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Ultra-small superparamagnetic iron oxide nanoparticles for intra-articular targeting of cartilage in early osteoarthritis

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Regenerative Biomaterials 2023年第1期10卷 1111-1121页

作者： Jun Wu Changqiang Wu Zhongyuan Cai Haojie Gu Li Liu Chunchao Xia Su Lui Qiyong Gong Bin Song Hua Ai Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu 610207China Medical Imaging Key Laboratory of Sichuan Province School of Medical ImagingNorth Sichuan Medical CollegeNanchong 637000China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China Department of Radiology Huaxi MR Research Center(HMRRC)Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province Key Laboratory of Transplant Engineering and ImmunologyNHCResearch Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610064China Department of Radiology West China Xiamen Hospital of Sichuan UniversityFujianXiamen 361000China Department of Radiology Sanya People’s HospitalHainanSanya 572000China

early diagnosis of osteoarthritis(OA)is critical for effective cartilage ***,lack of blood vessels in articular cartilage poses a barrier to contrast agent delivery and subsequent diagnostic *** address this challenge,we proposed to develop ultra-small superparamagnetic iron oxide nanoparticles(SPIONs,4 nm)that can penetrate into the matrix of articular cartilage,and further modified with the peptide ligand WYRGRL(particle size,5.9 nm),which allows SPIONs to bind to type II collagen in the cartilage matrix and increase the retention of *** II collagen in the cartilage matrix is gradually lost with the progression of OA,consequently,the binding of peptide-modified ultra-small SPIONs to type II collagen in the OA cartilage matrix is less,thus presenting different magnetic resonance(MR)signals in OA group from the normal *** introducing the AND logical operation,damaged cartilage can be differentiated from the surrounding normal tissue on T1 and T2 AND logical map of MR images,and this was also verified in histology ***,this work provides an effective strategy for delivering nanosized imaging agents to articular cartilage,which could potentially be used to diagnosis joint-related diseases such as osteoarthritis.

关键词： early osteoarthritis magnetic resonance imaging superparamagnetic iron oxide collagen type II targeting peptide

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Hallux rigidus treated with adipose-derived mesenchymal stem cells:A case report

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World Journal of Orthopedics 2021年第1期12卷 51-55页

作者： Adriano Braile Giuseppe Toro Annalisa De Cicco Antonio Benedetto Cecere Fabio Zanchini Alfredo Schiavone Panni Department of Medical and Surgical Specialties and Dentistry University of Campania“Luigi Vanvitelli”Naples 80138Italy

BACKGROUND First metatarsophalangeal joint arthritis(FMTPA),also known as hallux rigidus,is the most frequent degenerative disease of the *** is made through both clinical and radiological *** medicine showed promising results in the treatment of early *** aim of the present study was to report the results of a case of FMTPA treated with the injection of autologous adipose-derived mesenchymal stem *** SUMMARY A gentleman of 50 years of age presented with a painful hallux rigidus grade 2 resistant to any previous conservative treatment(including nonsteroidal antiinflammatory drugs and hyaluronic acid injections).An injection of autologous adipose-derived mesenchymal stem cells into the first metatarsophalangeal joint was *** adverse events were reported,and both function and pain scales improved after 9 mo of *** The FMTP joint injection of mesenchymal stem cells improved symptoms and function in our patient with FMTPA at 9 mo of follow-up.

关键词： First metatarsophalangeal joint arthritis Hallux rigidus Stem cells Regenerative medicine early osteoarthritis Adipose derived-mesenchymal stem cells Case report

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