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Microarray profiles on age-related genes in the earlier postnatal rat visual cortex

Chinese Medical Journal 2011年第10期124卷 1545-1550页

作者： YANG Liu NIE Yu-hong ZHOU Li-hua LIN Shao-chun WU Kai-li Department of Ophthalmology Beijing Tiantan Hospital Capital Medical University Beijingt00050 China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou Guangdong 510060 China Department of Anatomy Zhongshan Medical College Sun Yat-sen University Guangzhou Guangdong 510060 China Department of Ophthalmology Renmin Hospital of Wuhan University Wuhan Hubei 430060 China

Background Accumulating evidence indicates that both innate and adaptive mechanisms are responsible for the postnatal development of the mammalian visual cortex. Most of the studies, including gene expression analysis, were performed on the visual cortex during the critical period; few efforts were made to elucidate the molecular changes in the visual cortex during much earlier postnatal stages. The current study aimed to gain a general insight into the molecular mechanisms in the developmental process of the rat visual cortex using microarray to display the gene expression profiles of the visual cortex on postnatal *** All age-matched Sprague-Dawley rats in various groups including postnatal day 0 （PO, n=20）, day 10 （P10,n=15）, day 20 （P20, n=15） and day 45 （P45, n=10） were sacrificed respectively. Fresh visual cortex from the binocular area （Area 17） was dissected for extraction of total RNA for microarray analyses. Taking advantage of annotation information from the gene ontology and pathway database, the gene expression profiles were systematically and globally *** Of the 31 042 gene sequences represented on the rat expression microarray, more than 4000 of the transcripts significantly altered at days 45,20 or 10 compared to day 0. The most obvious alteration of gene expression occurred in the first ten days of the postnatal period and the genomic activities of the visual cortex maintained a high level from birth to day 45. Compared to the gene expression at birth, there were 2630 changed transcripts that shared in three postnatal *** up-regulated genes in most signaling pathways were more than those of the down-regulated *** Analyzing gene expression patterns, we provide a detailed insight into the molecular organization of the developing visual cortex in the earlier postnatal rat. The most obvious alteration of gene expression in visual cortex occurred in the first ten days. Our data were a basis to identify new rele

关键词： microarray analysis earlier postnatal development visual cortex rat

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