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INDUCTION OF ectodermal CELLS FROM VEGETALENDODERMAL BLASTOMERES OF AMPHIOXUS(BRANCHIOSTOMA BELCHERI TSINGTAUNESE) EMBRYOS BY THE CALCIUM IONOPHORE A23187

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Chinese Journal of Oceanology and Limnology 1999年第2期17卷 97-104页

作者：张士璀郑家声张红卫毛炳宇 College of Marine Life Sciences Ocean University of Qingdao Qingdao China Department of Biology Shandong University Jinan China

Timing of vegetal-endodermal cell determination in amphioxus embryos remains uncertain. We tentatively testal effects of A23187, the calcium ionophore, on the deveopment of vegetal blastomeres isolated at the 16-cell stage. It was found that when vegetal blastomres committed to endodermwere treated with A23187 prior to gastrulation, they were transformed into ectodermal cells as evidenced by the cell morphology and function characteristic of epidermis. Howver, the developmental fate of the sam blastomeres untreated or treated with DMSO at the same stage or of those treated with A23187 after gastrulation remained unchanged. Thus, vegetal-endodermal cells in amphioxus embryos are not irreversibly deermined before the gastrula stage, and artificial incarease in intracelluar Ca2+ concentration can induce transdetermination of the predetermined endodermal cells into ectodermal cells.

关键词： amphioxus ectodermal cells vegetal blastomeres ionophore induction

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A mathematical Model for Inter-Cellular Inductive

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Computational Molecular Bioscience 2012年第3期2卷 102-107页

作者： Jeyaraman Srividhya The Biocomplexity Institute Indiana University Bloomington IN

In vertebrate limb, a group of specialized epithelial cells called Apical ectodermal Ridge (AER) form at the boundary of dorsal and ventral limb ectoderm. Recent experiments suggest that AER forms at the boundary of Fringe expressing and Fringe non-expressing cells by a specific type of receptor-ligand interaction called as inductive signaling, involving the transmembrane proteins Notch, Serrate and Delta. Experiments conducted on Drosophila wing disc have shown that Fringe inhibits the binding ability of Serrate ligand to Notch and enhances that of Delta to Notch. Although several of the signaling elements have been identified experimentally, it remains unclear how the inter-cellular interactions can give rise to such a boundary of specialized cells. Here we present an ordinary differential equation (ODE) model involving Delta→Notch and Serrate→Notch interactions between juxtaposed Fringe expressing and Fringe nonexpressing cells. When simulated in a compartmentalized set up, this model gives rise to high Notch levels at the boundary of Fringe expressing and Fringe non-expressing cells.

关键词： Delta-Notch Signaling Apical ectodermal Ridge Compucell3D Boundary Formation Inductive Signaling

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Midline Spinal Cord Hamartomas—A Report of Six Cases

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International Journal of Clinical Medicine 2013年第6期4卷 291-295页

作者： Damera Naveen Chandra Rao Vallabhaneni Kalyan Chakravarthy Eslavath Aruna Gundala Venkata Ratnam Diddi Ranga Rao Department of Pathology Pinnamaneni Siddhartha Institute of Medical Sciences & Research Foundation Chinna Avutapalli India Department of Pathology Pinnamaneni Siddhartha Institute of Medical Sciences & Research Foundation Chinna Avutapalli India.

Midline Spinal Cord Hamartomas are relatively rare and asymptomatic. These lesions may present with a tethered cord and a normal overlying skin, a skin dimple, a dermal sinus tract or dense collagen. Most patients have few or no neurological symptoms related to them. Microscopically they are composed of mature and well-differentiated ectodermal and mesodermal elements, meningothelial cells, calcification, and even urothelium. We report MRI and histologic features of midline spinal cord hamartomas in six cases.

关键词： Hamartoma Meningothelial Cells ectodermal

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