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Traumatic brain injury induced by exposure to blast overpressure via ear canal

Neural Regeneration Research 2022年第1期17卷 115-121页

作者： Yang Ou Brad AClifton Jinghui Li David Sandlin Na Li Li Wu Chunming Zhang Tianwen Chen Jun Huang Yue Yu Jerome Allison Fan Fan Richard JRoman James Shaffery Wu Zhou Yi Pang Hong Zhu Departmant of Otolaryngology and Head Neck Surgery Department of Neurobiology and Anatomical Sciences MD Program School of Medicine Graduate Program in Neuroscience Department of Pediatrics Department of Pharmacology and Toxicology Department of Psychiatry and Human Behavior University of Mississippi Medical CenterJacksonMSUSA Kunming Medical University KunmingYunnan ProvinceChina Department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina

Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian populations.Unprotected ears are most often damaged following exposure to blasts.Although there is an association between tympanic membrane perforation and TBI in blast exposure victims,little is known about how and to what extent blast energy is transmitted to the central nervous system via the external ear canal.The present study investigated whether exposure to blasts directed through the ear canal causes brain injury in LongEvans rats.Animals were exposed to a single blast(0–30 pounds per square inch(psi))through the ear canal,and brain injury was evaluated by histological and behavioral outcomes at multiple time-points.Blast exposure not only caused tympanic membrane perforation but also produced substantial neuropathological changes in the brain,including increased expression of c-Fos,induction of a profound chronic neuroinflammatory response,and apoptosis of neurons.The blast-induced injury was not limited only to the brainstem most proximal to the source of the blast,but also affected the forebrain including the hippocampus,amygdala and the habenula,which are all involved in cognitive functions.Indeed,the animals exhibited long-term neurological deficits,including signs of anxiety in open field tests 2 months following blast exposure,and impaired learning and memory in an 8-arm maze 12 months following blast exposure.These results suggest that the unprotected ear canal provides a locus for blast waves to cause TBI.This study was approved by the Institutional Animal Care and Use Committee at the University of Mississippi Medical Center(Animal protocol#0932 E,approval date:September 30,2016 and 0932 F,approval date:September 27,2019).

关键词： anxiety blast ear ear protection learning memory microglia neuroinflammation neuron rat traumatic brain injury

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ear Field Adaptive Noise Control for Snoring:An Real-time Experimental Approach

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 158-166页

作者： Lichuan Liu Karunakar Reddy Pottim Sen M.Kuo IEEE the Electrical Engineering Department Northern Illinois University the Department of Electrical Engineering Chung Yuan Christian University

In this paper, an active noise control(ANC) system is developed to provide an effective and non-intrusive solution for reducing loud snoring to provide a quiet environment for a snorer's bed partner. An adaptive least mean square(LMS)algorithm optimized for different kinds of snore signals is introduced and theoretically analyzed. Also, a residual noise masking approach is proposed to further reduce the effect of the snore noise without interfering with the LMS algorithm. Computer simulations followed by real-time experiments are conducted to demonstrate the feasibility of the snore ANC systems based on a pillow setup. For the optimum effect based on the characteristics of human hearing, the performance of the proposed approach is evaluated by using the multi-channel feedforward ANC systems based on the filtered-X least mean square(FXLMS) algorithm.Compared with a traditional headboard setup for snoring noise control, the proposed snore ANC systems optimized for ear field operation yield much higher noise reduction around the ears of the snorer's bed partner.

关键词： Active noise control (ANC) audio integrated ANC ear field filtered-X least mean square (FXLMS) snore multi-channel

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ear

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小学生时代（大嘴英语） 2024年第5期 22-23页

ear(耳朵)已经是我们的老朋友了,但它其实有好多副面孔。你都了解吗?

关键词： ear 耳朵 ear

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永仁心左心室辅助装置新型双缝边无尖端入血管植入技术应用

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中华胸心血管外科杂志 2024年第1期40卷 17-19页

作者：于涛方明王文艳左明良李映雪谢揆择黄克力四川省医学科学院四川省人民医院电子科技大学附属医院心脏外科中心成都610072 重庆永仁心医疗器械有限公司重庆400700 四川省医学科学院四川省人民医院电子科技大学附属医院心衰中心成都610072 四川省医学科学院四川省人民医院电子科技大学附属医院心血管超声及心功能科成都610072 成都中医药大学医学与生命科学学院成都610075

结合永仁心(EVAHearT)植入式左心室辅助装置新一代双缝边无尖端(double cuff tip-less,DCT)入血管的结构特点,阐述其在临床中的设计优势:手术容错性高且不易损伤心内膜。重点介绍DCT入血管的术前评估、具体手术步骤及技术细节,结合常见... 详细信息

结合永仁心(EVAHearT)植入式左心室辅助装置新一代双缝边无尖端(double cuff tip-less,DCT)入血管的结构特点,阐述其在临床中的设计优势:手术容错性高且不易损伤心内膜。重点介绍DCT入血管的术前评估、具体手术步骤及技术细节,结合常见临床最佳手术方法与错误手法进行对比。

关键词：植入式技术细节双缝容错性 DCT 永仁 ear 术前评估

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A rare case of salivary gland choristoma in the middle ear with pharyngeal hamartoma

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Chinese Medical Journal 2019年第8期132卷 1000-1002页

作者： Qiu-Yu Su Shao-Juan Hao Le Wang Fang-Lei Ye Department of Otorhinolaryngology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China

To the Editor:Salivary gland choristoma of the middle ear is a normal salivary gland tissue located in the middle ear.It is a benign and slow growing neoplasm that usually involves the ossicular chain and facial nerve,[1,2]and most of the patients usually suffer from conductive hearing loss without tympanic membrane(TM)perforation.The histological feature consisted of normal salivary gland tissue with a mass covered by ciliated columnar epithelium.To the best of our knowledge,it was first described by Buckmiller et al.[3]We presented a rare case of salivary gland choristoma in which the patient had a history of hamartoma in the pharynx and the mass was covered by squamous epithelium.

关键词： salivary gland choristoma middle ear pharyngeal hamartoma

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Tophaceous gout of the middle ear

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Journal of Otology 2019年第4期14卷 155-157页

作者： Stephane Gargula Guillaume Poillon Mary Daval Marc Williams Mathieu Veyrat Homa Adle-Biassette Denis Ayache Department of Otolaryngogy Head and Neck SurgeryFoundation Adolphe de Rothschild HospitalParisFrance Department of Neuroradiology Foundation Adolphe de Rothschild HospitalParisFrance Department of Pathology Lariboisiere HospitalParis DiderotParis-Cite-Sorbonne UniversityParisFrance

We present a very rare case of tophaceous gout of the middle ear causing conductive hearing loss,with special emphasis on Computed Tomography presentation.

关键词： Gout Middle ear Hearing loss Conductive hearing loss Computed tomography

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Wheat ear carbon assimilation and nitrogen remobilization contribute significantly to grain yield

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Journal of Integrative Plant Biology 2016年第11期58卷 914-926页

作者： Bangwei Zhou Maria Dolores Serret Abdelhalim Elazab Jordi Bort Pie José Luis Araus Iker Aranjuelo álvaro Sanz-Sáez Key Laboratory of Vegetation Ecology Ministry of EducationInstitute of Grassland ScienceNortheast Normal University Unit of Plant Physiology Faculty of BiologyUniversity of Barcelona Agrobiotechnology Institute Public University of Navarra-CSIC-Navarra GovernmentArrosadia Campus Department of Plant Biology University of the Basque Country Pharmacy Faculty

The role of wheat ears as a source of nitrogen （N） and carbon （C） in the grain filling process has barely been studied. To resolve this question, five wheat genotypes were labeled with 15N-enriched nutrient solution. N remobilization and absorption were estimated via the nitrogen isotope composition of total organic matter and Rubisco. Gas exchange analyses showed that ear photosynthesis contributed substantially to grain filling in spite of the great loss of C due to respiration. Of the total kernel N, 64.7% was derived from the N acquired between sowing and anthesis, while the remaining 35.3% was derived from the N acquired between anthesis and maturity. In addition, 1.87 times more N was remobilized to the developing kernel from the ear than from the flag leaf. The higher yielding genotypes showed an increased N remobflization to the kernel compared to the lower yielding genotypes. In addition, the higher yielding genotypes remobilized more N from the ears to the kernel than the lower yielding genotypes, while the lower yielding genotypes remobilized more N from the flag leaf to the kernel. Therefore, the ears contribute significantly toward fulfilling C and N demands during grain filling.

关键词： Carbon accumulation ear grain yield nitrogenaccumulation Rubisco

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Changes of moisture distribution and migration in fresh ear corn during storage

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Journal of Integrative Agriculture 2019年第11期18卷 2644-2651页

作者： WANG Hao LIU Jing-sheng MIN Wei-hong ZHENG Ming-zhu LI Hao College of Food Science and Engineering/The National Engineering Laboratory on Wheat and Corn Further Processing Jilin Agricultural University

Understanding of moisture changes in fresh ear corn(Zea mays L.)during storage is imperative for maintaining fresh corn quality.The changes of moisture distribution and migration in fresh ear corn during storage were investigated using low-field nuclear magnetic resonance(NMR)and magnetic resonance imaging(MRI).Water loss was greater than water migration in fresh ear corn within the first hour of storage;thereafter,water loss was weaker than water migration.With the extension of storage time,the signal intensity of MRI in different parts of sliced fresh corn with cob showed a downward trend,and the rate of signal intensity reduction was higher in the peripheral area than at the central part of sliced fresh corn with cob.The relative proportion of bound water increased with a concomitant drop in that of free water,when the total water content reduced in fresh ear corn under storage.In conclusion,NMR and MRI are useful and non-destructive tools for real-time monitoring of moisture distribution,migration,and loss in fresh ear corn during storage to assess its quality.These results can be used for future design of the preserving and processing conditions for fresh ear corn.

关键词： fresh ear corn NMR MRI moisture distribution moisture migration

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Longitudinally profiled plate leveling theory based on linear decreasing leveling scheme

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Journal of Iron and Steel Research(International) 2019年第2期26卷 130-136页

作者： Jian-liang Sun Xing-ming Du Kai Li Yan Peng National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004HebeiChina State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004HebeiChina

An an alytical model based on linear decreasi ng leveli ng scheme was proposed to inv estigate the longitu din ally profiled plate leveling process.Considering the variable cross-sectional thickness of longitudinally profiled plate and the dynamic reductions in leveling rolls,the reduction models of upper and lower rolls,the leveling force model and the leveling moment model were established,respectively,based on linear decreasing leveling scheme.Moreover,the finite element model of longitudinally profiled plate leveling process was established based on ABAQUS.Then,the total displacements of upper and lower rolls,the leveling force and the stress distribution of longifudinally profiled plate in the leveling process were calculated.To verify the validity of the proposed models,calculated leveling forces were compared with the measured values,and very good agreements are found.Calculated results show that linear decreasing leveling scheme is suitable for leveling longitudinally profiled plate.

关键词： Longitudi nally profiled plate Lin ear decreasing leveling Dynamic reduction Residual stress

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A child with severe inner ear malformations with favorable hearing utilization and balance functions after wearing hearing aids

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Journal of Otology 2017年第1期12卷 41-46页

作者： Yusuke Kimura Takeshi Masuda Akifumi Tomizawa Hideaki Sakata Kimitaka Kaga National Institute of Sensory Organs National Tokyo Medical Center Tokyo Japan Department of OtolaryngologyeHead and Neck Surgery Nihon University School of Medicine Tokyo Japan Department of Speech Language and Hearing Therapy Mejiro University Saitama Japan Kawagoe Otology Institute Saitama Japan

Infants with congenital deafness caused by severe bilateral inner ear malformations frequently suffer from severe hearing loss and poor balance. Unfortunately, the use of hearing aids is usually ineffective in recovering hearing, necessitating cochlear implants. We report a case of a 6-year-old boy with congenital deafness and bilateral inner ear malformations(right side, incomplete partition type I [IP-I]; left side, common cavity deformity). Hearing aids had a remarkable effect in this patient, enabling sufficient and favorable hearing recovery such as to allow the patient to engage in daily conversations. Per-rotatory nystagmus was recorded on an electronystagmogram for both right and left rotations in a damped rotational chair test. It is rare for deaf children with severe bilateral inner ear malformation to demonstrate favorable development in hearing and good equilibrium function. Our findings suggest that auditoryevestibular hair cells in this patient may have been partially preserved despite IP-I in the right ear and common cavity deformity of the left ear.

关键词： Congenital hearing loss Inner ear malformations Rotation chair test

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