre for the Validation of Alternative Methods(ECVAM) is currently the most promising in vitro assay to predict the embryotoxic potential of compounds.In this study,six selected compounds(hydroquinone,eugenol,dibutyl phthalate,antimony(Ⅲ) oxide,neodymium(Ⅲ) nitrate hydrate,melamine) formerly involved in cosmetic products were selected to test their embryotoxic potentials by the EST.5-Fluorouracil and penicillin G were separately set as positive and negative control.The embryotoxic potential was determined by the prediction model(PM),which was calculated from three endpoints,the IC50 3T3,IC50 ES,and ID50.Hydroquinone,eugenol,and antimony(Ⅲ) oxide indicated with strong embryotoxicity,while dibutyl phthalate,neodymium(Ⅲ) nitrate hydrate,and melamine exhibited a weak embryotoxicity.These results may provide a valuable attempt to expand the application of EST to the cosmetics field.

关键词： Cosmetics embryotoxicity embryonic stem cell test

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