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Recent advances in living cell nucleic acid probes based on nanomaterials for early cancer diagnosis

Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 22-40页

作者： Xuyao Liu Qi Shi Peng Qi Ziming Wang Tongyue Zhang Sijia Zhang Jiayan Wu Zhaopei Guo Jie Chen Qiang Zhang Department of Thyroid Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The early diagnosis of cancer is vital for effective treatment and improved prognosis. Tumor biomarkers, which can be used for the early diagnosis, treatment, and prognostic evaluation of cancer, have emerged as a topic of intense research interest in recent years. Nucleic acid, as a type of tumor biomarker, contains vital genetic information, which is of great significance for the occurrence and development of cancer. Currently, living cell nucleic acid probes, which enable the in situ imaging and dynamic monitoring of nucleic acids, have become a rapidly developing field. This review focuses on living cell nucleic acid probes that can be used for the early diagnosis of tumors. We describe the fundamental design of the probe in terms of three units and focus on the roles of different nanomaterials in probe delivery.

关键词： Nucleic acid Nanomaterials In situ detection Living cell early cancer diagnosis

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An Approach to the Simultaneous Detection of Multiple Biomarkers for the early diagnosis of Liver cancer Using Quantum Dot Nanoprobes

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Infectious Microbes & Diseases 2022年第1期4卷 34-40页

作者： Ningtao Cheng Jing Fu State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery HospitalShanghaiChina National Center for Liver cancer ShanghaiChina

Biomarker-based early diagnosis of liver cancer is of high clinical value for reducing the mortality ***,it has been challenging to establish early detection methods with a single biomarker such as alpha-fetoprotein(AFP)because of limited diagnostic sensitivity and ***,developing multiplexed biomarker detection assays is crucially important for early ***,simultaneous detection methods involving three or more biomarkers have been *** we suggest employing the serological biomarker panel of glypican-3(GPC3),dickkopf-1(DKK1),and AFP for liver cancer *** present a rapid simultaneous detection approach for the biomarker panel labeled with three fluorescent quantum dot nanoprobes(emission wavelengths at 565 nm,605 nm,and 655 nm).As a proof-of-concept,simultaneous fluorescence detection of the biomarker panel was demonstrated using mixed reference samples containing human recombinant GPC3,DKK1,and AFP *** simultaneous detection approach conferred a linear range of 0.625–2.5 ng·mL^(-1)for the entire biomarker panel,which merits further clinical validation for the simultaneous and accurate determination of the biomarker panel in human serum samples.

关键词： nanomedical detection early cancer diagnosis liver cancer multiplex fluoroassay of biomarkers quantum dots simultaneous biomarker detection

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