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Distinct neuronal excitability alterations of medial prefrontal cortex in early-life neglect model of rats

Animal models and Experimental Medicine 2022年第3期5卷 274-280页

作者： Yu Zhang Xiuping Sun Changsong Dou Xianglei Li Ling Zhang Chuan Qin NHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)Comparative Medicine CenterPeking Union Medical College(PUMC)BeijingChina National Human Diseases Animal model Resource Center BeijingChina Beijing Engineering Research Center for Experimental Animal models of Human Critical Diseases BeijingChina International Center for Technology and Innovation of animal model BeijingChina Changping National laboratory(CPNL) BeijingChina

Object:early-life neglect has irreversible emotional effects on the central nervous *** this work,we aimed to elucidate distinct functional neural changes in me-dial prefrontal cortex(mPFC)of model ***:Maternal separation with early weaning was used as a rat model of early-life *** excitation of glutamatergic and GABAergic neurons in rat mPFC was recorded and analyzed by whole-cell patch ***:Glutamatergic and GABAergic neurons of mPFC were distinguished by typi-cal electrophysiological *** excitation of mPFC glutamatergic neurons was significantly increased in male groups,while the excitation of mPFC GABAergic neurons was significant in both female and male groups,but mainly in terms of rest membrane potential and amplitude,***:Glutamatergic and GABAergic neurons in medial prefrontal cortex showed different excitability changes in a rat model of early-life neglect,which can contribute to distinct mechanisms for emotional and cognitive manifestations.

关键词： early-life neglect model GABAergic glutamatergic maternal separation with early weaning medial prefrontal cortex neuronal excitability

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