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Comparison of the analgesic effects between electro-acupuncture and moxibustion with visceral hypersensitivity rats in irritable bowel syndrome

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World Journal of Gastroenterology 2017年第16期23卷 2928-2939页

作者： Ji-Meng Zhao Liang Li Liu Chen Yin Shi Yu-Wei Li Hai-Xia Shang Lu-Yi Wu Zhi-Jun Weng Chun-Hui Bao Huan-Gan Wu Shanghai Institute of acupuncture-Moxibustion and Meridian Shanghai 200030China Institute of acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Shanghai University of Traditional Chinese Medicine Shanghai 201203China

AIM To observe whether there are differences in the effects of electro-acupuncture(EA) and moxibustion(Mox) in rats with visceral hypersensitivity. METHODS EA at 1 m A and 3 m A and Mox at 43?℃ and 46?℃ were applied to the Shangjuxu(ST37, bilateral) acupoints in model rats with visceral hypersensitivity. Responses of wide dynamic range neurons in dorsal horns of the spinal cord were observed through the extracellular recordings. Mast cells(MC) activity in the colons of rats were assessed, and 5-hydroxytryptamine(5-HT), 5-hydroxytryptamine 3 receptor(5-HT3R) and 5-HT4Rexpressions in the colons were *** Compared with normal control group, responses of wide dynamic range neurons in the dorsal horn of the spinal cord were increased in the EA at 1 m A and 3 m A groups(1 m A: 0.84 ± 0.74 vs 2.73 ± 0.65, P < 0.001; 3 m A: 1.91 ± 1.48 vs 6.44 ± 1.26, P < 0.001) and Mox at 43?℃ and 46?℃ groups(43?℃: 1.76 ± 0.81 vs 4.14 ± 1.83, P = 0.001; 46?℃: 5.19 ± 2.03 vs 7.91 ± 2.27, P = 0.01). MC degranulation rates and the expression of 5-HT, 5-HT3 R and 5-HT4 R in the colon of Mox 46?℃ group were decreased compared with model group(MC degranulation rates: 0.47 ± 0.56 vs 0.28 ± 0.78, P < 0.001; 5-HT: 1.42 ± 0.65 vs 7.38 ± 1.12, P < 0.001; 5-HT3R: 6.62 ± 0.77 vs 2.86 ± 0.88, P < 0.001; 5-HT4R: 4.62 ± 0.65 vs 2.22 ± 0.97, P < 0.001). CONCLUSION The analgesic effects of Mox at 46?℃ are greater than those of Mox at 43?℃, EA 1 m A and EA 3 m A.

关键词： electro-acupuncture Moxibustion Visceral hypersensitivity Analgesic effect Rats

electro-acupuncture at Conception and Governor vessels and transplantation of umbilical cord bloodderived mesenchymal stem cells for treating cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2014年第1期9卷 84-91页

作者： Haibo Yu Pengdian Chen Zhuoxin Yang Wenshu Luo Min Pi Yonggang Wu Ling Wang Affiliated Shenzhen Traditional Chinese Medicine Hospital Guangzhou University of Chinese Medicine Affiliated Shenzhen Maternity&Child Healthcare Hospital Southern Medical University

Mesenchymal stem cell transplantation is a novel means of treating cerebral ischemia/reper- fusion, and can promote angiogenesis and neurological functional recovery. acupuncture at Conception and Governor vessels also has positive effects as a treatment for cerebral ischemia/ reperfusion. Therefore, we hypothesized that electro-acupuncture at Conception and Governor vessels plus mesenchymal stem cell transplantation may have better therapeutic effects on the promotion of angiogenesis and recovery of neurological function than either treatment alone. In the present study, human umbilical cord blood-derived mesenchymal stem cells were isolated, cultured, identified and intracranially transplanted into the striatum and subcortex of rats at 24 hours following cerebral ischemia/reperfusion. Subsequently, rats were electro-acupunctured at Conception and Governor vessels at 24 hours after transplantation. Modified neurological severity scores and immunohistochemistry findings revealed that the combined interventions of electro-acupuncture and mesenchymal stem cell transplantation clearly improved neurological impairment and up-regulated vascular endothelial growth factor expression around the isch- emic focus. The combined intervention provided a better outcome than mesenchymal stem cell transplantation alone. These findings demonstrate that electro-acupuncture at Conception and Governor vessels and mesenchymal stem cell transplantation have synergetic effects on promot- ing neurological function recovery and angiogenesis in rats after cerebral ischemia/reperfusion.

关键词： nerve regeneration acupuncture human umbilical cord blood-derived mesenchymalstem cells electro-acupuncture cerebral ischemia/reperfusion vascular endothelial growth factor angiogenesis Conception vessel Governor vessel modified neurological severity score NSFC grant neural regeneration

Effect of the electro-acupuncture on senile plaques and its formation in APPD/PS1D double transgenic mice

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Genes & Diseases 2019年第3期6卷 282-289页

作者： Qinghua Yang Shujuan Zhu Jin Xu Chenglin Tang Kaihui Wu Yanjun Wu Yiying Wang Huajun Sheng Institute of Neuroscience Chongqing Medical UniversityChongqingChina College of Traditional Chinese Medicine Chongqing Medical UniversityChongqingChina

Alzheimer’s disease(AD)is a progressive neurodegenerative disease and its incidence will increase with age and is *** senile plaques(SPs)are one of three main pathological features in AD patients,which are formed by amyloid b-protein(Ab)overaccumulation.b-amyloid precursor protein(APP),b-site APP cleavage(BACE1),and insulin degrading enzyme(IDE)proteins participate in the process of Ab production and *** present,the pathogenesis of AD is not yet clear and the current treatment methods can only relief the related symptoms of *** electro-acupuncture(EA)is a traditional Chinese medicine treatment combined the acupuncture and electrical stimulation and the treatment effect can also be controlled by transform the electrical ***,in this experiment,we carried out behavioral test,immunohistochemistry(IHC),and Western Blot(WB)after different period treatments to the model mice by electro-acupuncturing“Baihui”and“Shenshu”acupoints in APPt/PS1t double transgenic *** was found that the EA therapy can improve the ability of learning,memory and spatial exploration,and reduce the deposition of SPs in brain of AD model mice,and reduce the expressions of APP and BACE1,increase the expression of IDE *** results prompt that EA can effectively alleviate the pathological process of *** speculate that EA may play a comprehensive role in preventing the development of AD,considering the previous data.

关键词： Alzheimer’s disease Amyloid b-protein electro-acupuncture Senile plaques Transgenic mice

Evaluating the Effectiveness of electro-acupuncture as A Treatment for Childhood Autism Using Single Photon Emission Computed Tomography

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Chinese Journal of Integrative Medicine 2014年第1期20卷 19-23页

作者：赵正勤贾少微胡疏孙雯 Department of Nuclear Medicine Peking University Shenzhen Hospital

Objective：To explore the effectiveness of electro-acupuncture（EA）in the treatment of childhood autism（CA）and evaluate its effectiveness using single photon emission computed tomography（SPECT）.Methods：A total of 55 CA patients（4.52±2.73 years）were enrolled in this *** patients received EA treatments and were examined by SPECT before and after ***：Following treatment,the intracerebral multiple focal radioactivity distribution defect areas of CA patients were observed to be partially ***,significant differences in the ratios of regional cerebral blood flow and global cerebral blood flow before（Fb）and after（Fe）EA treatment in different lesions were observed（in the left prefrontal cortex,t=5.01,P〈0.01;in the right prefrontal cortex,t=2.32,P〈0.05;in the left temporal lobe,t=4.54,P〈0.01;in the right temporal lobe,t=2.90,P〈0.05;in the left Broca’s area,t=5.82,P〈0.01）.After EA treatment,the patients exhibited symptomatic ***：EA is useful to treat CA and SPECT can be used to evaluate the effectiveness of this treatment.

关键词： electro-acupuncture single photon emission computed tomography childhood autism

Eficacy of electro-acupuncture in Treatment of Functional Constipation: A Randomized Controlled Trial

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Current Medical Science 2020年第2期40卷 363-371页

作者： Xiao-hu XU Ming-min ZHANG Xiao WU Sha-bei XU Wei WANG Cui hong ZHENG Guang-ying HUANG Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Tongji HospitalTongi Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Instinute of Integrated Tradional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Functional constipation(FC)is a chronic discasc that significantly afcts the life quality of *** has been used for the treatment of FC for many years,but its effectiveness has not been scientifcally *** present study aimed to evaluate the efficacy of electro-acupuncture(EA)in relieving the symptoms,mental states and quality of life(QOL)of FC patients.A total of 96 FC patients were randomly allocated into EA,mosapride&sham EA group(MS)and mosapride control group(MC).In the EA group,patients were treated with 16 sessions of needling at Quchi(LI1I)and Shangjuxu(ST37)bilaterally,5 times a week in the first 2 weeks,and 3 times *** in the last 2 *** the MC group,patients were treated with 5 mg mosapride citrate three times a day for 4 *** the MS group,patients underwent sham EA and the same mosapride citrate treatment as in the MC *** primary outcome was the number of weekly spontaneous bowel movements(SBMs).The secondary outcomes included stool consistency,intensity of defecating difficulty,36-Item Short-Form Health Survey(SF-36),Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS),and the validated Patient Assessment of Constipation-Quality of Life(PAC-QOL).The results showed that as compared with the baseline,EA significantly improved the weekly SBMs,stool consistency and intensity of defecating difficulty(P<0.05).It also partly ameliorated the PAC-QOL,SF-36,SDS and SAS scores when compared with MC or MS group(P<0.05).However,no significant difference was observed between MS and MC groups in bowel function outcomes and QOL *** was concluded that EA could effectivcly improve bowel function,mental states and QOL of FC patients.

关键词： electro-acupuncture functional constipation sham electro-acupuncture mosapride citrate Patient Assessment of Constipation-Quality of Life(PAC-QOL)

Efficacy and Duration of electro-acupuncture Combined with Conventional Antipsychotics for Schizophrenia:A Meta-Analysis

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World Journal of Traditional Chinese Medicine 2023年第2期9卷 212-223页

作者： Zhao-Han Huang Yuan Fang Qi Yu Tong Wang College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Shanghai Center for Women and Children's Health ShanghaiChina

Introduction:This study aimed to evaluate the effectiveness and optimal course time of electro-acupuncture(EA)combined with conventional antipsychotics in the treatment of schizophrenia(SZ)and to provide a basis for its clinical ***:Relevant databases and authoritative websites were retrieved,and references were screened up to May *** quality evaluation and data extraction were carried out according to the requirements of Cochrane version 5.1.0,and meta-analysis was conducted using Rav Man5.4 ***:In total,16 randomized controlled trails comprising 1352 patients were ***-analysis revealed that the observation group showed greater improvements than the control group in total clinical efficacy(P0.05).In the 4-6 weeks following treatment,a significant improvement in all the four components of the PANSS scores was observed in the observation ***:The efficacy of EA combined with conventional antipsychotics for SZ is better than that of psychiatric drugs *** addition,the effect of a 4-to 6-week treatment course on each outcome index is more significant,and the efficacy is higher.

关键词： electro-acupuncture meta-analysis schizophrenia

Combination therapy of scalp electro-acupuncture and medication for the treatment of Parkinson's disease: A systematic review and meta-analysis

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Journal of Traditional Chinese Medical Sciences 2019年第1期6卷 26-34页

作者： Tianyao Qiang Cong Gai Yuan Chai Wandi Feng Haojie Ma Yi Zhang Jing Feng Zhenyu Guo Ling Ma Hongmei Sun School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Universitélibre de Bruxelles Brussels 1050Belgium

Objective:To summarize the current clinical evidence related to the therapeutic effects and safety of adjuvant scalp electro-acupuncture (SEA) treatment for Parkinson's disease in ***:Following the PRISMA statement,seven electronic databases were searched to retrieve randomized controlled clinical trials that used SEA combined with medication as the treatment intervention,and medication as the *** 5.3 was used to analyze outcomes,including the Unified Parkinson's Disease Rating Scale (UPDRS),Webster scale,effectiveness rate,and UPDRS ***:Nine randomized controlled trials,with certain methodological flaws and risks of bias,were included that involved 474 *** combined with medication was more effective than medication alone in overall therapeutic effects,as evidenced by total UPDRS scores (mean difference (MD):7.15,95% confidence interval [CI] 0.24 to 14.07,P =.04),Webster scores (MD:1.60,95% CI 0.20 to 2.99,P =.03),and effectiveness rate (risk ratio:1.35,95% CI 1.19 to 1.54,P <.001).In addition,there was significant improvement in pooled motor function results after adjuvant SEA treatment compared with medication alone (MD:5.75,95% Cl 4.18 to 7.32,P <.001).Conclusion:The combination of SEA and medication may be a promising intervention for patients with Parkinson's disease,especially to improve motor ***,results were inconclusive,and additional studies with rigorous experimental design and larger sample sizes are needed to verify these results.

关键词： Parkinson's disease Scalp electro-acupuncture Unified Parkinson's Disease Rating Scale Motor function

Progress of Animal Research on electro-acupuncture Treatment for Depression

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Chinese Medical Sciences Journal 2014年第1期29卷 43-47页

作者： Yu-ping Mo Hai-jiang Yao Hong-tao Song An-ping Xu Yin-shan Tang Zhi-gang Li School of acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine

This paper summarized the Chinese literatures in the previous 5 years about the pre-clinical animal researches on the application of electro-acupuncture(EA) treatment for depression,searched in China National Knowledge Infrastructure(CNKI).The efficiency of EA treatment for depression and the mechanism of it were discussed,to shed light on new ideas and new fronts for the further research on depression in clinical or pre-clinical fields.

关键词： electro-acupuncture depression animal research review

Effect of electro-acupuncture on S-100 Protein Expression of Nerve Fibers in the Repair Process of Transected Sciatic Nerve in Rats

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Journal of acupuncture and Tuina Science 2007年第1期5卷 10-13页

作者：李庆雯朱忠春(Translator) Tianjin Institute of Physical Education Tianjin 300193 P.R. China 不详

Objective： To observe the effects of electro-acupuncture on S-100 protein expression of nerve fibers on the regeneration process of transected sciatic nerve of rats, so as to explore the partial mechanism of electro-acupuncture treatment for peripheral nerve injury. Methods： Following rat＇s sciatic nerve transection, the nerve regeneration chamber model was established, then the rat was given electro-acupuncture stimulation at the frequency of 5 Hz and frequency of 100 Hz, and the immunohistochemical staining method and image analyzing semi-quantitative technique were adopted to determine the percentage of S-100 protein area, hence to observethe effect of electro-acupuncture on the repair process of transected sciatic nerve of rat and the S-100 protein expression. Results： electro-acupuncture could significantly potentiate the S-100 protein expression of Schwann Cells （SC） in the repair process of transected sciatic nerve. At the 14th week, 17th week and 20th week after operation, the percentages of S-100 protein area were more obviously increased in 5 Hz electro-acupuncture group and 100 Hz electro-acupuncture group than in model group, with significant differences （P〈0.05）. Especially, the better effect was obtained in 5 Hz electro-acupuncture group. Judging from the dynamic treatment, it is very vital to be treated early. Conclusion： electro-acupuncture is an effective method for the treatment of peripheral nerve injury, and its therapeutic effect is related to the improvement of SC proliferation.

关键词： electro-acupuncture Nerve Fibers/Injuries S- 100 protein