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eleutheroside b or e enhances learning and memory in experimentally aged rats

Neural Regeneration Research 2013年第12期8卷 1103-1112页

作者： Debin Huang Zehua Hu Zhaofen Yu Department of Pharmacology Hubei Institute for Nationalities

eleutheroside b or e, the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition. Numerous studies have confirmed that high doses of acetylcholine significantly attenuate clinical symptoms and delay the progression of Alzheimer＇s disease. The present study replicated a rat model of aging induced by injecting quinolinic acid into the hippocampal CA1 region. These rats were intraperitoneally injected with low, medium and high doses of eleutheroside b or e （50, 100, 200 mg/kg）, and rats injected with Huperzine A or PbS were used as controls. At 4 weeks after administration, behavioral tests showed that the escape latencies and errors in searching for the platform in a Morris water maze were dose-dependently reduced in rats treated with medium and high-dose eleutheroside b or e. Hematoxylin-eosin staining showed that the number of surviving hippocampal neurons was greater and pathological injury was milder in three eleutheroside b or e groups compared with model group. Hippocampal homogenates showed enhanced cholinesterase activity, and dose-dependent increases in acetylcholine content and decreases in choline content following eleutheroside b or e treatment, similar to those seen in the Huperzine A group. These findings indicate that eleutheroside b or e improves learning and memory in aged rats. These effects of eleutheroside b or e may be mediated by activation of cholinesterase or enhanced reuse of choline to accelerate the synthesis of acetylcholine in hippocampal neurons.

关键词： neural regeneration traditional Chinese medicine eleutheroside b or e quinolinic acid aged rats Huperzine A learning and memory hippocampus acetylcholine cholinesterase choline mechanism grants-supported paper neuroregeneration

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