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Local Shear Stresses elicit Different Mechanical Response and Gene Expression from Complex Stresses

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医用生物力学 2019年第A1期34卷 147-147页

作者： Fuxiang Wei Cunyu Zhang Yawen Liao Ning Wang Laboratory for Cellular Biomechanics and Regenerative Medicine Department of Biomedical EngineeringCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan430074China Department ofMechanical Science and Engineering College of EngineeringUniversity of Illinois at Urbana-ChampaignUrbanaIL61801USA

It is well established that living cells and tissues respond to mechanical forces such as flow-related shear stresses in blood or interstitial space and complex tractional stresses at cell-matrix contacts and cell-cell ***,how different modes of forces impact mechanical and biological responses is *** we describe a strategy of using the three-dimensional magnetic twisting cytometry(3D MTC)technology to apply forces in any desired directions to the same living *** reveal that for a fixed stress amplitude and frequency,a live cell exhibits mechanical anisotropy and responds to a local shear stress differently from responding to a local complex stress by stretching chromatin and upregulating gene transcription to different levels,extending our previous finding on force-induced direct gene *** finding highlights the importance of force modes in impacting cellular mechanical and biological responses in living cells and tissues and may have implications in tissue patterning and embryonic development.

关键词： Local Shear Stresses elicit Different Mechanical Response Gene Expression Complex Stresses

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THE STUDIES OF MALIGNANT TRANSFORMATION OF HUMAN EPITHELIAL CELLS INDUCED BY DIETHYL-NITROSAMINE (NDEA) IN VITRO

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中国科学B辑(英文版) 1986年第11期29卷 1186-1191页

作者：黄明王秀琴王志华周传农吴旻 Cancer Institute Chinese Academy of Medical Sciences Beijing Beijing

This is the first report on the diethylnitrosamine-induced malignant transformaton of hu-man epithelial cells derived from fetal kidney. The transformed cells have prolonged life span and aneuploid karyotypes. They also form anchorage independent colonies in soft agar. With additional one or two NDEA treatments, those cells could elicit poorly differontiated carcinomas in immunosuppressed new-born rats. This experiment indicates that the human fetal kidney cells seem to be a good material for studying the mechanisms of carcinogenesis of human epithelial cell.

关键词： carcinogenesis fetal anchorage carcinomas poorly prolonged IN VITRO NDEA transformed elicit

PURIFICATION OF PEANUT AGGLUTININ BY AFFINITY CHROMATOGRAPHY ON LACTOSE-STARCH GEL

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Chinese Science Bulletin 1984年第6期29卷 823-827页

作者：孙册丁昌荣沈昭文 Shanghai Institute of Biochemistry Academia Sinica

Peanut agglutinin (PNA) is also known by the name 'anti-T-agglutinin' on account of its ability to elicit an immune reaction similar to that brought about by anti-Tantibody in serum. It has thus replaced anti-T-antibody in clinical tests for polyagglutination capacity of T cells. Also PNA is of value in differentiating and separating mature from immature thymocytes, only the immature cells being agglutinated.

关键词： agglutinin immature elicit distilled replaced Reagent butadiene affinity separating Shandong

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Effective cellular vaccines generated by in vitro or in vivo modification of tumor cells using gene transfer approaches for cancer immunogene therapy

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中国实验血液学杂志 1997年第3期5卷 284-285页

作者： Y.J.Guo F.Shen T.P.Xie X.Che Z.F.Cui L.Shi J.Ma S.G.Wu X.N.Wang G.L.Liu Y.Liu H.Wang H.L.Huang L.X.Wei J.Zhao J.Trojan A.Ly D.Anthony M.C.Wu Tumor Immunology and Gene Therapy Center Institute of Hepatobiliary Surgery and Changhai HospitalThe Second Military Medical University and Sidney Kimmel Cancer CenterCaliforniaUSA

Tumor cells escape host immune surveillance bydown-regulation of MHC and/or ***-tumor immune responses are mediated primarily by T cells.A deficiency in either MHC or co-stimulatory molecules on tumor cells is associa... 详细信息

关键词： vaccines surveillance immunity transfection recurrence manner escape curative elicit inducing

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